STP3_ARATH
ID STP3_ARATH Reviewed; 514 AA.
AC Q8L7R8; Q9ZS56;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 2.
DT 25-MAY-2022, entry version 124.
DE RecName: Full=Sugar transport protein 3;
DE AltName: Full=Hexose transporter 3;
GN Name=STP3; OrderedLocusNames=At5g61520; ORFNames=K11J9_40;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Baier K., Truernit E., Sauer N.;
RT "AtSTP3, a new stress-regulated monosaccharide-H+ symporter from
RT Arabidopsis thaliana.";
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9734815; DOI=10.1093/dnares/5.3.203;
RA Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence
RT features of the regions of 1,367,185 bp covered by 19 physically assigned
RT P1 and TAC clones.";
RL DNA Res. 5:203-216(1998).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY.
RX PubMed=16923188; DOI=10.1186/1471-2148-6-64;
RA Johnson D.A., Hill J.P., Thomas M.A.;
RT "The monosaccharide transporter gene family in land plants is ancient and
RT shows differential subfamily expression and expansion across lineages.";
RL BMC Evol. Biol. 6:64-64(2006).
CC -!- FUNCTION: Mediates an active uptake of hexoses, probably by
CC sugar/hydrogen symport. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8L7R8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8L7R8-2; Sequence=VSP_017028;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to intron retention.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; AJ002399; CAA05384.1; -; mRNA.
DR EMBL; AB012239; BAB08997.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97478.1; -; Genomic_DNA.
DR EMBL; AY128303; AAM91109.1; -; mRNA.
DR EMBL; BT000560; AAN18129.1; -; mRNA.
DR RefSeq; NP_200960.2; NM_125545.4. [Q8L7R8-1]
DR AlphaFoldDB; Q8L7R8; -.
DR SMR; Q8L7R8; -.
DR BioGRID; 21517; 2.
DR IntAct; Q8L7R8; 2.
DR STRING; 3702.AT5G61520.1; -.
DR iPTMnet; Q8L7R8; -.
DR PaxDb; Q8L7R8; -.
DR PRIDE; Q8L7R8; -.
DR ProteomicsDB; 228363; -. [Q8L7R8-1]
DR EnsemblPlants; AT5G61520.1; AT5G61520.1; AT5G61520. [Q8L7R8-1]
DR GeneID; 836273; -.
DR Gramene; AT5G61520.1; AT5G61520.1; AT5G61520. [Q8L7R8-1]
DR KEGG; ath:AT5G61520; -.
DR Araport; AT5G61520; -.
DR TAIR; locus:2151596; AT5G61520.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_001265_30_5_1; -.
DR InParanoid; Q8L7R8; -.
DR OMA; GITWKEC; -.
DR PhylomeDB; Q8L7R8; -.
DR PRO; PR:Q8L7R8; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8L7R8; baseline and differential.
DR Genevisible; Q8L7R8; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015145; F:monosaccharide transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR CDD; cd17361; MFS_STP; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR044778; MFS_STP/MST-like_plant.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR045262; STP/PLT_plant.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR PANTHER; PTHR23500; PTHR23500; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Sugar transport;
KW Symport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..514
FT /note="Sugar transport protein 3"
FT /id="PRO_0000050433"
FT TOPO_DOM 1..19
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..144
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 327..347
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..376
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 392..412
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 430..450
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 456..476
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 477..514
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..166
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14593172"
FT /id="VSP_017028"
SQ SEQUENCE 514 AA; 55867 MW; 827521E570273899 CRC64;
MVAEEARKEA MAKSVSGGKI TYFVVASCVM AAMGGVIFGY DIGVSGGVMS MGPFLKRFFP
KVYKLQEEDR RRRGNSNNHY CLFNSQLLTS FTSSLYVSGL IATLLASSVT RSWGRKPSIF
LGGVSFLAGA ALGGSAQNVA MLIIARLLLG VGVGFANQSV PLYLSEMAPA KYRGAISNGF
QLCIGIGFLS ANVINYETQN IKHGWRISLA TAAIPASILT LGSLFLPETP NSIIQTTGDV
HKTELMLRRV RGTNDVQDEL TDLVEASSGS DTDSNAFLKL LQRKYRPELV MALVIPFFQQ
VTGINVVAFY APVLYRTVGF GESGSLMSTL VTGIVGTSST LLSMLVVDRI GRKTLFLIGG
LQMLVSQVTI GVIVMVADVH DGVIKEGYGY AVVVLVCVYV AGFGWSWGPL GWLVPSEIFP
LEIRSVAQSV TVAVSFVFTF AVAQSAPPML CKFRAGIFFF YGGWLVVMTV AVQLFLPETK
NVPIEKVVGL WEKHWFWRRM TSKRDIQETT ILSH
