STMN4_HUMAN
ID STMN4_HUMAN Reviewed; 189 AA.
AC Q9H169; B7Z2Z7; B7Z4I9; D3DSS8; D3DSS9; G5EA16; Q2TAB9;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Stathmin-4;
DE AltName: Full=Stathmin-like protein B3;
DE Short=RB3;
GN Name=STMN4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Coadwell W.J., Mimmack M.L.;
RT "The nucleotide sequence of the human RB3 gene.";
RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Amygdala;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
RC TISSUE=Brain, and Caudate nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Exhibits microtubule-destabilizing activity. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9H169-2; O95870: ABHD16A; NbExp=3; IntAct=EBI-20117546, EBI-348517;
CC Q9H169-2; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-20117546, EBI-11522760;
CC Q9H169-2; Q96MX0: CMTM3; NbExp=3; IntAct=EBI-20117546, EBI-7247651;
CC Q9H169-2; Q9NR28: DIABLO; NbExp=3; IntAct=EBI-20117546, EBI-517508;
CC Q9H169-2; Q13021: MALL; NbExp=3; IntAct=EBI-20117546, EBI-750078;
CC Q9H169-2; Q9NX47: MARCHF5; NbExp=3; IntAct=EBI-20117546, EBI-2341610;
CC Q9H169-2; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-20117546, EBI-8652744;
CC Q9H169-2; Q9Y6D0: SELENOK; NbExp=3; IntAct=EBI-20117546, EBI-9679163;
CC Q9H169-2; O75971-2: SNAPC5; NbExp=3; IntAct=EBI-20117546, EBI-12004298;
CC Q9H169-2; Q9UNK0: STX8; NbExp=3; IntAct=EBI-20117546, EBI-727240;
CC Q9H169-2; Q9Y228: TRAF3IP3; NbExp=3; IntAct=EBI-20117546, EBI-765817;
CC Q9H169-2; Q6UX27-3: VSTM1; NbExp=3; IntAct=EBI-20117546, EBI-12190699;
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}. Cell projection,
CC growth cone {ECO:0000250}. Cell projection, axon {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q9H169-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H169-2; Sequence=VSP_006279;
CC Name=3;
CC IsoId=Q9H169-3; Sequence=VSP_055279, VSP_055280;
CC Name=4;
CC IsoId=Q9H169-4; Sequence=VSP_006279, VSP_055280;
CC -!- SIMILARITY: Belongs to the stathmin family. {ECO:0000305}.
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DR EMBL; AJ303455; CAC22254.1; -; mRNA.
DR EMBL; AL136568; CAB66503.1; -; mRNA.
DR EMBL; AK295329; BAH12033.1; -; mRNA.
DR EMBL; AK297415; BAH12575.1; -; mRNA.
DR EMBL; AC090150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471080; EAW63562.1; -; Genomic_DNA.
DR EMBL; CH471080; EAW63563.1; -; Genomic_DNA.
DR EMBL; CH471080; EAW63565.1; -; Genomic_DNA.
DR EMBL; CH471080; EAW63567.1; -; Genomic_DNA.
DR EMBL; BC011520; AAH11520.1; -; mRNA.
DR EMBL; BC111001; AAI11002.1; -; mRNA.
DR CCDS; CCDS6055.1; -. [Q9H169-2]
DR CCDS; CCDS64851.1; -. [Q9H169-3]
DR CCDS; CCDS64852.1; -. [Q9H169-1]
DR CCDS; CCDS64854.1; -. [Q9H169-4]
DR RefSeq; NP_001269982.1; NM_001283053.1. [Q9H169-4]
DR RefSeq; NP_001269983.1; NM_001283054.1. [Q9H169-1]
DR RefSeq; NP_001269984.1; NM_001283055.1. [Q9H169-3]
DR RefSeq; NP_110422.2; NM_030795.3. [Q9H169-2]
DR PDB; 6BR1; X-ray; 2.30 A; E=49-189.
DR PDB; 6BRF; X-ray; 2.50 A; E=49-189.
DR PDB; 6BRY; X-ray; 2.70 A; E=49-189.
DR PDB; 6NNG; X-ray; 2.40 A; E=49-189.
DR PDB; 6O5M; X-ray; 2.30 A; E=49-189.
DR PDB; 6O5N; X-ray; 3.00 A; E=49-189.
DR PDB; 6O61; X-ray; 2.60 A; E=49-189.
DR PDB; 6PC4; X-ray; 2.60 A; E=49-189.
DR PDB; 7CPD; X-ray; 2.51 A; E=1-189.
DR PDBsum; 6BR1; -.
DR PDBsum; 6BRF; -.
DR PDBsum; 6BRY; -.
DR PDBsum; 6NNG; -.
DR PDBsum; 6O5M; -.
DR PDBsum; 6O5N; -.
DR PDBsum; 6O61; -.
DR PDBsum; 6PC4; -.
DR PDBsum; 7CPD; -.
DR AlphaFoldDB; Q9H169; -.
DR SMR; Q9H169; -.
DR BioGRID; 123515; 32.
DR IntAct; Q9H169; 28.
DR MINT; Q9H169; -.
DR DrugBank; DB07574; 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE.
DR DrugBank; DB01206; Lomustine.
DR iPTMnet; Q9H169; -.
DR PhosphoSitePlus; Q9H169; -.
DR BioMuta; STMN4; -.
DR DMDM; 17368936; -.
DR jPOST; Q9H169; -.
DR MassIVE; Q9H169; -.
DR MaxQB; Q9H169; -.
DR PeptideAtlas; Q9H169; -.
DR PRIDE; Q9H169; -.
DR ProteomicsDB; 34108; -.
DR ProteomicsDB; 6479; -.
DR ProteomicsDB; 80368; -. [Q9H169-1]
DR ProteomicsDB; 80369; -. [Q9H169-2]
DR Antibodypedia; 10084; 163 antibodies from 23 providers.
DR DNASU; 81551; -.
DR Ensembl; ENST00000265770.11; ENSP00000265770.7; ENSG00000015592.17. [Q9H169-1]
DR Ensembl; ENST00000350889.9; ENSP00000342538.4; ENSG00000015592.17. [Q9H169-2]
DR Ensembl; ENST00000519997.5; ENSP00000428474.1; ENSG00000015592.17. [Q9H169-3]
DR Ensembl; ENST00000523048.5; ENSP00000428428.1; ENSG00000015592.17. [Q9H169-4]
DR GeneID; 81551; -.
DR KEGG; hsa:81551; -.
DR MANE-Select; ENST00000350889.9; ENSP00000342538.4; NM_030795.4; NP_110422.2. [Q9H169-2]
DR UCSC; uc003xfj.5; human. [Q9H169-1]
DR CTD; 81551; -.
DR DisGeNET; 81551; -.
DR GeneCards; STMN4; -.
DR HGNC; HGNC:16078; STMN4.
DR HPA; ENSG00000015592; Group enriched (brain, choroid plexus).
DR neXtProt; NX_Q9H169; -.
DR OpenTargets; ENSG00000015592; -.
DR PharmGKB; PA38089; -.
DR VEuPathDB; HostDB:ENSG00000015592; -.
DR GeneTree; ENSGT01030000234597; -.
DR HOGENOM; CLU_102026_0_1_1; -.
DR InParanoid; Q9H169; -.
DR OMA; TSMPHRR; -.
DR PhylomeDB; Q9H169; -.
DR TreeFam; TF326935; -.
DR PathwayCommons; Q9H169; -.
DR SignaLink; Q9H169; -.
DR BioGRID-ORCS; 81551; 8 hits in 1070 CRISPR screens.
DR GenomeRNAi; 81551; -.
DR Pharos; Q9H169; Tbio.
DR PRO; PR:Q9H169; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q9H169; protein.
DR Bgee; ENSG00000015592; Expressed in cortical plate and 145 other tissues.
DR ExpressionAtlas; Q9H169; baseline and differential.
DR Genevisible; Q9H169; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0015631; F:tubulin binding; IBA:GO_Central.
DR GO; GO:0007019; P:microtubule depolymerization; IBA:GO_Central.
DR GO; GO:0031175; P:neuron projection development; IBA:GO_Central.
DR GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IBA:GO_Central.
DR InterPro; IPR028834; Stathmin-4.
DR InterPro; IPR030514; Stathmin_CS.
DR InterPro; IPR000956; Stathmin_fam.
DR InterPro; IPR036002; Stathmin_sf.
DR PANTHER; PTHR10104; PTHR10104; 1.
DR PANTHER; PTHR10104:SF6; PTHR10104:SF6; 1.
DR Pfam; PF00836; Stathmin; 1.
DR PIRSF; PIRSF002285; Stathmin; 1.
DR PRINTS; PR00345; STATHMIN.
DR SUPFAM; SSF101494; SSF101494; 1.
DR PROSITE; PS00563; STATHMIN_1; 1.
DR PROSITE; PS01041; STATHMIN_2; 1.
DR PROSITE; PS51663; STATHMIN_3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cell projection; Coiled coil;
KW Golgi apparatus; Lipoprotein; Palmitate; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..189
FT /note="Stathmin-4"
FT /id="PRO_0000182406"
FT DOMAIN 48..189
FT /note="SLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00998"
FT REGION 168..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 90..188
FT /evidence="ECO:0000255"
FT MOD_RES 90
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P63043"
FT LIPID 20
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:Q93045"
FT LIPID 22
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:Q93045"
FT VAR_SEQ 1..9
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055279"
FT VAR_SEQ 36
FT /note="E -> EGWCGRQCRRKDESQRKDSADWRERRAQ (in isoform 2 and
FT isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_006279"
FT VAR_SEQ 171..188
FT /note="DKHAEEVRKNKELKEEAS -> EPPAA (in isoform 3 and
FT isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055280"
FT CONFLICT 11
FT /note="K -> M (in Ref. 3; BAH12575)"
FT /evidence="ECO:0000305"
FT STRAND 51..58
FT /evidence="ECO:0007829|PDB:6O5M"
FT STRAND 61..69
FT /evidence="ECO:0007829|PDB:6O5M"
FT HELIX 91..181
FT /evidence="ECO:0007829|PDB:6O5M"
SQ SEQUENCE 189 AA; 22071 MW; 861BBD533D3849AC CRC64;
MTLAAYKEKM KELPLVSLFC SCFLADPLNK SSYKYEADTV DLNWCVISDM EVIELNKCTS
GQSFEVILKP PSFDGVPEFN ASLPRRRDPS LEEIQKKLEA AEERRKYQEA ELLKHLAEKR
EHEREVIQKA IEENNNFIKM AKEKLAQKME SNKENREAHL AAMLERLQEK DKHAEEVRKN
KELKEEASR
