STP4_CANAL
ID STP4_CANAL Reviewed; 376 AA.
AC Q5AH87; A0A1D8PGT7;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2017, sequence version 2.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Transcriptional regulator STP4;
GN Name=STP4; OrderedLocusNames=CAALFM_C203220CA;
GN ORFNames=CaO19.8527, CaO19.909;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP INDUCTION.
RX PubMed=15814841; DOI=10.1091/mbc.e05-01-0071;
RA Garcia-Sanchez S., Mavor A.L., Russell C.L., Argimon S., Dennison P.,
RA Enjalbert B., Brown A.J.;
RT "Global roles of Ssn6 in Tup1- and Nrg1-dependent gene regulation in the
RT fungal pathogen, Candida albicans.";
RL Mol. Biol. Cell 16:2913-2925(2005).
RN [5]
RP INDUCTION.
RX PubMed=16400181; DOI=10.1128/ec.5.1.180-191.2006;
RA Cheng G., Yeater K.M., Hoyer L.L.;
RT "Cellular and molecular biology of Candida albicans estrogen response.";
RL Eukaryot. Cell 5:180-191(2006).
RN [6]
RP INDUCTION, AND FUNCTION.
RX PubMed=16552442; DOI=10.1371/journal.ppat.0020021;
RA Bruno V.M., Kalachikov S., Subaran R., Nobile C.J., Kyratsous C.,
RA Mitchell A.P.;
RT "Control of the C. albicans cell wall damage response by transcriptional
RT regulator Cas5.";
RL PLoS Pathog. 2:E21-E21(2006).
RN [7]
RP INDUCTION.
RX PubMed=22265407; DOI=10.1016/j.cell.2011.10.048;
RA Nobile C.J., Fox E.P., Nett J.E., Sorrells T.R., Mitrovich Q.M.,
RA Hernday A.D., Tuch B.B., Andes D.R., Johnson A.D.;
RT "A recently evolved transcriptional network controls biofilm development in
RT Candida albicans.";
RL Cell 148:126-138(2012).
CC -!- FUNCTION: Probable transcription factor involved in response to cell
CC wall damage. {ECO:0000269|PubMed:16552442}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- INDUCTION: Induced in biofilm, by caspofugin, as well as by 17-beta-
CC estradiol and ethynyl estradiol. Expression is regulated by SSN6.
CC {ECO:0000269|PubMed:15814841, ECO:0000269|PubMed:16400181,
CC ECO:0000269|PubMed:16552442, ECO:0000269|PubMed:22265407}.
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DR EMBL; CP017624; AOW27358.1; -; Genomic_DNA.
DR RefSeq; XP_721028.2; XM_715935.2.
DR AlphaFoldDB; Q5AH87; -.
DR STRING; 237561.Q5AH87; -.
DR PRIDE; Q5AH87; -.
DR GeneID; 3637405; -.
DR KEGG; cal:CAALFM_C203220CA; -.
DR CGD; CAL0000184778; STP4.
DR VEuPathDB; FungiDB:C2_03220C_A; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_035625_2_0_1; -.
DR InParanoid; Q5AH87; -.
DR OMA; FTINMIK; -.
DR OrthoDB; 1284504at2759; -.
DR PRO; PR:Q5AH87; -.
DR Proteomes; UP000000559; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..376
FT /note="Transcriptional regulator STP4"
FT /id="PRO_0000426060"
FT ZN_FING 241..263
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 25..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 137..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 376 AA; 42414 MW; EB7C7720D2BB1BF2 CRC64;
MLSMAVTPSN TLTSQYPTKQ ENYNQNYCSI KSPSPTSTPT STSLTMTSPP QLHNPHASIT
LPSIHSLDIP AFPHYEQEYS RASVFQNYSS NSPTPSNSSY SPTLLIPSND RPASSSVYSN
SSSTLLLSPG MSTTPNVNCI APVSRPRSTS NLTENSEQSF TSQQSHPAIS SNATITSPQL
SVKSENEQLH EPQNSNTIIS PRQNKKNWKP RKKKQCPECN LYFSNLATHK STHLKPNNRP
HICKYCERGF ARPNDLFRHV KCHWKEIGSD QGQFKCPFKN IDSSKRENQE KVTGNTGVPD
HCCHNTGIFS RCDTFKNHLK AIHFQYPNGT KKEQRNLVNG KCRMCQQEFR NVDDWMHNHI
ETNSCPYAIN LIKKEH
