STOX2_HUMAN
ID STOX2_HUMAN Reviewed; 926 AA.
AC Q9P2F5; A6H8U4; Q9NPS8;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Storkhead-box protein 2;
GN Name=STOX2; Synonyms=KIAA1392;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=10718198; DOI=10.1093/dnares/7.1.65;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVI. The
RT complete sequences of 150 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:65-73(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 646-863 (ISOFORM 2).
RC TISSUE=Melanoma;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9P2F5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9P2F5-2; Sequence=VSP_030072, VSP_030073;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA92630.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB037813; BAA92630.1; ALT_INIT; mRNA.
DR EMBL; AK289840; BAF82529.1; -; mRNA.
DR EMBL; CH471056; EAX04684.1; -; Genomic_DNA.
DR EMBL; BC146754; AAI46755.1; -; mRNA.
DR EMBL; AL390216; CAB99230.1; -; mRNA.
DR CCDS; CCDS47167.1; -. [Q9P2F5-1]
DR PIR; T51887; T51887.
DR RefSeq; NP_064610.1; NM_020225.2. [Q9P2F5-1]
DR AlphaFoldDB; Q9P2F5; -.
DR BioGRID; 121295; 9.
DR IntAct; Q9P2F5; 5.
DR STRING; 9606.ENSP00000311257; -.
DR GlyGen; Q9P2F5; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9P2F5; -.
DR PhosphoSitePlus; Q9P2F5; -.
DR BioMuta; STOX2; -.
DR DMDM; 166223490; -.
DR EPD; Q9P2F5; -.
DR jPOST; Q9P2F5; -.
DR MassIVE; Q9P2F5; -.
DR MaxQB; Q9P2F5; -.
DR PaxDb; Q9P2F5; -.
DR PeptideAtlas; Q9P2F5; -.
DR PRIDE; Q9P2F5; -.
DR ProteomicsDB; 83801; -. [Q9P2F5-1]
DR ProteomicsDB; 83802; -. [Q9P2F5-2]
DR Antibodypedia; 56777; 61 antibodies from 22 providers.
DR DNASU; 56977; -.
DR Ensembl; ENST00000308497.9; ENSP00000311257.4; ENSG00000173320.12. [Q9P2F5-1]
DR GeneID; 56977; -.
DR KEGG; hsa:56977; -.
DR MANE-Select; ENST00000308497.9; ENSP00000311257.4; NM_020225.3; NP_064610.1.
DR UCSC; uc003ivz.2; human. [Q9P2F5-1]
DR CTD; 56977; -.
DR DisGeNET; 56977; -.
DR GeneCards; STOX2; -.
DR HGNC; HGNC:25450; STOX2.
DR HPA; ENSG00000173320; Low tissue specificity.
DR MIM; 617359; gene.
DR neXtProt; NX_Q9P2F5; -.
DR OpenTargets; ENSG00000173320; -.
DR PharmGKB; PA142670861; -.
DR VEuPathDB; HostDB:ENSG00000173320; -.
DR eggNOG; KOG3897; Eukaryota.
DR GeneTree; ENSGT00520000055589; -.
DR HOGENOM; CLU_013650_0_0_1; -.
DR InParanoid; Q9P2F5; -.
DR OMA; TSGCIRD; -.
DR OrthoDB; 494782at2759; -.
DR PhylomeDB; Q9P2F5; -.
DR TreeFam; TF331863; -.
DR PathwayCommons; Q9P2F5; -.
DR SignaLink; Q9P2F5; -.
DR BioGRID-ORCS; 56977; 8 hits in 1056 CRISPR screens.
DR ChiTaRS; STOX2; human.
DR GenomeRNAi; 56977; -.
DR Pharos; Q9P2F5; Tbio.
DR PRO; PR:Q9P2F5; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q9P2F5; protein.
DR Bgee; ENSG00000173320; Expressed in Brodmann (1909) area 23 and 184 other tissues.
DR ExpressionAtlas; Q9P2F5; baseline and differential.
DR Genevisible; Q9P2F5; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IEP:UniProtKB.
DR GO; GO:0001893; P:maternal placenta development; IEP:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR019391; Storkhead-box_winged-helix.
DR InterPro; IPR040126; STOX1/2.
DR PANTHER; PTHR22437; PTHR22437; 1.
DR Pfam; PF10264; Stork_head; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..926
FT /note="Storkhead-box protein 2"
FT /id="PRO_0000313629"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 724..803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 825..926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..32
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..374
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..391
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..495
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..803
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 826..884
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..926
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 863
FT /note="T -> N (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_030072"
FT VAR_SEQ 864..926
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_030073"
SQ SEQUENCE 926 AA; 102671 MW; C387E93B35EC7A57 CRC64;
MKKTRSTTLR RAWPSSDFSD RASDRMRSRS EKDYRLHKRF PAAFAPQASR GYMTSGDVSP
ISMSPISQSQ FIPLGEILCL AISAMNSARK PVTQEALMEH LTTCFPGVPT PSQEILRHTL
NTLVRERKIY PTPDGYFIVT PQTYFITPSL IRTNSKWYHL DERIPDRSQC TSPQPGTITP
SASGCVRERT LPRNHCDSCH CCREDVHSTH APTLQRKSAK DCKDPYCPPS LCQVPPTEKS
KSTVNFSYKT ETLSKPKDSE KQSKKFGLKL FRLSFKKDKT KQLANFSAQF PPEEWPLRDE
DTPATIPREV EMEIIRRINP DLTVENVMRH TALMKKLEEE KAQRSKAGSS AHHSGRSKKS
RTHRKSHGKS RSHSKTRVSK GDPSDGSHLD IPAEREYDFC DPLTRVPREG CFIIEHKGDN
FIMHSNTNVL ESHFPMTPEW DVSGELAKRR TEMPFPEPSR GSSHSKVHRS HSHTQDRRSR
NERSNKAKER SRSMDNSKGP LGASSLGTPE DLAEGCSQDD QTPSQSYIDD STLRPAQTVS
LQRAHISSTS YKEVCIPEIV SGSKEPSSAC SLLEPGKPPE SLPSYGELNS CPTKTATDDY
FQCNTSSETV LTAPSPLGKN KEDHDTLTLA EGVKKLSPSD RQVPHSSREP VGHKEESPKG
PGGGPAASGG VAEGIANGRL VQHHGAEPSS LDKRKEIFSK DTLFKPLHST LSVNSYHKSS
LSLLKSHPKT PADTLPGRCE KLEPSLGTSA AQAMPASQRQ QESGGNQEAS FDYYNVSDDD
DSEEGANKNT EEEKNREDVG TMQWLLEREK ERDLQRKFEK NLTLLAPKET DSSSNQRATH
SARLDSMDSS SITVDSGFNS PRTRESLASN TSSIVESNRR QNPALSPAHG GAGPAFNFRA
SAEPPTNEAE KLQKPSNCLQ ASVTSV
