ID   STNB_CAEEL              Reviewed;        1693 AA.
AC   P90761; E1B6U3; E1B6U4; E1B6U5;
DT   15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   21-SEP-2011, sequence version 2.
DT   03-AUG-2022, entry version 153.
DE   RecName: Full=Putative stoned B-like protein;
DE   AltName: Full=Adaptin-related protein 10;
DE   AltName: Full=Uncoordinated protein 41;
GN   Name=unc-41; Synonyms=apt-10; ORFNames=C27H6.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   ASSIGNMENT OF APT-10 TO UNC-41.
RX   PubMed=11454451; DOI=10.1016/s0955-0674(00)00235-0;
RA   Robinson M.S., Bonifacino J.S.;
RT   "Adaptor-related proteins.";
RL   Curr. Opin. Cell Biol. 13:444-453(2001).
CC   -!- FUNCTION: Potential adapter protein, which may be involved in endocytic
CC       vesicle recycling of synaptic vesicles. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=a;
CC         IsoId=P90761-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=P90761-2; Sequence=VSP_041805;
CC       Name=c;
CC         IsoId=P90761-3; Sequence=VSP_041806;
CC   -!- DOMAIN: The Asp-Pro-Phe (DPF) motifs, which are found in many
CC       presynatic proteins, are thought to mediate an interaction with Alpha-
CC       adaptin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Stoned B family. {ECO:0000305}.
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DR   EMBL; Z81042; CBW48339.1; -; Genomic_DNA.
DR   EMBL; Z81042; CBW48340.1; -; Genomic_DNA.
DR   EMBL; Z81042; CBW48341.1; -; Genomic_DNA.
DR   PIR; T19536; T19536.
DR   RefSeq; NP_001256157.1; NM_001269228.1. [P90761-1]
DR   RefSeq; NP_001256158.1; NM_001269229.1. [P90761-2]
DR   RefSeq; NP_001256159.1; NM_001269230.1. [P90761-3]
DR   AlphaFoldDB; P90761; -.
DR   SMR; P90761; -.
DR   BioGRID; 44421; 1.
DR   STRING; 6239.C27H6.1a; -.
DR   EPD; P90761; -.
DR   PaxDb; P90761; -.
DR   PeptideAtlas; P90761; -.
DR   EnsemblMetazoa; C27H6.1a.1; C27H6.1a.1; WBGene00006777. [P90761-1]
DR   EnsemblMetazoa; C27H6.1b.1; C27H6.1b.1; WBGene00006777. [P90761-2]
DR   EnsemblMetazoa; C27H6.1c.1; C27H6.1c.1; WBGene00006777. [P90761-3]
DR   GeneID; 179387; -.
DR   KEGG; cel:CELE_C27H6.1; -.
DR   UCSC; C27H6.1; c. elegans. [P90761-1]
DR   CTD; 179387; -.
DR   WormBase; C27H6.1a; CE45344; WBGene00006777; unc-41. [P90761-1]
DR   WormBase; C27H6.1b; CE45373; WBGene00006777; unc-41. [P90761-2]
DR   WormBase; C27H6.1c; CE45298; WBGene00006777; unc-41. [P90761-3]
DR   eggNOG; KOG2677; Eukaryota.
DR   GeneTree; ENSGT00940000168142; -.
DR   HOGENOM; CLU_002975_0_0_1; -.
DR   InParanoid; P90761; -.
DR   OMA; CEGMDLE; -.
DR   OrthoDB; 118631at2759; -.
DR   Reactome; R-CEL-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-CEL-8856828; Clathrin-mediated endocytosis.
DR   PRO; PR:P90761; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00006777; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0030136; C:clathrin-coated vesicle; IBA:GO_Central.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IDA:WormBase.
DR   GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR   GO; GO:0035615; F:clathrin adaptor activity; IBA:GO_Central.
DR   GO; GO:0040017; P:positive regulation of locomotion; IMP:WormBase.
DR   GO; GO:0030100; P:regulation of endocytosis; IBA:GO_Central.
DR   GO; GO:0048488; P:synaptic vesicle endocytosis; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   InterPro; IPR036168; AP2_Mu_C_sf.
DR   InterPro; IPR028565; MHD.
DR   InterPro; IPR012320; SHD_dom.
DR   Pfam; PF00928; Adap_comp_sub; 1.
DR   SUPFAM; SSF49447; SSF49447; 1.
DR   PROSITE; PS51072; MHD; 1.
DR   PROSITE; PS51070; SHD; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Cytoplasm; Endocytosis; Reference proteome; Repeat.
FT   CHAIN           1..1693
FT                   /note="Putative stoned B-like protein"
FT                   /id="PRO_0000185734"
FT   DOMAIN          1136..1283
FT                   /note="SHD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00403"
FT   DOMAIN          1287..1606
FT                   /note="MHD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00404"
FT   REGION          1..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          222..322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          334..371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          383..438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          585..807
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          841..869
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          899..1024
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1062..1095
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1633..1693
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           684..686
FT                   /note="DPF 1"
FT   MOTIF           1006..1008
FT                   /note="DPF 2"
FT   MOTIF           1024..1026
FT                   /note="DPF 3"
FT   MOTIF           1039..1041
FT                   /note="DPF 4"
FT   COMPBIAS        1..18
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        19..40
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        271..322
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        389..411
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        419..433
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        594..616
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        632..658
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        664..681
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        694..722
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        743..761
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        762..781
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        786..804
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        899..917
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1069..1095
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1636..1653
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1660..1682
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..373
FT                   /note="Missing (in isoform c)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_041806"
FT   VAR_SEQ         1..282
FT                   /note="Missing (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_041805"
SQ   SEQUENCE   1693 AA;  189844 MW;  D40D67FDB67FFE84 CRC64;
     MSWRDRDFDP HGGRNAFRLT DESKQSSSER AASMRAMRSF TQSIEDEGPP ELPASLDIDM
     IEGVSMKTSD TNDTIIEVKP GKVDPQLGET QKYKMAVPGP GHSEQEQELH KSLIRDEEED
     AEVEQVFAAS AEPVVTPPKS LNFAETAEEL RHAYDQKIRK RPTTPTSACV LDGIAFFAGS
     VDGSNDTIPT DAEKKIKVSI PSGRRRKTEN MSYSEFYESM ANQIPGGGGR RMSQSGRTTP
     LHDYEGDILD ENPQYKDKAP PAPVVHRRSS IEWENFADME DKMEQAEEKA RKEEKKEKEE
     TAEVAQNDDV TTEKHQNEVE KSKKMLNFLA KPPTVEITSP DAPHQGAFHD NTPKEPKVVE
     EEEDDDLPTF SEDMDEARQQ VMKEMTESVV KTENVENEKQ EDTHISEGHV EYGTEESPAV
     TDGSYQQDGT ENAYDPNAYP GYIWNYETQE WEYDPSYVAP EEPIDQSAYE AQAAAYAEVD
     QRAAEVVYQR EHAGYDQGDF YTHQDTSYSS EAYAHDQAKG YQDPNAYGAE AAADNSQEYD
     YSAYGGYEGY LAACRAYDEE SQQPQYGETV ATEAYSQDYG YEQQGDYHHE GVGATDENST
     SAISGYEQNG ASTSLGYGDA QGYDGYDHNA SYYQGQEYQQ EYYQNHKYEN SQYQVDQHPA
     ESAAPPRPVA PMEPLFKQAP PQPDPFGWDS SGHTGDAPTA SEPVQELSPT PEASSSTGTS
     APARPPPARP EAPKKDETAV DAAAPPRPPP AARPPPPRPA PANKEKPKEP EPEEDAWAQF
     KRMTEKVSTA VKSTESTLKN LEETSAANDI KDESYLANVG GSQGFVNEST QKEIQRLTEE
     KKMEKLQKKK LKQQGKKAAT PTLEPDEEDA MDRAAQELAM KMASMRSDMA DWKAPEMIPV
     KEIKKAPEIR RVDSASAIPP RKRSSIKDVQ QDSGGSLELP PHLAAPQDSI APNPKGDHAP
     DDPILSAPAW ADFETSEPML PPSESGFFSN KDASNEGGVS RDATDDPFVT TVASSEKRSS
     FVADPFAPQQ AALIDESYDP FAVVAVEEVV AMAKAKAEQA AANAENEDDF YNGRQSPTLS
     TPTPEGGSPI SQQRPNAFED DFKCAELTGL DTPTPLYDED DSQPLTDFIP KFDGDGWDLM
     VRHPIKKKSF MAERCWKPCY VRLHGLTLYL YNDKKDAQPI QELLLQATYS LSDTTLQAYD
     VYGKIHTVKL QFVVYKEKVG IRPGQISRLV DGHITKYGLP LEHSAQCTVL LKFGSLNASH
     LQTFVTTVED LLFKCKITRT AKPVYKQDEV QIHCYDEYSA FVDKEGILSD QKARVRLFCL
     AFLTGSPVLE VGLNDRRRQG KEIVRRKDIL PMYTERWIRF EALEFHSIVN KPEFDKEQVI
     AFSPPDGCFF EIMRFRVRPP RNREKAMTVK SIMKIAGSKV EIRIEAMAAA QIQRTRGSDE
     RRNIPCEDIA IRFPIPEAWI YLFREERHWG VGSIHSKKLR PGKVKNLKDR LLGAVQASEP
     NLIECAIGEA KYEHVYRSLV WRIPRLPEKH HAAYKSHLLK CRFELSSFDL MPEEFLPRCD
     VDFTMPLATV SNTVVRSVSV EQHEDSDRVE KFVRYVAKYQ YKVEIDYVQC ADLDLDMADP
     SVNPEAAAAP VPELHQPTFN PSTQESDTQQ GYRIDFNEAE MGGSNRRDDS SSDEEPDSHK
     MPIIQIDMKN YGY