STOX2_MOUSE
ID STOX2_MOUSE Reviewed; 926 AA.
AC Q499E5; B2RR59; Q3TRF0; Q497F9; Q6ZPS3; Q8CDI1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Storkhead-box protein 2;
GN Name=Stox2; Synonyms=Kiaa1392;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Embryonic tail;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Hypothalamus, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=CD-1; TISSUE=Brain, and Neural stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q499E5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q499E5-2; Sequence=VSP_030075, VSP_030076;
CC Name=3;
CC IsoId=Q499E5-3; Sequence=VSP_030074, VSP_030075, VSP_030076;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC98156.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK129346; BAC98156.1; ALT_INIT; mRNA.
DR EMBL; AK030015; BAC26735.1; -; mRNA.
DR EMBL; AK162847; BAE37080.1; -; mRNA.
DR EMBL; BC099949; AAH99949.1; -; mRNA.
DR EMBL; BC100572; AAI00573.1; -; mRNA.
DR EMBL; BC100573; AAI00574.1; -; mRNA.
DR EMBL; BC138237; AAI38238.1; -; mRNA.
DR EMBL; BC138238; AAI38239.1; -; mRNA.
DR CCDS; CCDS40336.1; -. [Q499E5-3]
DR CCDS; CCDS52548.1; -. [Q499E5-1]
DR CCDS; CCDS85535.1; -. [Q499E5-2]
DR RefSeq; NP_001107783.1; NM_001114311.1. [Q499E5-1]
DR RefSeq; NP_001273305.1; NM_001286376.1. [Q499E5-2]
DR RefSeq; NP_780371.3; NM_175162.4. [Q499E5-3]
DR RefSeq; XP_011240539.1; XM_011242237.2. [Q499E5-3]
DR AlphaFoldDB; Q499E5; -.
DR BioGRID; 214451; 5.
DR IntAct; Q499E5; 1.
DR STRING; 10090.ENSMUSP00000078190; -.
DR iPTMnet; Q499E5; -.
DR PhosphoSitePlus; Q499E5; -.
DR MaxQB; Q499E5; -.
DR PaxDb; Q499E5; -.
DR PRIDE; Q499E5; -.
DR ProteomicsDB; 258643; -. [Q499E5-1]
DR ProteomicsDB; 258644; -. [Q499E5-2]
DR ProteomicsDB; 258645; -. [Q499E5-3]
DR Antibodypedia; 56777; 61 antibodies from 22 providers.
DR DNASU; 71069; -.
DR Ensembl; ENSMUST00000079195; ENSMUSP00000078190; ENSMUSG00000038143. [Q499E5-1]
DR Ensembl; ENSMUST00000110367; ENSMUSP00000105996; ENSMUSG00000038143. [Q499E5-3]
DR Ensembl; ENSMUST00000210030; ENSMUSP00000147281; ENSMUSG00000038143. [Q499E5-3]
DR Ensembl; ENSMUST00000211737; ENSMUSP00000147477; ENSMUSG00000038143. [Q499E5-2]
DR GeneID; 71069; -.
DR KEGG; mmu:71069; -.
DR UCSC; uc009lqv.2; mouse. [Q499E5-3]
DR UCSC; uc009lqw.2; mouse. [Q499E5-2]
DR UCSC; uc009lqx.2; mouse. [Q499E5-1]
DR CTD; 56977; -.
DR MGI; MGI:1918319; Stox2.
DR VEuPathDB; HostDB:ENSMUSG00000038143; -.
DR eggNOG; KOG3897; Eukaryota.
DR GeneTree; ENSGT00520000055589; -.
DR HOGENOM; CLU_013650_0_0_1; -.
DR InParanoid; Q499E5; -.
DR OMA; SGCIRER; -.
DR OrthoDB; 494782at2759; -.
DR PhylomeDB; Q499E5; -.
DR TreeFam; TF331863; -.
DR BioGRID-ORCS; 71069; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Stox2; mouse.
DR PRO; PR:Q499E5; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q499E5; protein.
DR Bgee; ENSMUSG00000038143; Expressed in rostral migratory stream and 221 other tissues.
DR ExpressionAtlas; Q499E5; baseline and differential.
DR Genevisible; Q499E5; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; ISS:UniProtKB.
DR GO; GO:0001893; P:maternal placenta development; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0009617; P:response to bacterium; IEP:MGI.
DR InterPro; IPR019391; Storkhead-box_winged-helix.
DR InterPro; IPR040126; STOX1/2.
DR PANTHER; PTHR22437; PTHR22437; 1.
DR Pfam; PF10264; Stork_head; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..926
FT /note="Storkhead-box protein 2"
FT /id="PRO_0000313631"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 723..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 823..926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..32
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..374
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..495
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 515..529
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..802
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..884
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 899..926
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..62
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_030074"
FT VAR_SEQ 863
FT /note="T -> N (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14621295,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:16141072"
FT /id="VSP_030075"
FT VAR_SEQ 864..926
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14621295,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:16141072"
FT /id="VSP_030076"
FT CONFLICT 122
FT /note="T -> A (in Ref. 3; AAH99949)"
FT /evidence="ECO:0000305"
FT CONFLICT 167
FT /note="R -> G (in Ref. 3; AAI00573/AAI00574)"
FT /evidence="ECO:0000305"
FT CONFLICT 235
FT /note="P -> T (in Ref. 2; BAC26735)"
FT /evidence="ECO:0000305"
FT CONFLICT 526
FT /note="S -> L (in Ref. 3; AAH99949)"
FT /evidence="ECO:0000305"
FT CONFLICT 671
FT /note="V -> A (in Ref. 3; AAI00573/AAI00574)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 926 AA; 102757 MW; 7560AC720C798D96 CRC64;
MKKTRSTTLR RAWPSSDFSD RASDRMRSRS EKDYRLHKRF PAAFAPQASR GYMTSGDVSP
ISMSPISQSQ FIPLGEILCL AISAMNSARK PVTQEALMEH LTTCFPGVPT PSQEILRHTL
NTLVRERKIY PTPDGYFIVT PQTYFITPSL IRTNSKWYHL DERVPDRSQC TSPQPGTITP
SASGCVRERT LPRKHCDSCH CCREDVHSMH ASTLQRKSAK DCKDPYCPPP LCQVPPTEKS
KSTINFSYKT ETLSKPKDGE KQSKKFGLKL FRLSFKKDKT KQLANFSAQF PPEEWPLRDE
DTPTTIPREV EMEIIRRINP DLTVENVMRH TALMKKLEEE KAHRSKAGSS AHHSGRSKKS
RTHRKSHGKS RSHSKTRVSK GDPSDGSHLD IPGEREYEFC DPLTRAPREG CFIIEHKGDN
FIMHSNTNVI ESHFPMTPEW DVSGELAKRR TEMPFPEPSR GSSHSKVHRS HSHTQDRRSR
NERSNKAKER SRSMDNSKGP LGASSLGTPE DLAEGCSQDD QTPSQSYIDD STLRPAQTIG
HQRAHIPSAS YKEVCIPEIV GGSKEPSSAC SLLEPGKTPE SMPSYGELSP CPAKTAVDDY
FQCNTSSETV LTAPSPLGKN KEDHDTLTLV EGVKKLSPSE RQTPHSSREP VGHKEESPKG
PGGGPAASGG VAEGLANGRL VQHHSAEPSS LDKRKEIFSK DTLFKPLHST LSVNSYHKSS
LSLLKSHPKS PVDTLPGRCE KLEPSLGTSA AQAMPPSQRQ QEPGGNQEAS FDYYNVSDDD
DSEEGANKNA EEEKNRDDVG TMQWLLEREK ERDLQRKFEK NLTLLTPKET DSSSNQRATH
SARLDSMDSS SITVDSGFNS PRTRESLASN TSSIVESNRR QNPALSPAHG GAGPTFNFRA
STDPPTSEAE KLQKPSNCLQ ASVTSV
