STMP1_HUMAN
ID STMP1_HUMAN Reviewed; 47 AA.
AC E0CX11;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Short transmembrane mitochondrial protein 1 {ECO:0000303|PubMed:23073385};
GN Name=STMP1 {ECO:0000303|PubMed:23073385, ECO:0000312|HGNC:HGNC:41909};
GN Synonyms=C7orf73 {ECO:0000312|HGNC:HGNC:41909};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP IDENTIFICATION.
RX PubMed=23073385; DOI=10.1152/physiolgenomics.00079.2012;
RA Zhang D., Xi Y., Coccimiglio M.L., Mennigen J.A., Jonz M.G., Ekker M.,
RA Trudeau V.L.;
RT "Functional prediction and physiological characterization of a novel short
RT trans-membrane protein 1 as a subunit of mitochondrial respiratory
RT complexes.";
RL Physiol. Genomics 44:1133-1140(2012).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [4]
RP TISSUE SPECIFICITY, AND INDUCTION BY TLR LIGANDS.
RX PubMed=31836654; DOI=10.4049/jimmunol.1900791;
RA Bhatta A., Atianand M., Jiang Z., Crabtree J., Blin J., Fitzgerald K.A.;
RT "A Mitochondrial Micropeptide Is Required for Activation of the Nlrp3
RT Inflammasome.";
RL J. Immunol. 204:428-437(2020).
RN [5]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=35450818; DOI=10.1016/j.ymthe.2022.04.012;
RA Sang Y., Liu J.Y., Wang F.Y., Luo X.Y., Chen Z.Q., Zhuang S.M., Zhu Y.;
RT "Mitochondrial micropeptide STMP1 promotes G1/S transition by enhancing
RT mitochondrial complex IV activity.";
RL Mol. Ther. 0:0-0(2022).
CC -!- FUNCTION: Microprotein involved in mitochondrial respiratory chain
CC complex III (ubiquinol-cytochrome c oxidoreductase) and complex IV
CC (mitochondrial cytochrome c oxidase complex) assembly
CC (PubMed:35450818). Required for the formation of mitochondrial
CC supercomplexes (SCs) (PubMed:35450818). Also required for the
CC activation of the NLRP3 inflammasome (By similarity).
CC {ECO:0000250|UniProtKB:P0DP99, ECO:0000269|PubMed:35450818}.
CC -!- SUBUNIT: Interacts with components of the ubiquinol-cytochrome c
CC oxidoreductase (cytochrome b-c1 complex, complex III, CIII), such as
CC UQCRC1/QCR1, UQCRC2/QCR2 and UQCR10/QCR9 (By similarity). Interacts
CC with components of the cytochrome c oxidase (mitochondrial respiratory
CC chain complex IV) complex, such as MT-CO2 (PubMed:35450818).
CC {ECO:0000250|UniProtKB:P0DP99, ECO:0000269|PubMed:35450818}.
CC -!- INTERACTION:
CC E0CX11; O43765: SGTA; NbExp=3; IntAct=EBI-18397783, EBI-347996;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:35450818}; Single-pass membrane protein
CC {ECO:0000255}. Mitochondrion outer membrane
CC {ECO:0000250|UniProtKB:P0DP99}; Single-pass membrane protein
CC {ECO:0000255}. Mitochondrion intermembrane space
CC {ECO:0000250|UniProtKB:P0DP99}.
CC -!- TISSUE SPECIFICITY: Expressed in monocytes and dendritic cells.
CC {ECO:0000269|PubMed:31836654}.
CC -!- INDUCTION: Down-regulated by bacterial lipopolysaccharide (LPS) in
CC monocytes and dendritic cells. {ECO:0000269|PubMed:31836654}.
CC -!- SIMILARITY: Belongs to the STMP1 family. {ECO:0000305}.
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DR EMBL; AC091736; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC093107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS55168.1; -.
DR RefSeq; NP_001124401.1; NM_001130929.1.
DR AlphaFoldDB; E0CX11; -.
DR SMR; E0CX11; -.
DR BioGRID; 571873; 1.
DR IntAct; E0CX11; 2.
DR STRING; 9606.ENSP00000425996; -.
DR PhosphoSitePlus; E0CX11; -.
DR BioMuta; STMP1; -.
DR EPD; E0CX11; -.
DR MassIVE; E0CX11; -.
DR MaxQB; E0CX11; -.
DR PaxDb; E0CX11; -.
DR PeptideAtlas; E0CX11; -.
DR PRIDE; E0CX11; -.
DR ProteomicsDB; 15190; -.
DR TopDownProteomics; E0CX11; -.
DR Antibodypedia; 77172; 4 antibodies from 4 providers.
DR DNASU; 647087; -.
DR Ensembl; ENST00000507606.3; ENSP00000425996.1; ENSG00000243317.8.
DR GeneID; 647087; -.
DR KEGG; hsa:647087; -.
DR MANE-Select; ENST00000507606.3; ENSP00000425996.1; NM_001130929.2; NP_001124401.1.
DR UCSC; uc003vsy.4; human.
DR CTD; 647087; -.
DR DisGeNET; 647087; -.
DR GeneCards; STMP1; -.
DR HGNC; HGNC:41909; STMP1.
DR HPA; ENSG00000243317; Low tissue specificity.
DR MIM; 618755; gene.
DR neXtProt; NX_E0CX11; -.
DR OpenTargets; ENSG00000243317; -.
DR VEuPathDB; HostDB:ENSG00000243317; -.
DR eggNOG; ENOG502S7PN; Eukaryota.
DR GeneTree; ENSGT00550000076278; -.
DR HOGENOM; CLU_3177783_0_0_1; -.
DR InParanoid; E0CX11; -.
DR OrthoDB; 1635137at2759; -.
DR PhylomeDB; E0CX11; -.
DR PathwayCommons; E0CX11; -.
DR SignaLink; E0CX11; -.
DR BioGRID-ORCS; 647087; 9 hits in 701 CRISPR screens.
DR ChiTaRS; C7orf73; human.
DR GenomeRNAi; 647087; -.
DR Pharos; E0CX11; Tdark.
DR PRO; PR:E0CX11; -.
DR Proteomes; UP000005640; Chromosome 7.
DR Bgee; ENSG00000243317; Expressed in pancreatic ductal cell and 190 other tissues.
DR ExpressionAtlas; E0CX11; baseline and differential.
DR Genevisible; E0CX11; HS.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IDA:UniProtKB.
DR GO; GO:0005758; C:mitochondrial intermembrane space; ISS:UniProtKB.
DR GO; GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
DR GO; GO:0005746; C:mitochondrial respirasome; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0033617; P:mitochondrial cytochrome c oxidase assembly; IMP:UniProtKB.
DR GO; GO:0097250; P:mitochondrial respirasome assembly; IMP:UniProtKB.
DR GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; ISS:UniProtKB.
DR GO; GO:0032731; P:positive regulation of interleukin-1 beta production; ISS:UniProtKB.
DR GO; GO:1900227; P:positive regulation of NLRP3 inflammasome complex assembly; ISS:UniProtKB.
DR InterPro; IPR027854; STMP1.
DR PANTHER; PTHR47709; PTHR47709; 1.
DR Pfam; PF15054; DUF4535; 1.
PE 1: Evidence at protein level;
KW Immunity; Innate immunity; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Mitochondrion outer membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..47
FT /note="Short transmembrane mitochondrial protein 1"
FT /evidence="ECO:0000255"
FT /id="PRO_0000413534"
FT TRANSMEM 7..23
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 47 AA; 5265 MW; A2B4B037CBED539F CRC64;
MLQFLLGFTL GNVVGMYLAQ NYDIPNLAKK LEEIKKDLDA KKKPPSA
