STOX1_MOUSE
ID STOX1_MOUSE Reviewed; 990 AA.
AC B2RQL2; Q3UZS9;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Storkhead-box protein 1 {ECO:0000312|MGI:MGI:2684909};
GN Name=Stox1 {ECO:0000312|MGI:MGI:2684909};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|Proteomes:UP000000589};
RN [1] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000312|EMBL:AAI37979.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3] {ECO:0000312|EMBL:BAE21776.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 462-990.
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAE21776.1};
RC TISSUE=Pituitary {ECO:0000312|EMBL:BAE21776.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=25677106; DOI=10.1111/cpr.12174;
RA Nie X., Zhang K., Wang L., Ou G., Zhu H., Gao W.Q.;
RT "Transcription factor STOX1 regulates proliferation of inner ear epithelial
RT cells via the AKT pathway.";
RL Cell Prolif. 48:209-220(2015).
CC -!- FUNCTION: Involved in regulating the levels of reactive oxidative
CC species and reactive nitrogen species and in mitochondrial homeostasis
CC in the placenta (By similarity). Required for regulation of inner ear
CC epithelial cell proliferation via the AKT signaling pathway
CC (PubMed:25677106). Involved in cell cycle regulation by binding to the
CC CCNB1 promoter, up-regulating its expression and promoting mitotic
CC entry (By similarity). Induces phosphorylation of MAPT/tau (By
CC similarity). {ECO:0000250|UniProtKB:Q6ZVD7,
CC ECO:0000269|PubMed:25677106}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25677106}. Cytoplasm
CC {ECO:0000269|PubMed:25677106}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000250|UniProtKB:Q6ZVD7}. Note=In
CC epithelial cells, diffusely expressed in the cytoplasm, particularly in
CC peri-membrane cortical regions (PubMed:25677106). Concentrated at
CC centrosomes during metaphase (By similarity).
CC {ECO:0000250|UniProtKB:Q6ZVD7, ECO:0000269|PubMed:25677106}.
CC -!- TISSUE SPECIFICITY: Detected in sensory epithelial cells of the inner
CC ear but not in adjacent surrounding tissue (at protein level).
CC {ECO:0000269|PubMed:25677106}.
CC -!- DEVELOPMENTAL STAGE: Highly expressed at 14 dpc with lower levels at 18
CC dpc and P3. {ECO:0000269|PubMed:25677106}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE21776.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC122539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137978; AAI37979.1; -; mRNA.
DR EMBL; AK133671; BAE21776.1; ALT_INIT; mRNA.
DR CCDS; CCDS48580.1; -.
DR RefSeq; NP_001028432.1; NM_001033260.1.
DR AlphaFoldDB; B2RQL2; -.
DR SMR; B2RQL2; -.
DR STRING; 10090.ENSMUSP00000114652; -.
DR iPTMnet; B2RQL2; -.
DR PhosphoSitePlus; B2RQL2; -.
DR PaxDb; B2RQL2; -.
DR PRIDE; B2RQL2; -.
DR ProteomicsDB; 257460; -.
DR Antibodypedia; 51097; 76 antibodies from 20 providers.
DR Ensembl; ENSMUST00000133371; ENSMUSP00000114652; ENSMUSG00000036923.
DR GeneID; 216021; -.
DR KEGG; mmu:216021; -.
DR UCSC; uc011xfe.1; mouse.
DR CTD; 219736; -.
DR MGI; MGI:2684909; Stox1.
DR VEuPathDB; HostDB:ENSMUSG00000036923; -.
DR eggNOG; KOG3897; Eukaryota.
DR GeneTree; ENSGT00520000055589; -.
DR HOGENOM; CLU_306723_0_0_1; -.
DR InParanoid; B2RQL2; -.
DR OMA; DQLVKHY; -.
DR OrthoDB; 494782at2759; -.
DR PhylomeDB; B2RQL2; -.
DR TreeFam; TF337253; -.
DR BioGRID-ORCS; 216021; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Stox1; mouse.
DR PRO; PR:B2RQL2; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; B2RQL2; protein.
DR Bgee; ENSMUSG00000036923; Expressed in spermatocyte and 75 other tissues.
DR ExpressionAtlas; B2RQL2; baseline and differential.
DR Genevisible; B2RQL2; MM.
DR GO; GO:0005938; C:cell cortex; IDA:UniProtKB.
DR GO; GO:0005813; C:centrosome; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0001650; C:fibrillar center; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0071500; P:cellular response to nitrosative stress; ISO:MGI.
DR GO; GO:0048839; P:inner ear development; IDA:UniProtKB.
DR GO; GO:0010629; P:negative regulation of gene expression; ISO:MGI.
DR GO; GO:0045787; P:positive regulation of cell cycle; IMP:UniProtKB.
DR GO; GO:1904031; P:positive regulation of cyclin-dependent protein kinase activity; ISO:MGI.
DR GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; ISO:MGI.
DR GO; GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; ISO:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
DR GO; GO:1904120; P:positive regulation of otic vesicle morphogenesis; IMP:UniProtKB.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISO:MGI.
DR GO; GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; ISO:MGI.
DR GO; GO:0051897; P:positive regulation of protein kinase B signaling; IMP:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; ISO:MGI.
DR GO; GO:1901858; P:regulation of mitochondrial DNA metabolic process; ISO:MGI.
DR GO; GO:0051881; P:regulation of mitochondrial membrane potential; ISO:MGI.
DR GO; GO:0010821; P:regulation of mitochondrion organization; ISO:MGI.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IMP:UniProtKB.
DR GO; GO:1902882; P:regulation of response to oxidative stress; ISO:MGI.
DR GO; GO:0061418; P:regulation of transcription from RNA polymerase II promoter in response to hypoxia; ISO:MGI.
DR InterPro; IPR019391; Storkhead-box_winged-helix.
DR InterPro; IPR040126; STOX1/2.
DR PANTHER; PTHR22437; PTHR22437; 1.
DR Pfam; PF10264; Stork_head; 1.
PE 1: Evidence at protein level;
KW Activator; Cell cycle; Cell division; Cytoplasm; Cytoskeleton; DNA-binding;
KW Mitosis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..990
FT /note="Storkhead-box protein 1"
FT /evidence="ECO:0000305"
FT /id="PRO_0000433298"
FT REGION 396..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 712..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..428
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..831
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 990 AA; 108902 MW; E57F3D1B188F7A23 CRC64;
MARPVQLAPG SLALVLSPRE AGQAAGEPGG RALFRAFRRA NARCFWNARL ARAASRLAFL
GWLRRGVLLV RAPQPCVQVL RDAWRRRALR PPRGFRITAV GDVFPVQMSP IAQCRFVPLA
EVLCCAIADM NAAQVMVTQQ SLLEHLIKHY PGIAVPSPDI LYSTLGALIQ ERKIYHTGEG
YFIVTPSTYF ITNTPMQGNK SALLSNEGCS GPTSGTYLVS VDCCAEPTQE NEALFSHCPS
CQCYPDTSMC DSKDLLTAAE VTRKSQEGLE ETTALTENQV VSASEDTHIC VNPKPLPYTK
DKGKRFGFGF LWRSLSRKEK PKAEYHSFSA QFPPEEWPVR DEDSSTKIPR DVEHALIKRI
NPVLTVDNLT KHTALMQKYE EQKKYNSQGT SMDILTTRHK DSSKEVIGKR QGQFAKSRRR
GSSHKGRHKA RSQGSELEPG NPGQEKEKQP KVPAAQPAPR TKSPSEQVHH LQGRNPAVLG
SHLIYKKQIN NPFQGMHLRK HSVSKGHAVQ KTHGLKPTCV GPEEKPFWSA GSSDPSGVFD
GEAQPPYPEQ CRDKLEAGST QVAKAPVHPV SDDFRGGPGN YPPRRVLPGP SRCCSFRESM
LRPGVYHEEN KDLPEVLRKS WSTCDMFLGT KEKKQALPAQ RCSLDPDSSS VHAEDKTVDK
ILHQFQNLGL LDCPAGANRL RTHERQDGNS EELSRKALQI PEAEIVNMEN EGLSDSEQDQ
VALSHSDPGA GDDGGCSSLC LEDDDFSETD DFCPSLPGHT QHSFAGGGTW NHLGTPAMTG
KSLTDCNSKA HRLELLAIER NPWYKATGLF SNAGESPNPD LSDNPGQNSR IPWGFNYEGE
PTVAHVQTPA AAAGRSLLAC STVRTTSFPV EILQESPGDR GKSPIVWRQS LPSQEMKEHF
TDKLQLVKTS HGPVSAQEPQ GEHLEGTENY SMTGDSGIDS PRTQSLVSTN SAILDGFKRR
QHFLPNREGV QKSQNLASNS LFQLTPAINV
