STKL1_MOUSE
ID STKL1_MOUSE Reviewed; 662 AA.
AC Q80YS9; A2ALB0;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 3.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Serine/threonine kinase-like domain-containing protein STKLD1;
DE AltName: Full=Serine/threonine kinase-like domain-containing protein 1;
DE AltName: Full=Sugen kinase 071;
GN Name=Stkld1; Synonyms=Gm711, Sgk071;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC inactive.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC kinase family. STKL subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.
CC -!- CAUTION: Asn-126 is present instead of the conserved Asp which is
CC expected to be an active site residue. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BC050806; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AL773563; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC050806; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS15818.1; -.
DR RefSeq; NP_941030.2; NM_198628.2.
DR RefSeq; XP_006498176.2; XM_006498113.3.
DR AlphaFoldDB; Q80YS9; -.
DR SMR; Q80YS9; -.
DR STRING; 10090.ENSMUSP00000062967; -.
DR PhosphoSitePlus; Q80YS9; -.
DR PaxDb; Q80YS9; -.
DR PRIDE; Q80YS9; -.
DR ProteomicsDB; 257494; -.
DR Antibodypedia; 31860; 212 antibodies from 23 providers.
DR DNASU; 279029; -.
DR Ensembl; ENSMUST00000055406; ENSMUSP00000062967; ENSMUSG00000049897.
DR GeneID; 279029; -.
DR KEGG; mmu:279029; -.
DR UCSC; uc008iwm.1; mouse.
DR CTD; 169436; -.
DR MGI; MGI:2685557; Stkld1.
DR VEuPathDB; HostDB:ENSMUSG00000049897; -.
DR eggNOG; KOG0658; Eukaryota.
DR GeneTree; ENSGT00390000018038; -.
DR HOGENOM; CLU_013402_0_0_1; -.
DR InParanoid; Q80YS9; -.
DR OMA; ILDMTSC; -.
DR OrthoDB; 268303at2759; -.
DR PhylomeDB; Q80YS9; -.
DR TreeFam; TF336364; -.
DR BioGRID-ORCS; 279029; 2 hits in 67 CRISPR screens.
DR ChiTaRS; Stkld1; mouse.
DR PRO; PR:Q80YS9; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q80YS9; protein.
DR Bgee; ENSMUSG00000049897; Expressed in spermatocyte and 32 other tissues.
DR ExpressionAtlas; Q80YS9; baseline and differential.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR Pfam; PF00069; Pkinase; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..662
FT /note="Serine/threonine kinase-like domain-containing
FT protein STKLD1"
FT /id="PRO_0000307899"
FT DOMAIN 1..202
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 639..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 2..10
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 25
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ SEQUENCE 662 AA; 74843 MW; B5D6768182C337FF CRC64;
MLNPGALGVN LVVEELETET KFLIKQVECI DEHHANKALE ELMPLLKLQH PNLSLYHEMF
IMWNNEISSL FLCLVMDYYS QGTFQNIMEN KRKLKAVVDT EWMHTMLSQV LDAIEYLHKL
NIVHRNLKPS NIVLVNSGYC KLQDMSSQAL MTHEAKWNVR AEEDPCQKSW MAPEALKFSF
STKSDIWSLG CIILDMATCS FLNDTEAMQL RKAIRHHPGS LKPILKTMEE KQIPGTDVYY
LLLPFMLHIN PSDRLAIKDV MQVTFMSNSF KSSSVALNMQ RQKVPIFITD VLLEGNMANI
LDVMQNFSSR PEVQLRAINK LLTMPEDQLG LPWPTELLEE VISIIKQHGR ILDILLSTCS
LLLRVLGQAL AKDPEAEIPR SSLIISFLMD TLRSHPNSER LVNVVYNVLA IISSQGQISE
ELEEEGLFQL AQENLEHFQE DRDICLSILS LLWSLLVDVV TVDKEPLEQL SGMVTWVLAT
HPEDVEIAEA GCAVLWLLSL LGCIKESQFE QVVVLLLRSI QLCPGRVLLV NNAFRGLASL
AKVSELVAFR IVVLEEGSSG LHLIQDIYKL YKDDPEVVEN LCMLLAHLTS YKEILPEMES
GGIKDLVQVI RGRFTSSLEL ISYADEILQV LEANAQPGLQ EDQLEPPAGQ EAPLQGEPLF
RP
