STM_DANRE
ID STM_DANRE Reviewed; 613 AA.
AC A2VD23; Q6UDM5;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Protein starmaker;
DE Flags: Precursor;
GN Name=stm; ORFNames=si:ch211-80h18.3;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, SUBCELLULAR
RP LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=14551434; DOI=10.1126/science.1088443;
RA Soellner C., Burghammer M., Busch-Nentwich E., Berger J., Schwarz H.,
RA Riekel C., Nicolson T.;
RT "Control of crystal size and lattice formation by starmaker in otolith
RT biomineralization.";
RL Science 302:282-286(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential for the formation of otoliths in the inner ear of
CC developing larvae and for the perception of gravity and acceleration.
CC May be one of the organic components of the ortholiths.
CC {ECO:0000269|PubMed:14551434}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14551434}.
CC Note=Detected on otoliths and the apical surface of epithelial cells in
CC the otic placode in larvae 24 hours after fertilization.
CC -!- DEVELOPMENTAL STAGE: Detected in the otic placode and the pineal gland
CC in embryos 24 hours after fertilization. Detected in the sensory hair
CC epithelium along the entire length of the lateral line organ in larvae
CC 72 hours post fertilization. Restricted mainly to neuroepithelial
CC patches in the ear of larvae 72 hours post fertilization.
CC {ECO:0000269|PubMed:14551434}.
CC -!- MISCELLANEOUS: Otoliths are structures composed of proteins and calcium
CC carbonate that are found in the fish inner ear in contact with the otic
CC epithelium. They are essential for the perception of gravity and
CC acceleration.
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DR EMBL; AY372242; AAQ93680.1; -; mRNA.
DR EMBL; CT574549; CAN87876.1; -; Genomic_DNA.
DR EMBL; BC129155; AAI29156.1; -; mRNA.
DR RefSeq; NP_942112.2; NM_198817.2.
DR AlphaFoldDB; A2VD23; -.
DR STRING; 7955.ENSDARP00000095945; -.
DR PaxDb; A2VD23; -.
DR Ensembl; ENSDART00000105174; ENSDARP00000095945; ENSDARG00000035694.
DR GeneID; 386700; -.
DR KEGG; dre:386700; -.
DR CTD; 20882; -.
DR ZFIN; ZDB-GENE-031112-4; stm.
DR eggNOG; KOG1808; Eukaryota.
DR GeneTree; ENSGT00990000209556; -.
DR HOGENOM; CLU_445454_0_0_1; -.
DR OMA; HHDRDKE; -.
DR TreeFam; TF343945; -.
DR PRO; PR:A2VD23; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 19.
DR Bgee; ENSDARG00000035694; Expressed in swim bladder and 49 other tissues.
DR ExpressionAtlas; A2VD23; baseline and differential.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0009590; P:detection of gravity; IMP:ZFIN.
DR GO; GO:0043049; P:otic placode formation; IEP:ZFIN.
DR GO; GO:0045299; P:otolith mineralization; IDA:ZFIN.
DR GO; GO:0032474; P:otolith morphogenesis; IMP:ZFIN.
DR DisProt; DP00584; -.
PE 2: Evidence at transcript level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..613
FT /note="Protein starmaker"
FT /id="PRO_0000315278"
FT REGION 42..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..500
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..524
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..558
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..573
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..604
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 144
FT /note="Q -> K (in Ref. 1; AAQ93680)"
FT /evidence="ECO:0000305"
FT CONFLICT 473
FT /note="D -> E (in Ref. 1; AAQ93680)"
FT /evidence="ECO:0000305"
FT CONFLICT 606
FT /note="R -> S (in Ref. 1; AAQ93680)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 613 AA; 66175 MW; A7EB6B2FBADD2B0F CRC64;
MLSRTVFVPL ILAFVGVSIS APVSNNNGTD NDESAADQRH IFTVQFNVGT PAPADGDSVT
TDGKDSAEKN EAPGDSSDTT EKPGTTDGKD SAEQHGVTTD GKDEAEQHGV TTDGQDSAEK
RGEADGAPDK PDTQNGTDDT DSDQETDASH HKTGDSDENK DKPSAEDHTD GNHAGKDSTD
SKESPDTTDK PEGPDSDSAP DGDSASAEKT DSDHSPDEDA NKSSTEADKD DTSDKDSSQT
DEKHDSDASD KDEKHEDKDE KSDEKDSSKD SEDKSQEKSD KSDDGSNSEA DEQKESVESK
DHDSDSQDSD SAEKKEKHDD KDQDSSDSAD SKDSDEDKDK DHSEQKDSED HEHKEKHTKD
KEEHKDSDEG KDDEDKSKSD EHDKDESESK EASKSDESEQ EEKKDDKSDS DNSSRDSHSD
SDSDSHSDSD SDSHSDSHSD SDSDSHSDSD SDSDSDSDSD SDSDSDSNSR DKDEKKDKSS
ESRDEDSSDS DSKSNSESSE TAEEDTNDDK DSSVEKDKTD SSDSASVEAN DSDDEHDDDS
KDATPSSEDH TAEKTDEDSH DVSDDDDDID AHDDEAGVEH GTDEASKPHQ EPDHHDDTTH
GSDDGRKTSM PIS
