STMD1_HUMAN
ID STMD1_HUMAN Reviewed; 276 AA.
AC H3BQB6;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Stathmin domain-containing protein 1;
GN Name=STMND1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 45-158.
RA Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.;
RT "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in
RT human.";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AL138740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DT932726; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS58997.1; -.
DR RefSeq; NP_001177695.1; NM_001190766.1.
DR AlphaFoldDB; H3BQB6; -.
DR SMR; H3BQB6; -.
DR STRING; 9606.ENSP00000455698; -.
DR iPTMnet; H3BQB6; -.
DR PhosphoSitePlus; H3BQB6; -.
DR BioMuta; STMND1; -.
DR MassIVE; H3BQB6; -.
DR PaxDb; H3BQB6; -.
DR PeptideAtlas; H3BQB6; -.
DR PRIDE; H3BQB6; -.
DR ProteomicsDB; 41741; -.
DR Antibodypedia; 77399; 4 antibodies from 4 providers.
DR DNASU; 401236; -.
DR Ensembl; ENST00000536551.6; ENSP00000455698.1; ENSG00000230873.9.
DR GeneID; 401236; -.
DR KEGG; hsa:401236; -.
DR MANE-Select; ENST00000536551.6; ENSP00000455698.1; NM_001190766.2; NP_001177695.1.
DR UCSC; uc021ymc.1; human.
DR CTD; 401236; -.
DR DisGeNET; 401236; -.
DR GeneCards; STMND1; -.
DR HGNC; HGNC:44668; STMND1.
DR HPA; ENSG00000230873; Tissue enhanced (fallopian tube, gallbladder, testis).
DR neXtProt; NX_H3BQB6; -.
DR OpenTargets; ENSG00000230873; -.
DR VEuPathDB; HostDB:ENSG00000230873; -.
DR eggNOG; ENOG502S3US; Eukaryota.
DR GeneTree; ENSGT01030000234597; -.
DR HOGENOM; CLU_089666_0_0_1; -.
DR InParanoid; H3BQB6; -.
DR OMA; SYNQEDD; -.
DR OrthoDB; 1164440at2759; -.
DR TreeFam; TF333434; -.
DR PathwayCommons; H3BQB6; -.
DR BioGRID-ORCS; 401236; 7 hits in 1002 CRISPR screens.
DR ChiTaRS; STMND1; human.
DR GenomeRNAi; 401236; -.
DR Pharos; H3BQB6; Tdark.
DR PRO; PR:H3BQB6; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; H3BQB6; protein.
DR Bgee; ENSG00000230873; Expressed in right uterine tube and 58 other tissues.
DR ExpressionAtlas; H3BQB6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0015631; F:tubulin binding; IBA:GO_Central.
DR GO; GO:0007019; P:microtubule depolymerization; IBA:GO_Central.
DR GO; GO:0031175; P:neuron projection development; IBA:GO_Central.
DR GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IBA:GO_Central.
DR InterPro; IPR000956; Stathmin_fam.
DR InterPro; IPR036002; Stathmin_sf.
DR PANTHER; PTHR10104; PTHR10104; 1.
DR Pfam; PF00836; Stathmin; 1.
DR SUPFAM; SSF101494; SSF101494; 1.
DR PROSITE; PS51663; STATHMIN_3; 1.
PE 2: Evidence at transcript level;
KW Lipoprotein; Myristate; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255"
FT CHAIN 2..276
FT /note="Stathmin domain-containing protein 1"
FT /id="PRO_0000421693"
FT DOMAIN 118..244
FT /note="SLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00998"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 61..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..250
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 276 AA; 30984 MW; D1FC0E49A72EEEB0 CRC64;
MGCGPSQPAE DRRRVRAPKK GWKEEFKADV SVPHTGENCS PRMEAALTKN TVDIAEGLEQ
VQMGSLPGTI SENSPSPSER NRRVNSDLVT NGLINKPQSL ESRERQKSSD ILEELIVQGI
IQSHSKVFRN GESYDVTLTT TEKPLRKPPS RLKKLKIKKQ VKDFTMKDIE EKMEAAEERR
KTKEEEIRKR LRSDRLLPSA NHSDSAELDG AEVAFAKGLQ RVRSAGFEPS DLQGGKPLKR
KKSKCDATLI DRNESDESFG VVESDMSYNQ ADDIVY
