ID   STN1_AILME              Reviewed;         367 AA.
AC   D2GXY4;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 2.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=CST complex subunit STN1 {ECO:0000250|UniProtKB:Q9H668};
DE   AltName: Full=Oligonucleotide/oligosaccharide-binding fold-containing protein 1;
DE   AltName: Full=Suppressor of cdc thirteen homolog;
GN   Name=STN1 {ECO:0000250|UniProtKB:Q9H668}; Synonyms=OBFC1;
GN   ORFNames=PANDA_001803;
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX   NCBI_TaxID=9646;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA   Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA   Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA   Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA   Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA   Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA   Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA   Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA   Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA   Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA   Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA   Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA   Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA   Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA   Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
CC   -!- FUNCTION: Component of the CST complex, a complex that binds to single-
CC       stranded DNA and is required to protect telomeres from DNA degradation.
CC       The CST complex binds single-stranded DNA with high affinity in a
CC       sequence-independent manner, while isolated subunits bind DNA with low
CC       affinity by themselves. In addition to telomere protection, the CST
CC       complex has probably a more general role in DNA metabolism at non-
CC       telomeric sites (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the CST complex, composed of TEN1, CTC1 and STN1.
CC       Interacts with TEN1 and CTC1; the interaction is direct. Interacts with
CC       ACD/TPP1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, telomere
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the STN1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EFB27672.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; GL192371; EFB27672.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; D2GXY4; -.
DR   SMR; D2GXY4; -.
DR   STRING; 9646.ENSAMEP00000018988; -.
DR   eggNOG; KOG3108; Eukaryota.
DR   InParanoid; D2GXY4; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0000781; C:chromosome, telomeric region; ISS:UniProtKB.
DR   GO; GO:1990879; C:CST complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0043047; F:single-stranded telomeric DNA binding; ISS:UniProtKB.
DR   GO; GO:0016233; P:telomere capping; IEA:InterPro.
DR   GO; GO:0000723; P:telomere maintenance; ISS:UniProtKB.
DR   GO; GO:0010833; P:telomere maintenance via telomere lengthening; ISS:UniProtKB.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.10.980; -; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   InterPro; IPR015253; CST_STN1_C.
DR   InterPro; IPR042082; CST_Stn1_wHTH1_sf.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR004365; NA-bd_OB_tRNA.
DR   InterPro; IPR040260; RFA2-like.
DR   InterPro; IPR014647; Stn1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13989; PTHR13989; 1.
DR   Pfam; PF09170; STN1_2; 1.
DR   Pfam; PF01336; tRNA_anti-codon; 1.
DR   PIRSF; PIRSF036950; UCP036950; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
PE   3: Inferred from homology;
KW   Chromosome; DNA-binding; Nucleus; Reference proteome; Telomere.
FT   CHAIN           1..367
FT                   /note="CST complex subunit STN1"
FT                   /id="PRO_0000392986"
FT   DNA_BIND        56..154
FT                   /note="OB"
FT   REGION          190..294
FT                   /note="Winged helix-turn-helix (wHTH) 1"
FT                   /evidence="ECO:0000250"
FT   REGION          295..367
FT                   /note="Winged helix-turn-helix (wHTH) 1"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   367 AA;  41671 MW;  7307B62BBEF88D6D CRC64;
     MQPESSQREE TPSLLWGLDP VFLAFAKLYI GDILDLKESR QVPGVFFYNG HPIKQVEILG
     TVIGRREKDA FYSYGVDDGT GVINCICWKK SNNAAPSSAA PALGVLNLTS QLKKLQETIE
     QKTKIEIGDI VQIRGYVHTY REEREIRVTT YYKVDDPVCN IQIARMLELP SIYRKVYDQP
     FCSPALEQER AFSDPSALDL ASLTRLLSER AKEFLAENKV QTFYQQELEI VESLLSLANQ
     PVIHGAGPEQ GDSKSDTTSK AIHSIFKNAI QLLQEKGFVF QKDDGFDKLY YVTREDKELH
     RKIHHIIQED CQKPNHAEKG CHFQHILACA RLSVSPDLSE GVLQQVLELL EDQSDIISTT
     EHYYTAF