STP14_ARATH
ID STP14_ARATH Reviewed; 504 AA.
AC Q8GW61; O80655;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Sugar transport protein 14;
DE AltName: Full=Hexose transporter 14;
GN Name=STP14; OrderedLocusNames=At1g77210; ORFNames=T14N5.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Buettner M.;
RT "STP14, a new Arabidpsis monosaccharide transporter.";
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP GENE FAMILY.
RX PubMed=16923188; DOI=10.1186/1471-2148-6-64;
RA Johnson D.A., Hill J.P., Thomas M.A.;
RT "The monosaccharide transporter gene family in land plants is ancient and
RT shows differential subfamily expression and expansion across lineages.";
RL BMC Evol. Biol. 6:64-64(2006).
CC -!- FUNCTION: Mediates an active uptake of hexoses, probably by
CC sugar/hydrogen symport. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; AJ344334; CAC69070.1; -; mRNA.
DR EMBL; AC004260; AAC34349.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE35949.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE35950.1; -; Genomic_DNA.
DR EMBL; AK119057; BAC43633.1; -; mRNA.
DR EMBL; BT005887; AAO64822.1; -; mRNA.
DR PIR; T00450; T00450.
DR RefSeq; NP_001185417.1; NM_001198488.2.
DR RefSeq; NP_177845.1; NM_106370.5.
DR AlphaFoldDB; Q8GW61; -.
DR SMR; Q8GW61; -.
DR BioGRID; 29276; 5.
DR IntAct; Q8GW61; 2.
DR STRING; 3702.AT1G77210.1; -.
DR iPTMnet; Q8GW61; -.
DR PaxDb; Q8GW61; -.
DR PRIDE; Q8GW61; -.
DR ProteomicsDB; 228308; -.
DR EnsemblPlants; AT1G77210.1; AT1G77210.1; AT1G77210.
DR EnsemblPlants; AT1G77210.2; AT1G77210.2; AT1G77210.
DR GeneID; 844057; -.
DR Gramene; AT1G77210.1; AT1G77210.1; AT1G77210.
DR Gramene; AT1G77210.2; AT1G77210.2; AT1G77210.
DR KEGG; ath:AT1G77210; -.
DR Araport; AT1G77210; -.
DR TAIR; locus:2195995; AT1G77210.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_001265_30_5_1; -.
DR InParanoid; Q8GW61; -.
DR OMA; DANLFLC; -.
DR OrthoDB; 430696at2759; -.
DR PhylomeDB; Q8GW61; -.
DR PRO; PR:Q8GW61; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8GW61; baseline and differential.
DR Genevisible; Q8GW61; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0015145; F:monosaccharide transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR CDD; cd17361; MFS_STP; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR044778; MFS_STP/MST-like_plant.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR045262; STP/PLT_plant.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR PANTHER; PTHR23500; PTHR23500; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Sugar transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..504
FT /note="Sugar transport protein 14"
FT /id="PRO_0000050444"
FT TOPO_DOM 1..25
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..308
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..337
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 352..372
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..402
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 428..448
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 454..474
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 475..504
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 455
FT /note="I -> M (in Ref. 4 and 5)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 504 AA; 55386 MW; AC5E4418F879E1C7 CRC64;
MAGGALTDEG GLKRAHLYEH RITSYFIFAC IVGSMGGSLF GYDLGVSGGV TSMDDFLKEF
FPGIYKRKQM HLNETDYCKY DNQILTLFTS SLYFAGLIST FGASYVTRIY GRRGSILVGS
VSFFLGGVIN AAAKNILMLI LGRIFLGIGI GFGNQAVPLY LSEMAPAKIR GTVNQLFQLT
TCIGILVANL INYKTEQIHP WGWRLSLGLA TVPAILMFLG GLVLPETPNS LVEQGKLEKA
KAVLIKVRGT NNIEAEFQDL VEASDAARAV KNPFRNLLAR RNRPQLVIGA IGLPAFQQLT
GMNSILFYAP VMFQSLGFGG SASLISSTIT NAALVVAAIM SMYSADKFGR RFLLLEASVE
MFCYMVVVGV TLALKFGEGK ELPKSLGLIL VVLICLFVLA YGRSWGPMGW LVPSELFPLE
TRSAGQSVVV CVNLFFTALI AQCFLVSLCH LKYGIFLLFA GLILGMGSFV YFLLPETKQV
PIEEVYLLWR QHWLWKKYVE DVDE
