STN1_SCHPO
ID STN1_SCHPO Reviewed; 325 AA.
AC Q0E7J7;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Protein stn1;
GN Name=stn1; ORFNames=SPBC409.12c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION, INTERACTION WITH TEN1, AND SUBCELLULAR LOCATION.
RX PubMed=17715303; DOI=10.1073/pnas.0705497104;
RA Martin V., Du L.-L., Rozenzhak S., Russell P.;
RT "Protection of telomeres by a conserved Stn1-Ten1 complex.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:14038-14043(2007).
CC -!- FUNCTION: Required for telomere maintenance.
CC {ECO:0000269|PubMed:17715303}.
CC -!- SUBUNIT: Interacts with ten1. {ECO:0000269|PubMed:17715303}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17715303}.
CC Chromosome, telomere {ECO:0000269|PubMed:17715303}.
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DR EMBL; CU329671; CAL44730.1; -; Genomic_DNA.
DR RefSeq; XP_001713126.1; XM_001713074.2.
DR PDB; 3KF6; X-ray; 1.65 A; A=2-159.
DR PDBsum; 3KF6; -.
DR AlphaFoldDB; Q0E7J7; -.
DR SMR; Q0E7J7; -.
DR BioGRID; 277567; 23.
DR DIP; DIP-38936N; -.
DR IntAct; Q0E7J7; 4.
DR MINT; Q0E7J7; -.
DR STRING; 4896.SPBC409.12c.1; -.
DR iPTMnet; Q0E7J7; -.
DR PaxDb; Q0E7J7; -.
DR EnsemblFungi; SPBC409.12c.1; SPBC409.12c.1:pep; SPBC409.12c.
DR PomBase; SPBC409.12c; stn1.
DR VEuPathDB; FungiDB:SPBC409.12c; -.
DR HOGENOM; CLU_845089_0_0_1; -.
DR InParanoid; Q0E7J7; -.
DR OMA; RWNPMFI; -.
DR EvolutionaryTrace; Q0E7J7; -.
DR PRO; PR:Q0E7J7; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0140445; C:chromosome, telomeric repeat region; IDA:PomBase.
DR GO; GO:1990879; C:CST complex; IPI:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0000782; C:telomere cap complex; IDA:PomBase.
DR GO; GO:0043047; F:single-stranded telomeric DNA binding; ISO:PomBase.
DR GO; GO:0032211; P:negative regulation of telomere maintenance via telomerase; IMP:PomBase.
DR GO; GO:0016233; P:telomere capping; IMP:PomBase.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR018856; Stn1_N.
DR Pfam; PF10451; Stn1; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Chromosome; DNA-binding; Nucleus; Reference proteome;
KW Telomere.
FT CHAIN 1..325
FT /note="Protein stn1"
FT /id="PRO_0000312637"
FT DNA_BIND 50..126
FT /note="OB"
FT HELIX 23..26
FT /evidence="ECO:0007829|PDB:3KF6"
FT STRAND 40..42
FT /evidence="ECO:0007829|PDB:3KF6"
FT STRAND 45..47
FT /evidence="ECO:0007829|PDB:3KF6"
FT STRAND 49..62
FT /evidence="ECO:0007829|PDB:3KF6"
FT STRAND 65..71
FT /evidence="ECO:0007829|PDB:3KF6"
FT STRAND 73..75
FT /evidence="ECO:0007829|PDB:3KF6"
FT STRAND 77..83
FT /evidence="ECO:0007829|PDB:3KF6"
FT HELIX 84..86
FT /evidence="ECO:0007829|PDB:3KF6"
FT HELIX 88..94
FT /evidence="ECO:0007829|PDB:3KF6"
FT STRAND 102..110
FT /evidence="ECO:0007829|PDB:3KF6"
FT STRAND 112..115
FT /evidence="ECO:0007829|PDB:3KF6"
FT STRAND 117..126
FT /evidence="ECO:0007829|PDB:3KF6"
FT HELIX 131..153
FT /evidence="ECO:0007829|PDB:3KF6"
SQ SEQUENCE 325 AA; 37995 MW; 9664D09FC59ADE1B CRC64;
MLENENQLTH QFPTLSRWNP MFISDVHKIS FHPHLQRYIG FWMGFPIRWI QIVGYIAAID
IYEGKHVLTV DDCSGMVLRV VFIIQDDFSM SKRAISMSPG NVVCVFGKIN SFRSEVELIA
QSFEELRDPN DEWKAWQKRM RYKKNLTKIS KNHHSIIRTP KKSYFPKDHA KELLKCIRQM
CKLNVQAGFT IEELIIYLKA KELHLPLVHI FNVENEIVEN CDGNHILALN FSLQTLLQHG
RIVRKSNSVY MLVTSKDIIR FVIPLMASGL LEAHKVQSIV RDSNPMFITL PLSAIAKHIC
QFLLRTKGKW RQAKKYTWVR DNQFV
