STP1_HUMAN
ID STP1_HUMAN Reviewed; 55 AA.
AC P09430;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Spermatid nuclear transition protein 1;
DE Short=STP-1;
DE Short=TP-1;
GN Name=TNP1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3412903; DOI=10.1093/nar/16.15.7723;
RA Luerssen H., Hoyer-Fender S., Engel W.;
RT "The nucleotide sequence of human transition protein 1 cDNA.";
RL Nucleic Acids Res. 16:7723-7723(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2249851; DOI=10.1016/0888-7543(90)90289-7;
RA Luerssen H., Mattei M.-G., Schroeter M., Grzeschik K.H., Adham I.M.,
RA Engel W.;
RT "Nucleotide sequence of the gene for human transition protein 1 and its
RT chromosomal localization on chromosome 2.";
RL Genomics 8:324-330(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=9809674; DOI=10.1093/molehr/4.10.939;
RA Steger K., Klonisch T., Gavenis K., Drabent B., Doenecke D., Bergmann M.;
RT "Expression of mRNA and protein of nucleoproteins during human
RT spermiogenesis.";
RL Mol. Hum. Reprod. 4:939-945(1998).
CC -!- FUNCTION: Plays a key role in the replacement of histones to protamine
CC in the elongating spermatids of mammals. In condensing spermatids,
CC loaded onto the nucleosomes, where it promotes the recruitment and
CC processing of protamines, which are responsible for histone eviction.
CC {ECO:0000250|UniProtKB:P10856}.
CC -!- INTERACTION:
CC P09430; Q92997: DVL3; NbExp=3; IntAct=EBI-10196343, EBI-739789;
CC P09430; Q9H190: SDCBP2; NbExp=4; IntAct=EBI-10196343, EBI-742426;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P10856}.
CC Chromosome {ECO:0000250|UniProtKB:P10856}. Note=Loaded onto the
CC nucleosomes of condensing spermatids. {ECO:0000250|UniProtKB:P10856}.
CC -!- TISSUE SPECIFICITY: Expressed by spermatids (at protein level).
CC {ECO:0000269|PubMed:9809674}.
CC -!- SIMILARITY: Belongs to the nuclear transition protein 1 family.
CC {ECO:0000305}.
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DR EMBL; M59924; AAA61202.1; -; Genomic_DNA.
DR EMBL; X07948; CAA30774.1; -; mRNA.
DR EMBL; BC029516; AAH29516.1; -; mRNA.
DR CCDS; CCDS2406.1; -.
DR PIR; A37106; BGHU.
DR RefSeq; NP_003275.1; NM_003284.3.
DR AlphaFoldDB; P09430; -.
DR BioGRID; 112995; 10.
DR IntAct; P09430; 2.
DR STRING; 9606.ENSP00000236979; -.
DR iPTMnet; P09430; -.
DR PhosphoSitePlus; P09430; -.
DR BioMuta; TNP1; -.
DR PaxDb; P09430; -.
DR PRIDE; P09430; -.
DR Antibodypedia; 34246; 120 antibodies from 23 providers.
DR DNASU; 7141; -.
DR Ensembl; ENST00000236979.2; ENSP00000236979.2; ENSG00000118245.2.
DR GeneID; 7141; -.
DR KEGG; hsa:7141; -.
DR MANE-Select; ENST00000236979.2; ENSP00000236979.2; NM_003284.4; NP_003275.1.
DR CTD; 7141; -.
DR DisGeNET; 7141; -.
DR GeneCards; TNP1; -.
DR HGNC; HGNC:11951; TNP1.
DR HPA; ENSG00000118245; Tissue enriched (testis).
DR MIM; 190231; gene.
DR neXtProt; NX_P09430; -.
DR OpenTargets; ENSG00000118245; -.
DR PharmGKB; PA36640; -.
DR VEuPathDB; HostDB:ENSG00000118245; -.
DR eggNOG; ENOG502TKT1; Eukaryota.
DR GeneTree; ENSGT00390000000539; -.
DR HOGENOM; CLU_3019482_0_0_1; -.
DR InParanoid; P09430; -.
DR OMA; FKSHGMR; -.
DR PhylomeDB; P09430; -.
DR TreeFam; TF338391; -.
DR PathwayCommons; P09430; -.
DR SignaLink; P09430; -.
DR BioGRID-ORCS; 7141; 31 hits in 1067 CRISPR screens.
DR GeneWiki; TNP1; -.
DR GenomeRNAi; 7141; -.
DR Pharos; P09430; Tbio.
DR PRO; PR:P09430; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; P09430; protein.
DR Bgee; ENSG00000118245; Expressed in sperm and 103 other tissues.
DR ExpressionAtlas; P09430; baseline and differential.
DR Genevisible; P09430; HS.
DR GO; GO:0001673; C:male germ cell nucleus; IBA:GO_Central.
DR GO; GO:0000786; C:nucleosome; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IMP:UniProtKB.
DR GO; GO:0006338; P:chromatin remodeling; IDA:UniProtKB.
DR GO; GO:0035042; P:fertilization, exchange of chromosomal proteins; TAS:UniProtKB.
DR GO; GO:0030317; P:flagellated sperm motility; IMP:UniProtKB.
DR GO; GO:0031507; P:heterochromatin assembly; IEP:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0006337; P:nucleosome disassembly; IMP:UniProtKB.
DR GO; GO:0010954; P:positive regulation of protein processing; ISS:UniProtKB.
DR GO; GO:0019953; P:sexual reproduction; IMP:UniProtKB.
DR GO; GO:0000012; P:single strand break repair; IDA:UniProtKB.
DR GO; GO:0007286; P:spermatid development; IDA:UniProtKB.
DR GO; GO:0007289; P:spermatid nucleus differentiation; TAS:UniProtKB.
DR GO; GO:0007290; P:spermatid nucleus elongation; IMP:UniProtKB.
DR GO; GO:0035093; P:spermatogenesis, exchange of chromosomal proteins; ISS:UniProtKB.
DR InterPro; IPR001319; Nuclear_transition_prot1.
DR InterPro; IPR020062; Nuclear_transition_prot1_CS.
DR PANTHER; PTHR17486; PTHR17486; 1.
DR Pfam; PF02079; TP1; 1.
DR PROSITE; PS00541; TP1; 1.
PE 1: Evidence at protein level;
KW Chromosome; Developmental protein; Differentiation; DNA-binding;
KW Nucleosome core; Nucleus; Phosphoprotein; Reference proteome;
KW Spermatogenesis.
FT CHAIN 1..55
FT /note="Spermatid nuclear transition protein 1"
FT /id="PRO_0000191417"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..38
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 9
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P22613"
FT MOD_RES 40
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P22613"
SQ SEQUENCE 55 AA; 6424 MW; E29C58EB2AADF3BB CRC64;
MSTSRKLKSH GMRRSKSRSP HKGVKRGGSK RKYRKGNLKS RKRGDDANRN YRSHL
