STMN3_HUMAN
ID STMN3_HUMAN Reviewed; 180 AA.
AC Q9NZ72; B3KSQ5; B7WP52; B7Z5G4; O75527; Q969Y4;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 3.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Stathmin-3;
DE AltName: Full=SCG10-like protein;
GN Name=STMN3; Synonyms=SCLIP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=9603203; DOI=10.1046/j.1471-4159.1998.70062386.x;
RA Ozon S., Byk T., Sobel A.;
RT "SCLIP: a novel SCG10-like protein of the stathmin family expressed in the
RT nervous system.";
RL J. Neurochem. 70:2386-2396(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10655513; DOI=10.1073/pnas.97.3.1230;
RA Bai C., Connolly B., Metzker M.L., Hilliard C.A., Liu X., Sandig V.,
RA Soderman A., Galloway S.M., Liu Q., Austin C.P., Caskey C.T.;
RT "Overexpression of M68/DcR3 in human gastrointestinal tract tumors
RT independent of gene amplification and its location in a four-gene
RT cluster.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:1230-1235(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Adrenal gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PALMITOYLATION AT CYS-22 AND CYS-24 BY ZDHHC3; ZDHHC7 AND ZDHHC15, AND
RP SUBCELLULAR LOCATION.
RX PubMed=21471001; DOI=10.1091/mbc.e10-10-0824;
RA Levy A.D., Devignot V., Fukata Y., Fukata M., Sobel A., Chauvin S.;
RT "Subcellular Golgi localization of stathmin family proteins is promoted by
RT a specific set of DHHC palmitoyl transferases.";
RL Mol. Biol. Cell 22:1930-1942(2011).
CC -!- FUNCTION: Exhibits microtubule-destabilizing activity, which is
CC antagonized by STAT3. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with STAT3. Interacts with CLU (secreted form); this
CC interaction may act as an important modulator during neuronal
CC differentiation (By similarity). {ECO:0000250,
CC ECO:0000250|UniProtKB:Q9JHU6}.
CC -!- INTERACTION:
CC Q9NZ72; X5D778: ANKRD11; NbExp=3; IntAct=EBI-725557, EBI-17183751;
CC Q9NZ72; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-725557, EBI-8643161;
CC Q9NZ72; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-725557, EBI-11530605;
CC Q9NZ72; O95833: CLIC3; NbExp=3; IntAct=EBI-725557, EBI-10192241;
CC Q9NZ72; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-725557, EBI-11962928;
CC Q9NZ72; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-725557, EBI-744099;
CC Q9NZ72; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-725557, EBI-742102;
CC Q9NZ72; O95872: GPANK1; NbExp=3; IntAct=EBI-725557, EBI-751540;
CC Q9NZ72; O14964: HGS; NbExp=3; IntAct=EBI-725557, EBI-740220;
CC Q9NZ72; Q92993: KAT5; NbExp=3; IntAct=EBI-725557, EBI-399080;
CC Q9NZ72; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-725557, EBI-14069005;
CC Q9NZ72; O76011: KRT34; NbExp=3; IntAct=EBI-725557, EBI-1047093;
CC Q9NZ72; Q8TD10: MIPOL1; NbExp=3; IntAct=EBI-725557, EBI-2548751;
CC Q9NZ72; Q13064: MKRN3; NbExp=3; IntAct=EBI-725557, EBI-2340269;
CC Q9NZ72; Q8NEH6: MNS1; NbExp=3; IntAct=EBI-725557, EBI-743811;
CC Q9NZ72; Q7Z4N8: P4HA3; NbExp=3; IntAct=EBI-725557, EBI-10181968;
CC Q9NZ72; Q16512: PKN1; NbExp=3; IntAct=EBI-725557, EBI-602382;
CC Q9NZ72; Q6IQ23-2: PLEKHA7; NbExp=3; IntAct=EBI-725557, EBI-12069346;
CC Q9NZ72; O15160: POLR1C; NbExp=3; IntAct=EBI-725557, EBI-1055079;
CC Q9NZ72; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-725557, EBI-358489;
CC Q9NZ72; Q8IYX1: TBC1D21; NbExp=3; IntAct=EBI-725557, EBI-12018146;
CC Q9NZ72; Q86WT6-2: TRIM69; NbExp=3; IntAct=EBI-725557, EBI-11525489;
CC Q9NZ72; Q8N3L3: TXLNB; NbExp=3; IntAct=EBI-725557, EBI-6116822;
CC Q9NZ72; P36508: ZNF76; NbExp=3; IntAct=EBI-725557, EBI-7254550;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:21471001}.
CC Cell projection, growth cone {ECO:0000269|PubMed:21471001}. Cell
CC projection, axon {ECO:0000269|PubMed:21471001}. Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q9JHU6}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NZ72-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NZ72-2; Sequence=VSP_056525;
CC -!- TISSUE SPECIFICITY: Neuron specific.
CC -!- PTM: N-terminal palmitoylation promotes specific anchoring to the
CC cytosolic leaflet of Golgi membranes and subsequent vesicular
CC trafficking along dendrites and axons. Neuronal Stathmins are
CC substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.
CC {ECO:0000269|PubMed:21471001}.
CC -!- SIMILARITY: Belongs to the stathmin family. {ECO:0000305}.
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DR EMBL; AF069709; AAD12730.1; -; mRNA.
DR EMBL; AF217796; AAF35245.1; -; Genomic_DNA.
DR EMBL; AK094112; BAG52817.1; -; mRNA.
DR EMBL; AK298903; BAH12900.1; -; mRNA.
DR EMBL; AL353715; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC009381; AAH09381.1; -; mRNA.
DR EMBL; BC025234; AAH25234.1; -; mRNA.
DR CCDS; CCDS13529.1; -. [Q9NZ72-1]
DR CCDS; CCDS63330.1; -. [Q9NZ72-2]
DR RefSeq; NP_001263239.1; NM_001276310.1. [Q9NZ72-2]
DR RefSeq; NP_056978.2; NM_015894.3. [Q9NZ72-1]
DR AlphaFoldDB; Q9NZ72; -.
DR SMR; Q9NZ72; -.
DR BioGRID; 119161; 41.
DR IntAct; Q9NZ72; 27.
DR MINT; Q9NZ72; -.
DR STRING; 9606.ENSP00000359070; -.
DR iPTMnet; Q9NZ72; -.
DR PhosphoSitePlus; Q9NZ72; -.
DR SwissPalm; Q9NZ72; -.
DR BioMuta; STMN3; -.
DR DMDM; 20141809; -.
DR EPD; Q9NZ72; -.
DR jPOST; Q9NZ72; -.
DR MassIVE; Q9NZ72; -.
DR MaxQB; Q9NZ72; -.
DR PaxDb; Q9NZ72; -.
DR PeptideAtlas; Q9NZ72; -.
DR PRIDE; Q9NZ72; -.
DR ProteomicsDB; 6691; -.
DR ProteomicsDB; 83338; -. [Q9NZ72-1]
DR Antibodypedia; 29816; 201 antibodies from 29 providers.
DR DNASU; 50861; -.
DR Ensembl; ENST00000370053.3; ENSP00000359070.1; ENSG00000197457.10. [Q9NZ72-1]
DR Ensembl; ENST00000540534.5; ENSP00000439840.1; ENSG00000197457.10. [Q9NZ72-2]
DR GeneID; 50861; -.
DR KEGG; hsa:50861; -.
DR MANE-Select; ENST00000370053.3; ENSP00000359070.1; NM_015894.4; NP_056978.2.
DR UCSC; uc002yfr.3; human. [Q9NZ72-1]
DR CTD; 50861; -.
DR DisGeNET; 50861; -.
DR GeneCards; STMN3; -.
DR HGNC; HGNC:15926; STMN3.
DR HPA; ENSG00000197457; Tissue enhanced (brain).
DR MIM; 608362; gene.
DR neXtProt; NX_Q9NZ72; -.
DR OpenTargets; ENSG00000197457; -.
DR PharmGKB; PA38049; -.
DR VEuPathDB; HostDB:ENSG00000197457; -.
DR eggNOG; KOG1280; Eukaryota.
DR GeneTree; ENSGT01030000234597; -.
DR HOGENOM; CLU_102026_0_0_1; -.
DR InParanoid; Q9NZ72; -.
DR OMA; YSQPHPK; -.
DR OrthoDB; 1381987at2759; -.
DR PhylomeDB; Q9NZ72; -.
DR TreeFam; TF326935; -.
DR PathwayCommons; Q9NZ72; -.
DR SignaLink; Q9NZ72; -.
DR SIGNOR; Q9NZ72; -.
DR BioGRID-ORCS; 50861; 13 hits in 1077 CRISPR screens.
DR ChiTaRS; STMN3; human.
DR GeneWiki; STMN3; -.
DR GenomeRNAi; 50861; -.
DR Pharos; Q9NZ72; Tbio.
DR PRO; PR:Q9NZ72; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9NZ72; protein.
DR Bgee; ENSG00000197457; Expressed in pons and 152 other tissues.
DR ExpressionAtlas; Q9NZ72; baseline and differential.
DR Genevisible; Q9NZ72; HS.
DR GO; GO:0005737; C:cytoplasm; ISS:HGNC-UCL.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005794; C:Golgi apparatus; IDA:HPA.
DR GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0019904; F:protein domain specific binding; ISS:HGNC-UCL.
DR GO; GO:0015631; F:tubulin binding; IBA:GO_Central.
DR GO; GO:0001835; P:blastocyst hatching; IEA:Ensembl.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; ISS:HGNC-UCL.
DR GO; GO:0007019; P:microtubule depolymerization; IBA:GO_Central.
DR GO; GO:0035021; P:negative regulation of Rac protein signal transduction; ISS:HGNC-UCL.
DR GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR GO; GO:0031175; P:neuron projection development; ISS:HGNC-UCL.
DR GO; GO:0051493; P:regulation of cytoskeleton organization; ISS:HGNC-UCL.
DR GO; GO:0043087; P:regulation of GTPase activity; ISS:HGNC-UCL.
DR GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IBA:GO_Central.
DR InterPro; IPR028835; Stathmin-3.
DR InterPro; IPR030514; Stathmin_CS.
DR InterPro; IPR000956; Stathmin_fam.
DR InterPro; IPR036002; Stathmin_sf.
DR PANTHER; PTHR10104; PTHR10104; 1.
DR PANTHER; PTHR10104:SF17; PTHR10104:SF17; 1.
DR Pfam; PF00836; Stathmin; 1.
DR PIRSF; PIRSF002285; Stathmin; 1.
DR PRINTS; PR00345; STATHMIN.
DR SUPFAM; SSF101494; SSF101494; 1.
DR PROSITE; PS00563; STATHMIN_1; 1.
DR PROSITE; PS01041; STATHMIN_2; 1.
DR PROSITE; PS51663; STATHMIN_3; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell projection; Coiled coil; Cytoplasm;
KW Golgi apparatus; Lipoprotein; Palmitate; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..180
FT /note="Stathmin-3"
FT /id="PRO_0000182402"
FT DOMAIN 38..180
FT /note="SLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00998"
FT REGION 59..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 75..179
FT /evidence="ECO:0000255"
FT MOD_RES 50
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O70166"
FT MOD_RES 60
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O70166"
FT MOD_RES 65
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O70166"
FT MOD_RES 68
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O70166"
FT MOD_RES 72
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O70166"
FT MOD_RES 73
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O70166"
FT MOD_RES 81
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9JHU6"
FT LIPID 22
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 24
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..11
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056525"
FT CONFLICT 72
FT /note="S -> P (in Ref. 1; AAD12730)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 180 AA; 21017 MW; 52F5E8A605FE10D0 CRC64;
MASTISAYKE KMKELSVLSL ICSCFYTQPH PNTVYQYGDM EVKQLDKRAS GQSFEVILKS
PSDLSPESPM LSSPPKKKDT SLEELQKRLE AAEERRKTQE AQVLKQLAER REHEREVLHK
ALEENNNFSR QAEEKLNYKM ELSKEIREAH LAALRERLRE KELHAAEVRR NKEQREEMSG
