ID   STP4_PIG                Reviewed;         138 AA.
AC   Q09821;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Spermatid nuclear transition protein 4;
DE            Short=STP-4;
DE            Short=TP-4;
DE            Short=TP4;
GN   Name=TNP4;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Spermatid;
RX   PubMed=7588743; DOI=10.1111/j.1432-1033.1995.179_1.x;
RA   Akama K., Ichimura H., Sato H., Kojima S., Miura K., Hayashi H.,
RA   Komatsu Y., Nakano M.;
RT   "The amino acid sequence and interaction with the nucleosome core DNA of
RT   transition protein 4 from boar late spermatid nuclei.";
RL   Eur. J. Biochem. 233:179-185(1995).
CC   -!- FUNCTION: Involved in nuclear basic protein transition: histones are
CC       replaced by spermatid specific proteins which are themselves replaced
CC       by protamines in late spermatids.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- DOMAIN: The N-terminal half is highly basic.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; S67968; S67968.
DR   AlphaFoldDB; Q09821; -.
DR   PaxDb; Q09821; -.
DR   eggNOG; ENOG502TD5A; Eukaryota.
DR   HOGENOM; CLU_1844497_0_0_1; -.
DR   InParanoid; Q09821; -.
DR   OMA; IMEKPTT; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   Genevisible; Q09821; SS.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR040433; Spermatid_TP.
DR   PANTHER; PTHR37876; PTHR37876; 1.
PE   1: Evidence at protein level;
KW   Chromosome; Developmental protein; Differentiation;
KW   Direct protein sequencing; DNA-binding; Nucleosome core; Nucleus;
KW   Phosphoprotein; Reference proteome; Spermatogenesis.
FT   CHAIN           1..138
FT                   /note="Spermatid nuclear transition protein 4"
FT                   /id="PRO_0000191436"
FT   REGION          1..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           5..23
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   MOTIF           54..72
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..16
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..31
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..76
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..109
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            126
FT                   /note="Binding to nucleic acids"
FT   MOD_RES         4
FT                   /note="Phosphoserine; by PKC"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         26
FT                   /note="Phosphothreonine; by PKA"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   138 AA;  16223 MW;  3FBD7131B0C8B6BE CRC64;
     AKVSRKPREP RTAVTQSTRR IKRKKTLSKP RSRGGVKAPK TTMKIKRALR RNLRRKIQTS
     AGQPKKAKKA RKHFVSYYVL KKSGQNKKTN QNKRQNQNKR QNQNKRRGQP VPEQEIMEKP
     TTSCKWCSQG VTRRGRRY