STKLN_ARATH
ID STKLN_ARATH Reviewed; 319 AA.
AC O23077;
DT 07-SEP-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Transcription factor STKL2 {ECO:0000303|PubMed:27031427};
DE AltName: Full=Protein Storekeeper-like 2 {ECO:0000303|PubMed:27031427};
GN Name=STKL2 {ECO:0000303|PubMed:27031427};
GN OrderedLocusNames=At4g00250 {ECO:0000312|Araport:AT4G00250};
GN ORFNames=F5I10.12 {ECO:0000312|EMBL:AAF02790.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY.
RX PubMed=12535344; DOI=10.1046/j.1365-313x.2003.01622.x;
RA Curaba J., Herzog M., Vachon G.;
RT "GeBP, the first member of a new gene family in Arabidopsis, encodes a
RT nuclear protein with DNA-binding activity and is regulated by KNAT1.";
RL Plant J. 33:305-317(2003).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION BY GLUCOSE,
RP AND GENE FAMILY.
RX PubMed=27031427; DOI=10.1016/j.plaphy.2016.03.029;
RA Chung M.S., Lee S., Min J.H., Huang P., Ju H.W., Kim C.S.;
RT "Regulation of Arabidopsis thaliana plasma membrane glucose-responsive
RT regulator (AtPGR) expression by A. thaliana storekeeper-like transcription
RT factor, AtSTKL, modulates glucose response in Arabidopsis.";
RL Plant Physiol. Biochem. 104:155-164(2016).
CC -!- FUNCTION: Transcription repressor that binds DNA in a sequence-specific
CC manner, 5'-GCCT-3', to regulate the expression of PGR. Acts as a
CC modulatory component for the glucose-triggered developmental leaf
CC growth process. {ECO:0000269|PubMed:27031427}.
CC -!- INTERACTION:
CC O23077; Q9LST3: At5g60142; NbExp=3; IntAct=EBI-15193247, EBI-15192745;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27031427}.
CC -!- TISSUE SPECIFICITY: Expressed strongly in leaves and flowers, weakly in
CC roots, and very weakly in stems. {ECO:0000269|PubMed:27031427}.
CC -!- INDUCTION: Up-regulated upon glucose treatment.
CC {ECO:0000269|PubMed:27031427}.
CC -!- SIMILARITY: Belongs to the GeBP family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Plant Transcription Factor Database;
CC URL="http://planttfdb.cbi.pku.edu.cn/family.php?sp=Ath&fam=GeBP#family_intro";
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DR EMBL; AF013293; AAB62832.1; -; Genomic_DNA.
DR EMBL; AF195115; AAF02790.1; -; Genomic_DNA.
DR EMBL; AL161471; CAB80783.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE81846.1; -; Genomic_DNA.
DR EMBL; BT003961; AAO42006.1; -; mRNA.
DR EMBL; BT005666; AAO64086.1; -; mRNA.
DR PIR; T01546; T01546.
DR RefSeq; NP_567161.1; NM_116246.3.
DR AlphaFoldDB; O23077; -.
DR SMR; O23077; -.
DR IntAct; O23077; 5.
DR PaxDb; O23077; -.
DR PRIDE; O23077; -.
DR ProteomicsDB; 228304; -.
DR EnsemblPlants; AT4G00250.1; AT4G00250.1; AT4G00250.
DR GeneID; 828046; -.
DR Gramene; AT4G00250.1; AT4G00250.1; AT4G00250.
DR KEGG; ath:AT4G00250; -.
DR Araport; AT4G00250; -.
DR TAIR; locus:2126006; AT4G00250.
DR HOGENOM; CLU_051273_0_0_1; -.
DR InParanoid; O23077; -.
DR OrthoDB; 1137098at2759; -.
DR PhylomeDB; O23077; -.
DR PRO; PR:O23077; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; O23077; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:TAIR.
DR GO; GO:0071333; P:cellular response to glucose stimulus; IMP:TAIR.
DR GO; GO:0010629; P:negative regulation of gene expression; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR InterPro; IPR007592; GEBP.
DR PANTHER; PTHR31662; PTHR31662; 1.
DR Pfam; PF04504; DUF573; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..319
FT /note="Transcription factor STKL2"
FT /id="PRO_0000436988"
FT REGION 1..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 32..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..119
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 319 AA; 35513 MW; C5D42D49D4F59382 CRC64;
MAPLESPATA SSSEVESSSE EIFKSSSEES KPKDPVTVPS SKTLKSPSAA VNSKTDSSDD
SEKQSFVLTR RKKKEGAAES PAVKSGKKRA GEGSTSRDMH VKRVKKEDDN KKANPQRVWS
EEDEISLLQA VIDFKAETGT SPWDHKNAFF DIAKKSISFD VSHVQFFDKI RRLKNKYFVN
RKNKSGESNH DKKCLGLAVL IWGSDGMNVE SPVKKDESIL VKGKANSKEK KVEKPLVIED
EQVILGADSE WFEESFLVPV IANLGLDEYS VKKKWSKVSL ETKKKIQEKM KVVDAKKCEL
LLAEMDVLKD VTSVLAQTN
