STO2_CAEEL
ID STO2_CAEEL Reviewed; 375 AA.
AC Q19958; D5MCN3; D5MCN4; D5MCN5; D5MCN6;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 4.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Stomatin-2;
GN Name=sto-2; ORFNames=F32A6.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION.
RX PubMed=15916950; DOI=10.1016/j.cub.2005.04.059;
RA Blacque O.E., Perens E.A., Boroevich K.A., Inglis P.N., Li C., Warner A.,
RA Khattra J., Holt R.A., Ou G., Mah A.K., McKay S.J., Huang P., Swoboda P.,
RA Jones S.J.M., Marra M.A., Baillie D.L., Moerman D.G., Shaham S.,
RA Leroux M.R.;
RT "Functional genomics of the cilium, a sensory organelle.";
RL Curr. Biol. 15:935-941(2005).
CC -!- FUNCTION: May be involved in cilia-related function.
CC {ECO:0000269|PubMed:15916950}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=c;
CC IsoId=Q19958-1; Sequence=Displayed;
CC Name=a;
CC IsoId=Q19958-2; Sequence=VSP_039799;
CC Name=b;
CC IsoId=Q19958-3; Sequence=VSP_039801, VSP_039802;
CC Name=d;
CC IsoId=Q19958-4; Sequence=VSP_039800, VSP_039803;
CC -!- SIMILARITY: Belongs to the band 7/mec-2 family. {ECO:0000305}.
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DR EMBL; FO080679; CCD65719.1; -; Genomic_DNA.
DR EMBL; FO080679; CCD65720.1; -; Genomic_DNA.
DR EMBL; FO080679; CCD65722.1; -; Genomic_DNA.
DR EMBL; FO080679; CCD65723.1; -; Genomic_DNA.
DR PIR; T16240; T16240.
DR RefSeq; NP_001257020.1; NM_001270091.1. [Q19958-3]
DR RefSeq; NP_001257021.1; NM_001270092.1. [Q19958-1]
DR RefSeq; NP_001257022.1; NM_001270093.1. [Q19958-4]
DR RefSeq; NP_001257023.1; NM_001270094.1. [Q19958-2]
DR AlphaFoldDB; Q19958; -.
DR SMR; Q19958; -.
DR BioGRID; 45736; 1.
DR STRING; 6239.F32A6.5c; -.
DR iPTMnet; Q19958; -.
DR EPD; Q19958; -.
DR PaxDb; Q19958; -.
DR PeptideAtlas; Q19958; -.
DR PRIDE; Q19958; -.
DR EnsemblMetazoa; F32A6.5a.1; F32A6.5a.1; WBGene00006064. [Q19958-2]
DR EnsemblMetazoa; F32A6.5b.1; F32A6.5b.1; WBGene00006064. [Q19958-3]
DR EnsemblMetazoa; F32A6.5c.1; F32A6.5c.1; WBGene00006064. [Q19958-1]
DR EnsemblMetazoa; F32A6.5d.1; F32A6.5d.1; WBGene00006064. [Q19958-4]
DR GeneID; 180802; -.
DR KEGG; cel:CELE_F32A6.5; -.
DR UCSC; F32A6.5; c. elegans. [Q19958-1]
DR CTD; 180802; -.
DR WormBase; F32A6.5a; CE43778; WBGene00006064; sto-2. [Q19958-2]
DR WormBase; F32A6.5b; CE44788; WBGene00006064; sto-2. [Q19958-3]
DR WormBase; F32A6.5c; CE44738; WBGene00006064; sto-2. [Q19958-1]
DR WormBase; F32A6.5d; CE44767; WBGene00006064; sto-2. [Q19958-4]
DR eggNOG; KOG2621; Eukaryota.
DR GeneTree; ENSGT01030000234614; -.
DR InParanoid; Q19958; -.
DR OMA; KFGRFER; -.
DR OrthoDB; 1062075at2759; -.
DR PhylomeDB; Q19958; -.
DR Reactome; R-CEL-2672351; Stimuli-sensing channels.
DR Reactome; R-CEL-6798695; Neutrophil degranulation.
DR Reactome; R-CEL-8980692; RHOA GTPase cycle.
DR Reactome; R-CEL-9013026; RHOB GTPase cycle.
DR Reactome; R-CEL-9013106; RHOC GTPase cycle.
DR Reactome; R-CEL-9013407; RHOH GTPase cycle.
DR PRO; PR:Q19958; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00006064; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR Gene3D; 3.30.479.30; -; 1.
DR InterPro; IPR043202; Band-7_stomatin-like.
DR InterPro; IPR001107; Band_7.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR018080; Band_7/stomatin-like_CS.
DR InterPro; IPR001972; Stomatin_HflK_HflKC_fam.
DR PANTHER; PTHR10264; PTHR10264; 1.
DR Pfam; PF01145; Band_7; 1.
DR PRINTS; PR00721; STOMATIN.
DR SMART; SM00244; PHB; 1.
DR SUPFAM; SSF117892; SSF117892; 1.
DR PROSITE; PS01270; BAND_7; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..375
FT /note="Stomatin-2"
FT /id="PRO_0000094040"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..55
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_039799"
FT VAR_SEQ 1..28
FT /note="Missing (in isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_039800"
FT VAR_SEQ 1..17
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_039801"
FT VAR_SEQ 18..40
FT /note="GNSGNSGNRRASSTRISFSDQLD -> MSKSEGSRKVKLRFAASGVSSSN
FT (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_039802"
FT VAR_SEQ 29..40
FT /note="SSTRISFSDQLD -> MEFLEVRQGSPN (in isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_039803"
SQ SEQUENCE 375 AA; 41370 MW; FF639947DB9D3AD7 CRC64;
MKTQPSEESA SPAPVNPGNS GNSGNRRASS TRISFSDQLD GGDSGDSSSN ESERLMESDD
EGNIQIPVPT GQPRGRMGRR FTLNPLIFAK EEREARRQSL AQLKLSYYPK HMNPEHYDTG
LGFCGWFLMG LSWIMVISTF PVSIYFCMKV VQEYERAVIF RLGRLIGGGA KGPGIFFVLP
CIESYTKVDL RTVSFSVPPQ EILTKDSVTT SVDAVIYYRI SNATVSVANV ENAHHSTRLL
AQTTLRNMLG TRSLSEILSD RETLAASMQT ILDEATESWG IKVERVEIKD VRLPIQLQRA
MAAEAEATRE ARAKVIAAEG EQKASRALRD AASVIAQSPA ALQLRYLQTL NSVAAEKNST
IIFPLPMELV RHLIN
