STMN4_MOUSE
ID STMN4_MOUSE Reviewed; 189 AA.
AC P63042; O35414; O35415; O35416;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 31-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Stathmin-4;
DE AltName: Full=Stathmin-like protein B3;
DE Short=RB3;
GN Name=Stmn4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Ozon S., Sobel A.;
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Exhibits microtubule-destabilizing activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}. Cell projection,
CC growth cone {ECO:0000250}. Cell projection, axon {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the stathmin family. {ECO:0000305}.
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DR EMBL; AF105222; AAC96328.1; -; mRNA.
DR EMBL; BC046752; AAH46752.1; -; mRNA.
DR CCDS; CCDS27222.1; -.
DR RefSeq; NP_001297451.1; NM_001310522.1.
DR RefSeq; NP_001297452.1; NM_001310523.1.
DR RefSeq; NP_062649.1; NM_019675.3.
DR PDB; 6KPP; X-ray; 2.75 A; E=49-189.
DR PDB; 6LSM; X-ray; 2.75 A; E=49-189.
DR PDB; 6LSN; X-ray; 2.44 A; E=49-189.
DR PDB; 7CNM; X-ray; 2.44 A; E=49-189.
DR PDB; 7CNN; X-ray; 2.50 A; E=49-189.
DR PDB; 7CNO; X-ray; 2.50 A; E=49-189.
DR PDB; 7DAD; X-ray; 2.85 A; E=49-189.
DR PDB; 7DAE; X-ray; 2.39 A; E=49-189.
DR PDB; 7DAF; X-ray; 2.40 A; E=49-189.
DR PDB; 7DB9; X-ray; 2.85 A; E=49-189.
DR PDB; 7DBA; X-ray; 2.46 A; E=49-189.
DR PDB; 7DBB; X-ray; 2.81 A; E=49-189.
DR PDB; 7DBC; X-ray; 2.40 A; E=49-189.
DR PDB; 7DBD; X-ray; 3.09 A; E=49-189.
DR PDBsum; 6KPP; -.
DR PDBsum; 6LSM; -.
DR PDBsum; 6LSN; -.
DR PDBsum; 7CNM; -.
DR PDBsum; 7CNN; -.
DR PDBsum; 7CNO; -.
DR PDBsum; 7DAD; -.
DR PDBsum; 7DAE; -.
DR PDBsum; 7DAF; -.
DR PDBsum; 7DB9; -.
DR PDBsum; 7DBA; -.
DR PDBsum; 7DBB; -.
DR PDBsum; 7DBC; -.
DR PDBsum; 7DBD; -.
DR AlphaFoldDB; P63042; -.
DR SMR; P63042; -.
DR STRING; 10090.ENSMUSP00000074113; -.
DR iPTMnet; P63042; -.
DR PhosphoSitePlus; P63042; -.
DR MaxQB; P63042; -.
DR PaxDb; P63042; -.
DR PRIDE; P63042; -.
DR ProteomicsDB; 257496; -.
DR Antibodypedia; 10084; 163 antibodies from 23 providers.
DR DNASU; 56471; -.
DR Ensembl; ENSMUST00000074523; ENSMUSP00000074113; ENSMUSG00000022044.
DR GeneID; 56471; -.
DR KEGG; mmu:56471; -.
DR UCSC; uc007ukf.1; mouse.
DR CTD; 81551; -.
DR MGI; MGI:1931224; Stmn4.
DR VEuPathDB; HostDB:ENSMUSG00000022044; -.
DR eggNOG; KOG1280; Eukaryota.
DR GeneTree; ENSGT01030000234597; -.
DR HOGENOM; CLU_102026_0_1_1; -.
DR InParanoid; P63042; -.
DR OMA; TSMPHRR; -.
DR OrthoDB; 1381987at2759; -.
DR PhylomeDB; P63042; -.
DR TreeFam; TF326935; -.
DR BioGRID-ORCS; 56471; 2 hits in 73 CRISPR screens.
DR PRO; PR:P63042; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; P63042; protein.
DR Bgee; ENSMUSG00000022044; Expressed in embryonic brain and 132 other tissues.
DR ExpressionAtlas; P63042; baseline and differential.
DR Genevisible; P63042; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0015631; F:tubulin binding; IBA:GO_Central.
DR GO; GO:0007019; P:microtubule depolymerization; IBA:GO_Central.
DR GO; GO:0031175; P:neuron projection development; IBA:GO_Central.
DR GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IBA:GO_Central.
DR InterPro; IPR028834; Stathmin-4.
DR InterPro; IPR030514; Stathmin_CS.
DR InterPro; IPR000956; Stathmin_fam.
DR InterPro; IPR036002; Stathmin_sf.
DR PANTHER; PTHR10104; PTHR10104; 1.
DR PANTHER; PTHR10104:SF6; PTHR10104:SF6; 1.
DR Pfam; PF00836; Stathmin; 1.
DR PIRSF; PIRSF002285; Stathmin; 1.
DR PRINTS; PR00345; STATHMIN.
DR SUPFAM; SSF101494; SSF101494; 1.
DR PROSITE; PS00563; STATHMIN_1; 1.
DR PROSITE; PS01041; STATHMIN_2; 1.
DR PROSITE; PS51663; STATHMIN_3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell projection; Coiled coil; Golgi apparatus; Lipoprotein;
KW Palmitate; Phosphoprotein; Reference proteome.
FT CHAIN 1..189
FT /note="Stathmin-4"
FT /id="PRO_0000182407"
FT DOMAIN 48..189
FT /note="SLD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00998"
FT REGION 168..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 90..189
FT /evidence="ECO:0000255"
FT MOD_RES 90
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P63043"
FT LIPID 20
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 22
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT STRAND 51..58
FT /evidence="ECO:0007829|PDB:7DAE"
FT STRAND 61..69
FT /evidence="ECO:0007829|PDB:7DAE"
FT HELIX 91..187
FT /evidence="ECO:0007829|PDB:7DAE"
SQ SEQUENCE 189 AA; 22087 MW; 4D61AAE5E8131551 CRC64;
MTLAAYKEKM KELPLVSLFC SCFLSDPLNK SSYKYEADTV DLNWCVISDM EVIELNKCTS
GQSFEVILKP PSFDGVPEFN ASLPRRRDPS LEEIQKKLEA AEERRKYQEA ELLKHLAEKR
EHEREVIQKA IEENNNFIKM AKEKLAQKME SNKENREAHL AAMLERLQEK DKHAEEVRKN
KELKEEASR
