STKLH_ARATH
ID STKLH_ARATH Reviewed; 386 AA.
AC Q8VYD2; Q9SL98;
DT 07-SEP-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=GLABROUS1 enhancer-binding protein-like 1 {ECO:0000303|PubMed:18162594};
DE AltName: Full=Protein GPL1 {ECO:0000303|PubMed:18162594};
DE AltName: Full=Storekeeper-like protein At2g25650 {ECO:0000305};
GN Name=GPL1 {ECO:0000303|PubMed:18162594};
GN OrderedLocusNames=At2g25650 {ECO:0000312|Araport:AT2G25650};
GN ORFNames=F3N11.10 {ECO:0000312|EMBL:AAD31366.2};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=12535344; DOI=10.1046/j.1365-313x.2003.01622.x;
RA Curaba J., Herzog M., Vachon G.;
RT "GeBP, the first member of a new gene family in Arabidopsis, encodes a
RT nuclear protein with DNA-binding activity and is regulated by KNAT1.";
RL Plant J. 33:305-317(2003).
RN [6]
RP INTERACTION WITH GEBP; GPL2 AND GPL3, SUBUNIT, SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RX PubMed=18162594; DOI=10.1104/pp.107.110270;
RA Chevalier F., Perazza D., Laporte F., Le Henanff G., Hornitschek P.,
RA Bonneville J.M., Herzog M., Vachon G.;
RT "GeBP and GeBP-like proteins are noncanonical leucine-zipper transcription
RT factors that regulate cytokinin response in Arabidopsis.";
RL Plant Physiol. 146:1142-1154(2008).
RN [7]
RP FUNCTION.
RX PubMed=21875893; DOI=10.1104/pp.111.179804;
RA Perazza D., Laporte F., Balague C., Chevalier F., Remo S., Bourge M.,
RA Larkin J., Herzog M., Vachon G.;
RT "GeBP/GPL transcription factors regulate a subset of CPR5-dependent
RT processes.";
RL Plant Physiol. 157:1232-1242(2011).
RN [8]
RP INTERACTION WITH GEBP.
RX PubMed=29192025; DOI=10.1104/pp.17.01461;
RA Nietzsche M., Guerra T., Alseekh S., Wiermer M., Sonnewald S., Fernie A.R.,
RA Boernke F.;
RT "STOREKEEPER RELATED1/G-element binding protein (STKR1) interacts with
RT protein kinase SnRK1.";
RL Plant Physiol. 176:1773-1792(2018).
CC -!- FUNCTION: Probable transcription factor. May play redundant roles with
CC GEBP and GPL2 in cytokinin responses by regulating the transcript
CC levels of type-A ARR response genes (PubMed:18162594). Involved in
CC stress responses (PubMed:21875893). Plays a repressive role in cell
CC expansion by counteracting the positive role of CPR5 in this process,
CC but does not regulate cell proliferation or endoreduplication
CC (PubMed:21875893). {ECO:0000269|PubMed:21875893,
CC ECO:0000305|PubMed:18162594}.
CC -!- SUBUNIT: Homo- and heterodimers. Interacts with GEBP, GPL2 and GPL3.
CC Interacts with GEBP (PubMed:29192025). {ECO:0000269|PubMed:18162594,
CC ECO:0000269|PubMed:29192025}.
CC -!- INTERACTION:
CC Q8VYD2; Q8L9Y3: ARR14; NbExp=3; IntAct=EBI-4426914, EBI-1100737;
CC Q8VYD2; Q9SJM4: GPL3; NbExp=3; IntAct=EBI-4426914, EBI-15199331;
CC Q8VYD2; Q05153: SSRP1; NbExp=4; IntAct=EBI-4426914, EBI-15191543;
CC Q8VYD2; Q84JG2: SWI3B; NbExp=3; IntAct=EBI-4426914, EBI-1102271;
CC Q8VYD2; P43273: TGA2; NbExp=6; IntAct=EBI-4426914, EBI-541307;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18162594}.
CC -!- TISSUE SPECIFICITY: Expressed in the apical meristem and young leaf
CC primordia. Detected in the vascular tissues of cotyledons and leaves,
CC in hydathodes and at the base of flowers and siliques, but not in
CC roots. {ECO:0000269|PubMed:18162594}.
CC -!- SIMILARITY: Belongs to the GeBP family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Plant Transcription Factor Database;
CC URL="http://planttfdb.cbi.pku.edu.cn/family.php?sp=Ath&fam=GeBP#family_intro";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC006053; AAD31366.2; -; Genomic_DNA.
DR EMBL; CP002685; AEC07730.1; -; Genomic_DNA.
DR EMBL; AY072164; AAL59986.1; -; mRNA.
DR EMBL; AY096417; AAM20057.1; -; mRNA.
DR EMBL; AY084223; AAM60824.1; -; mRNA.
DR PIR; A84651; A84651.
DR RefSeq; NP_565602.1; NM_128124.3.
DR AlphaFoldDB; Q8VYD2; -.
DR SMR; Q8VYD2; -.
DR IntAct; Q8VYD2; 25.
DR STRING; 3702.AT2G25650.1; -.
DR iPTMnet; Q8VYD2; -.
DR PaxDb; Q8VYD2; -.
DR PRIDE; Q8VYD2; -.
DR ProteomicsDB; 228418; -.
DR EnsemblPlants; AT2G25650.1; AT2G25650.1; AT2G25650.
DR GeneID; 817106; -.
DR Gramene; AT2G25650.1; AT2G25650.1; AT2G25650.
DR KEGG; ath:AT2G25650; -.
DR Araport; AT2G25650; -.
DR TAIR; locus:2050322; AT2G25650.
DR eggNOG; ENOG502R1KX; Eukaryota.
DR HOGENOM; CLU_055192_0_0_1; -.
DR InParanoid; Q8VYD2; -.
DR OMA; EGNDPKF; -.
DR OrthoDB; 1137098at2759; -.
DR PhylomeDB; Q8VYD2; -.
DR PRO; PR:Q8VYD2; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8VYD2; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR InterPro; IPR007592; GEBP.
DR PANTHER; PTHR31662; PTHR31662; 1.
DR Pfam; PF04504; DUF573; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..386
FT /note="GLABROUS1 enhancer-binding protein-like 1"
FT /id="PRO_0000436982"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..375
FT /note="Non-canonical leucine-zipper"
FT /evidence="ECO:0000305|PubMed:18162594"
FT COILED 221..285
FT /evidence="ECO:0000255"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..251
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..285
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 386 AA; 43350 MW; 5AFB1E176F30E5F2 CRC64;
MVTPKQIDFS SCGGGDNSDD TLSHRESPRN PSSKRAAASF AAEAGEETMK KKKKKKKKNL
GPPLIVRIWN EEDELSILKG LVDYRAKTGF NPKIDWDAFY SFLGSSIVAK FSKEQVLSKI
RKLKRRFHVH WEKISEGNDP KFTRSSDSEA FGFSSMIWGQ GEFGNDDGMD KEMVKEHDVN
GNGAAENGTA RIAQENESGE EMLKEHEETL NENGAEEIRD NDETARKAQQ LESESEEEML
KEHEEPFNEN GAENIRDNNG TTQIAQQSES ESEEMLKEHE EVANTELVNE NGAAKTTENG
TTGGKERHDD DDDDELCAVQ DAFEAVMSQG LSGYQKKLQL EKLMNLGTGK RRELSDEWKA
LCVEERRLNI KKLRFSAKLA EAANDS
