STMN1_CHICK
ID STMN1_CHICK Reviewed; 148 AA.
AC P31395;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Stathmin;
GN Name=STMN1; Synonyms=LAP18;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Retina;
RX PubMed=7916696; DOI=10.1006/exer.1993.1014;
RA Godbout R.;
RT "Identification and characterization of transcripts present at elevated
RT levels in the undifferentiated chick retina.";
RL Exp. Eye Res. 56:95-106(1993).
CC -!- FUNCTION: Involved in the regulation of the microtubule (MT) filament
CC system by destabilizing microtubules. It prevents assembly and promotes
CC disassembly of microtubules (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds to two alpha/beta-tubulin heterodimers. {ECO:0000250}.
CC -!- INTERACTION:
CC P31395; Q8AYS8: KCNMA1; NbExp=3; IntAct=EBI-1636998, EBI-1635766;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC -!- PTM: Many different phosphorylated forms are observed depending on
CC specific combinations among the sites which can be phosphorylated. MAPK
CC is responsible for the phosphorylation of stathmin in response to NGF
CC (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the stathmin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA46450.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X67840; CAA48035.1; -; mRNA.
DR EMBL; X65458; CAA46450.1; ALT_INIT; mRNA.
DR PIR; S31791; S31791.
DR RefSeq; NP_001001858.1; NM_001001858.2.
DR RefSeq; XP_015153089.1; XM_015297603.1.
DR RefSeq; XP_015153090.1; XM_015297604.1.
DR RefSeq; XP_015153091.1; XM_015297605.1.
DR RefSeq; XP_015153092.1; XM_015297606.1.
DR AlphaFoldDB; P31395; -.
DR SMR; P31395; -.
DR BioGRID; 676325; 1.
DR IntAct; P31395; 1.
DR STRING; 9031.ENSGALP00000002235; -.
DR iPTMnet; P31395; -.
DR PaxDb; P31395; -.
DR Ensembl; ENSGALT00000002237; ENSGALP00000002235; ENSGALG00000001475.
DR Ensembl; ENSGALT00000068880; ENSGALP00000048802; ENSGALG00000001475.
DR Ensembl; ENSGALT00000083476; ENSGALP00000063732; ENSGALG00000001475.
DR Ensembl; ENSGALT00000087509; ENSGALP00000058924; ENSGALG00000001475.
DR GeneID; 396057; -.
DR KEGG; gga:396057; -.
DR CTD; 3925; -.
DR VEuPathDB; HostDB:geneid_396057; -.
DR eggNOG; KOG1280; Eukaryota.
DR GeneTree; ENSGT01030000234597; -.
DR HOGENOM; CLU_102026_1_1_1; -.
DR InParanoid; P31395; -.
DR OMA; MAFELVF; -.
DR OrthoDB; 1381987at2759; -.
DR PhylomeDB; P31395; -.
DR TreeFam; TF326935; -.
DR PRO; PR:P31395; -.
DR Proteomes; UP000000539; Chromosome 23.
DR Bgee; ENSGALG00000001475; Expressed in spermatid and 14 other tissues.
DR ExpressionAtlas; P31395; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:Ensembl.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0015631; F:tubulin binding; IBA:GO_Central.
DR GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
DR GO; GO:0061436; P:establishment of skin barrier; IEA:Ensembl.
DR GO; GO:0048012; P:hepatocyte growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007019; P:microtubule depolymerization; IBA:GO_Central.
DR GO; GO:0000281; P:mitotic cytokinesis; IEA:Ensembl.
DR GO; GO:0007052; P:mitotic spindle organization; IEA:Ensembl.
DR GO; GO:1905098; P:negative regulation of guanyl-nucleotide exchange factor activity; IEA:Ensembl.
DR GO; GO:0031115; P:negative regulation of microtubule polymerization; IEA:Ensembl.
DR GO; GO:0035024; P:negative regulation of Rho protein signal transduction; IEA:Ensembl.
DR GO; GO:0051497; P:negative regulation of stress fiber assembly; IEA:Ensembl.
DR GO; GO:0070495; P:negative regulation of thrombin-activated receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0031175; P:neuron projection development; IBA:GO_Central.
DR GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IBA:GO_Central.
DR GO; GO:0009615; P:response to virus; IEA:Ensembl.
DR InterPro; IPR030514; Stathmin_CS.
DR InterPro; IPR000956; Stathmin_fam.
DR InterPro; IPR036002; Stathmin_sf.
DR PANTHER; PTHR10104; PTHR10104; 1.
DR Pfam; PF00836; Stathmin; 1.
DR PIRSF; PIRSF002285; Stathmin; 1.
DR PRINTS; PR00345; STATHMIN.
DR SUPFAM; SSF101494; SSF101494; 1.
DR PROSITE; PS00563; STATHMIN_1; 1.
DR PROSITE; PS01041; STATHMIN_2; 1.
DR PROSITE; PS51663; STATHMIN_3; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Microtubule; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..148
FT /note="Stathmin"
FT /id="PRO_0000182393"
FT DOMAIN 4..145
FT /note="SLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00998"
FT REGION 122..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 41..140
FT /evidence="ECO:0000255"
FT MOD_RES 16
FT /note="Phosphoserine; by PKA"
FT /evidence="ECO:0000250"
FT MOD_RES 38
FT /note="Phosphoserine; by CDK1"
FT /evidence="ECO:0000250"
FT MOD_RES 63
FT /note="Phosphoserine; by PKA"
FT /evidence="ECO:0000250"
SQ SEQUENCE 148 AA; 17082 MW; EDD5BF82A415D5E9 CRC64;
MATSDIQVKE LEKRASGQAF ELILGPRSKE AAPEFPLSPP KKKDLSLEEI QKKLEAAEER
RKSHEAEVLK QLAEKREHEK EVLQKAIEEN NNFSKMAEEK LTHKMEANKE NREAQMAAKL
ERLREKDKHI EEVRKNKEGK DPGEAETN
