STP11_ARATH
ID STP11_ARATH Reviewed; 514 AA.
AC Q9FMX3; O81708;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Sugar transport protein 11;
DE AltName: Full=Hexose transporter 11;
GN Name=STP11; OrderedLocusNames=At5g23270; ORFNames=MKD15.13;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ACTIVITY REGULATION,
RP BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Flower;
RX PubMed=15565288; DOI=10.1007/s00425-004-1420-5;
RA Schneidereit A., Scholz-Starke J., Sauer N., Buettner M.;
RT "AtSTP11, a pollen tube-specific monosaccharide transporter in
RT Arabidopsis.";
RL Planta 221:48-55(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9501997; DOI=10.1093/dnares/4.6.401;
RA Nakamura Y., Sato S., Kaneko T., Kotani H., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence
RT features of the regions of 1,191,918 bp covered by seventeen physically
RT assigned P1 clones.";
RL DNA Res. 4:401-414(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 408-475.
RC STRAIN=cv. C24;
RA Baier K., Truernit E., Sauer N.;
RL Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY.
RX PubMed=16923188; DOI=10.1186/1471-2148-6-64;
RA Johnson D.A., Hill J.P., Thomas M.A.;
RT "The monosaccharide transporter gene family in land plants is ancient and
RT shows differential subfamily expression and expansion across lineages.";
RL BMC Evol. Biol. 6:64-64(2006).
CC -!- FUNCTION: Mediates an active uptake of hexoses, probably by
CC sugar/hydrogen symport. Can transport glucose, galactose, mannose,
CC xylose and 3-O-methylglucose, but not fructose and ribose.
CC {ECO:0000269|PubMed:15565288}.
CC -!- ACTIVITY REGULATION: Inhibited by uncouplers such as 2,4-dinitrophenol
CC and carbonyl cyanide-m-chlorophenyl-hydrazone.
CC {ECO:0000269|PubMed:15565288}.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC Kinetic parameters:
CC KM=25 uM for glucose (at pH 5.5) {ECO:0000269|PubMed:15565288};
CC pH dependence:
CC Optimum pH is 5.5. {ECO:0000269|PubMed:15565288};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15565288};
CC Multi-pass membrane protein {ECO:0000269|PubMed:15565288}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in germinating pollen and
CC pollen tube (at protein level). {ECO:0000269|PubMed:15565288}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; AJ344339; CAC69075.1; -; mRNA.
DR EMBL; AB007648; BAB11182.1; -; Genomic_DNA.
DR EMBL; CP002688; AED93146.1; -; Genomic_DNA.
DR EMBL; AK175890; BAD43653.1; -; mRNA.
DR EMBL; AJ001664; CAA04909.1; -; Genomic_DNA.
DR RefSeq; NP_197718.1; NM_122233.4.
DR AlphaFoldDB; Q9FMX3; -.
DR SMR; Q9FMX3; -.
DR STRING; 3702.AT5G23270.1; -.
DR TCDB; 2.A.1.1.61; the major facilitator superfamily (mfs).
DR PaxDb; Q9FMX3; -.
DR PRIDE; Q9FMX3; -.
DR EnsemblPlants; AT5G23270.1; AT5G23270.1; AT5G23270.
DR GeneID; 832391; -.
DR Gramene; AT5G23270.1; AT5G23270.1; AT5G23270.
DR KEGG; ath:AT5G23270; -.
DR Araport; AT5G23270; -.
DR TAIR; locus:2166781; AT5G23270.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_001265_30_5_1; -.
DR InParanoid; Q9FMX3; -.
DR OMA; AIVCCYQ; -.
DR OrthoDB; 430696at2759; -.
DR PhylomeDB; Q9FMX3; -.
DR PRO; PR:Q9FMX3; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FMX3; baseline and differential.
DR Genevisible; Q9FMX3; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0090406; C:pollen tube; IDA:TAIR.
DR GO; GO:0015145; F:monosaccharide transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR CDD; cd17361; MFS_STP; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR044778; MFS_STP/MST-like_plant.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR045262; STP/PLT_plant.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR PANTHER; PTHR23500; PTHR23500; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Sugar transport; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..514
FT /note="Sugar transport protein 11"
FT /id="PRO_0000050441"
FT TOPO_DOM 1..19
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..82
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..112
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..137
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..169
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 191..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..290
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 312..320
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 342..350
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 372..389
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 390..410
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 411..428
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 429..449
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 450..453
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 454..474
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 475..514
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 514 AA; 56725 MW; 0F9A05F0D7808C8D CRC64;
MAGGAFIDES GHGGDYEGRV TAFVMITCIV AAMGGLLFGY DIGISGGVIS MEDFLTKFFP
DVLRQMQNKR GRETEYCKYD NELLTLFTSS LYLAALFASF LASTITRLFG RKVSMVIGSL
AFLSGALLNG LAINLEMLII GRLFLGVGVG FANQSVPLYL SEMAPAKIRG ALNIGFQLAI
TIGILAANIV NYVTPKLQNG IGWRLSLGLA GVPAVMMLVG CFFLPDTPNS ILERGNKEKA
KEMLQKIRGT MEVEHEFNEL CNACEAAKKV KHPWTNIMQA RYRPQLTFCT FIPFFQQLTG
INVIMFYAPV LFKTIGFGND ASLISAVITG LVNVLSTIVS IYSVDKFGRR ALFLQGGFQM
IVTQIAVGSM IGWKFGFNGE GNLSGVDADI ILALICLYVA GFAWSWGPLG WLVPSEICPL
EIRSAGQSLN VSVNMFFTFF IGQFFLTMLC HMKFGLFYFF AGMVLIMTIF IYFLLPETKG
VPIEEMGKVW KEHRYWGKYS NNDDGDDVDD DAYF
