ID   STN1_XENTR              Reviewed;         368 AA.
AC   Q6DJ48;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=CST complex subunit STN1 {ECO:0000250|UniProtKB:Q9H668};
DE   AltName: Full=Oligonucleotide/oligosaccharide-binding fold-containing protein 1;
DE   AltName: Full=Suppressor of cdc thirteen homolog;
GN   Name=stn1 {ECO:0000250|UniProtKB:Q9H668}; Synonyms=obfc1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the CST complex proposed to act as a specialized
CC       replication factor promoting DNA replication under conditions of
CC       replication stress or natural replication barriers such as the telomere
CC       duplex. The CST complex binds single-stranded DNA with high affinity in
CC       a sequence-independent manner, while isolated subunits bind DNA with
CC       low affinity by themselves. Initially the CST complex has been proposed
CC       to protect telomeres from DNA degradation. However, the CST complex has
CC       been shown to be involved in several aspects of telomere replication.
CC       {ECO:0000250|UniProtKB:Q9H668}.
CC   -!- SUBUNIT: Component of the CST complex. {ECO:0000250|UniProtKB:Q9H668}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H668}.
CC       Chromosome, telomere {ECO:0000250|UniProtKB:Q9H668}.
CC   -!- SIMILARITY: Belongs to the CTC1 family. {ECO:0000305}.
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DR   EMBL; BC075336; AAH75336.1; -; mRNA.
DR   RefSeq; NP_001004908.1; NM_001004908.1.
DR   AlphaFoldDB; Q6DJ48; -.
DR   SMR; Q6DJ48; -.
DR   STRING; 8364.ENSXETP00000063628; -.
DR   DNASU; 448268; -.
DR   GeneID; 448268; -.
DR   KEGG; xtr:448268; -.
DR   CTD; 79991; -.
DR   Xenbase; XB-GENE-988862; stn1.
DR   eggNOG; KOG3108; Eukaryota.
DR   InParanoid; Q6DJ48; -.
DR   OrthoDB; 1451022at2759; -.
DR   Reactome; R-XTR-174411; Polymerase switching on the C-strand of the telomere.
DR   Reactome; R-XTR-174430; Telomere C-strand synthesis initiation.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000011402; Expressed in skeletal muscle tissue and 12 other tissues.
DR   GO; GO:0000781; C:chromosome, telomeric region; ISS:UniProtKB.
DR   GO; GO:1990879; C:CST complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0043047; F:single-stranded telomeric DNA binding; ISS:UniProtKB.
DR   GO; GO:0016233; P:telomere capping; IEA:InterPro.
DR   GO; GO:0000723; P:telomere maintenance; ISS:UniProtKB.
DR   GO; GO:0010833; P:telomere maintenance via telomere lengthening; ISS:UniProtKB.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.10.980; -; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   InterPro; IPR015253; CST_STN1_C.
DR   InterPro; IPR042082; CST_Stn1_wHTH1_sf.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR040260; RFA2-like.
DR   InterPro; IPR014647; Stn1.
DR   InterPro; IPR018856; Stn1_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13989; PTHR13989; 1.
DR   Pfam; PF10451; Stn1; 1.
DR   Pfam; PF09170; STN1_2; 1.
DR   PIRSF; PIRSF036950; UCP036950; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; DNA-binding; Nucleus; Reference proteome; Telomere.
FT   CHAIN           1..368
FT                   /note="CST complex subunit STN1"
FT                   /id="PRO_0000392991"
FT   DNA_BIND        54..157
FT                   /note="OB"
FT   REGION          193..295
FT                   /note="Winged helix-turn-helix (wHTH) 1"
FT                   /evidence="ECO:0000250"
FT   REGION          296..368
FT                   /note="Winged helix-turn-helix (wHTH) 2"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   368 AA;  42243 MW;  8E239DFBDA9F410E CRC64;
     MQPASLEETP SLLWGLDPIF LAFAKLYIKD ILELKESQQV PGIFFYRGHP IKQVDVLGTV
     VFVREKENFY SYGVDDSTGV ISCTCWKSTA PTEVSSPGTS ARHVSSSSKD LDVMMRELYK
     EESKKAKLDI GDTIRVRGSI KVFRDQREIV ASVFYKVEDP KLDIQMARMF DLPYMYRNVY
     DKPFAIPEHL KDSSAGQTDH HIVTQSHLIM LLSEKVKVFL MENKIHNFYQ RELESVDSLI
     AIASRPVSDF KTIESMESSN SKQIRSIFKE AIQLLLKEGY IFQKDQNREV YQVTDQDKDL
     HKLTLNIIKE DCRRQKHAEK GCHFLHILTC VRLSVGSSVS EAVLRRVIDT LEGNSDIVST
     MENYYTAF