STN1_LITCT
ID STN1_LITCT Reviewed; 336 AA.
AC C1C4M3;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 26-MAY-2009, sequence version 1.
DT 25-MAY-2022, entry version 42.
DE RecName: Full=CST complex subunit STN1 {ECO:0000250|UniProtKB:Q9H668};
DE AltName: Full=Oligonucleotide/oligosaccharide-binding fold-containing protein 1;
DE AltName: Full=Suppressor of cdc thirteen homolog;
GN Name=stn1 {ECO:0000250|UniProtKB:Q9H668}; Synonyms=obfc1;
OS Lithobates catesbeianus (American bullfrog) (Rana catesbeiana).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX NCBI_TaxID=8400;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Helbing C.C., Veldhoen N., Leong J., Koop B.F.;
RT "Rana catesbeiana ESTs and full-length cDNAs.";
RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the CST complex proposed to act as a specialized
CC replication factor promoting DNA replication under conditions of
CC replication stress or natural replication barriers such as the telomere
CC duplex. The CST complex binds single-stranded DNA with high affinity in
CC a sequence-independent manner, while isolated subunits bind DNA with
CC low affinity by themselves. Initially the CST complex has been proposed
CC to protect telomeres from DNA degradation. However, the CST complex has
CC been shown to be involved in several aspects of telomere replication.
CC {ECO:0000250|UniProtKB:Q9H668}.
CC -!- SUBUNIT: Component of the CST complex. {ECO:0000250|UniProtKB:Q9H668}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H668}.
CC Chromosome, telomere {ECO:0000250|UniProtKB:Q9H668}.
CC -!- SIMILARITY: Belongs to the CTC1 family. {ECO:0000305}.
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DR EMBL; BT081802; ACO51933.1; -; mRNA.
DR AlphaFoldDB; C1C4M3; -.
DR SMR; C1C4M3; -.
DR GO; GO:0000781; C:chromosome, telomeric region; ISS:UniProtKB.
DR GO; GO:1990879; C:CST complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0043047; F:single-stranded telomeric DNA binding; ISS:UniProtKB.
DR GO; GO:0016233; P:telomere capping; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; ISS:UniProtKB.
DR GO; GO:0010833; P:telomere maintenance via telomere lengthening; ISS:UniProtKB.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.10.980; -; 1.
DR Gene3D; 2.40.50.140; -; 2.
DR InterPro; IPR015253; CST_STN1_C.
DR InterPro; IPR042082; CST_Stn1_wHTH1_sf.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR040260; RFA2-like.
DR InterPro; IPR014647; Stn1.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13989; PTHR13989; 1.
DR Pfam; PF09170; STN1_2; 1.
DR PIRSF; PIRSF036950; UCP036950; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
PE 2: Evidence at transcript level;
KW Chromosome; DNA-binding; Nucleus; Telomere.
FT CHAIN 1..336
FT /note="CST complex subunit STN1"
FT /id="PRO_0000392990"
FT DNA_BIND 49..126
FT /note="OB"
FT REGION 162..263
FT /note="Winged helix-turn-helix (wHTH) 1"
FT /evidence="ECO:0000250"
FT REGION 264..336
FT /note="Winged helix-turn-helix (wHTH) 2"
FT /evidence="ECO:0000250"
SQ SEQUENCE 336 AA; 38854 MW; 538CAE461DF3043D CRC64;
MKEPPSLLWG LDPVFLSHAR LYIKDILELK ESNQVPGIFF YKDHPIKQVD ILGTVVCVRE
KDAFYSYGDV HRSTSGANDL DGLVQELHRQ ESSKAKMEIG DVIRVRGYIK VFRMQREVVA
SIFYKVDDPT LDMQIMRMLE LPYLYKHAYD KPFILPEDMT NQSQEQPNQA VLQRSGLISL
LSEKIMNFVK ENTIYNFYLP ELESMPSLLS EATNPHYITE SDSNVSSSSR EIRSLFKEAI
HILLKRGIVY QKGQNKDVYY VTDHDKELHK LTLNMIKQDC SRQGHAEKGC HFLHILNCVQ
QDFGSCINEA ILQRVINALE QNSDIVSTME KYYTAF
