STMP1_DANRE
ID STMP1_DANRE Reviewed; 46 AA.
AC B3DFW5;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 65.
DE RecName: Full=Short transmembrane mitochondrial protein 1 {ECO:0000303|PubMed:23073385};
GN Name=stmp1 {ECO:0000303|PubMed:23073385};
GN ORFNames=si:dkey-13i19.8 {ECO:0000303|PubMed:23594743};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=23073385; DOI=10.1152/physiolgenomics.00079.2012;
RA Zhang D., Xi Y., Coccimiglio M.L., Mennigen J.A., Jonz M.G., Ekker M.,
RA Trudeau V.L.;
RT "Functional prediction and physiological characterization of a novel short
RT trans-membrane protein 1 as a subunit of mitochondrial respiratory
RT complexes.";
RL Physiol. Genomics 44:1133-1140(2012).
CC -!- FUNCTION: Microprotein involved in mitochondrial respiratory chain
CC complex III (ubiquinol-cytochrome c oxidoreductase) and complex IV
CC (mitochondrial cytochrome c oxidase complex) assembly (By similarity).
CC Required for the formation of mitochondrial supercomplexes (SCs) (By
CC similarity). Also required for the activation of the NLRP3 inflammasome
CC (By similarity). {ECO:0000250|UniProtKB:E0CX11,
CC ECO:0000250|UniProtKB:P0DP99}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:E0CX11}; Single-pass membrane protein
CC {ECO:0000255}. Mitochondrion outer membrane
CC {ECO:0000250|UniProtKB:P0DP99}; Single-pass membrane protein
CC {ECO:0000255}. Mitochondrion intermembrane space
CC {ECO:0000250|UniProtKB:P0DP99}.
CC -!- TISSUE SPECIFICITY: Widely expressed. Expressed more abundantly in
CC brain compared with other tissues such as heart, muscle and liver.
CC {ECO:0000269|PubMed:23073385}.
CC -!- DEVELOPMENTAL STAGE: Stable expression throughout embryogenesis with
CC more abundance after 5 days post-fertilization (dpf).
CC {ECO:0000269|PubMed:23073385}.
CC -!- DISRUPTION PHENOTYPE: Morpholino knockdown of the protein leads to
CC various development defects, including smaller eye, abnormal head
CC shape, malformations of the jaw, cardiac edema and a delayed yolk sac
CC resorption (PubMed:23073385). Most animals die by 1 week of age
CC (PubMed:23073385). {ECO:0000269|PubMed:23073385}.
CC -!- SIMILARITY: Belongs to the STMP1 family. {ECO:0000305}.
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DR EMBL; BX649476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC162188; AAI62188.1; -; mRNA.
DR EMBL; BC162192; AAI62192.1; -; mRNA.
DR RefSeq; NP_001289563.1; NM_001302634.1.
DR AlphaFoldDB; B3DFW5; -.
DR SMR; B3DFW5; -.
DR Ensembl; ENSDART00000134054; ENSDARP00000134335; ENSDARG00000093058.
DR GeneID; 100170826; -.
DR KEGG; dre:100170826; -.
DR CTD; 647087; -.
DR ZFIN; ZDB-GENE-041210-156; stmp1.
DR GeneTree; ENSGT00550000076278; -.
DR HOGENOM; CLU_3177783_0_0_1; -.
DR OrthoDB; 1635137at2759; -.
DR PRO; PR:B3DFW5; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 4.
DR Bgee; ENSDARG00000093058; Expressed in early embryo and 28 other tissues.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005758; C:mitochondrial intermembrane space; ISS:UniProtKB.
DR GO; GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
DR GO; GO:0005746; C:mitochondrial respirasome; IMP:ZFIN.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0097250; P:mitochondrial respirasome assembly; ISS:UniProtKB.
DR GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; ISS:UniProtKB.
DR GO; GO:0032731; P:positive regulation of interleukin-1 beta production; ISS:UniProtKB.
DR GO; GO:1900227; P:positive regulation of NLRP3 inflammasome complex assembly; ISS:UniProtKB.
DR InterPro; IPR027854; STMP1.
DR PANTHER; PTHR47709; PTHR47709; 1.
DR Pfam; PF15054; DUF4535; 1.
PE 2: Evidence at transcript level;
KW Immunity; Innate immunity; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Mitochondrion outer membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..46
FT /note="Short transmembrane mitochondrial protein 1"
FT /id="PRO_0000441871"
FT TRANSMEM 7..23
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 46 AA; 5246 MW; BA473D9DF744D8E4 CRC64;
MMQFILGFTL GNVVGMYLAQ NYEVPNISKK IEAFKKDVEA KKKPPE
