STP6_ARATH
ID STP6_ARATH Reviewed; 507 AA.
AC Q9SFG0; O81704;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Sugar transport protein 6;
DE AltName: Full=Hexose transporter 6;
GN Name=STP6; OrderedLocusNames=At3g05960; ORFNames=F2O10.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ACTIVITY REGULATION, DEVELOPMENTAL
RP STAGE, BIOPHYSICOCHEMICAL PROPERTIES, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia; TISSUE=Flower;
RX PubMed=12529516; DOI=10.1104/pp.012666;
RA Scholz-Starke J., Buettner M., Sauer N.;
RT "AtSTP6, a new pollen-specific H(+)-monosaccharide symporter from
RT Arabidopsis.";
RL Plant Physiol. 131:70-77(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 400-467.
RC STRAIN=cv. C24;
RA Baier K., Truernit E., Sauer N.;
RL Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=16923188; DOI=10.1186/1471-2148-6-64;
RA Johnson D.A., Hill J.P., Thomas M.A.;
RT "The monosaccharide transporter gene family in land plants is ancient and
RT shows differential subfamily expression and expansion across lineages.";
RL BMC Evol. Biol. 6:64-64(2006).
CC -!- FUNCTION: Mediates an active uptake of hexoses, probably by
CC sugar/hydrogen symport. Can transport glucose, 3-O-methylglucose,
CC mannose, fructose and galactose, and, to a lower extent, xylose and
CC ribulose. {ECO:0000269|PubMed:12529516}.
CC -!- ACTIVITY REGULATION: Inhibited by uncouplers such as 2,4-dinitrophenol
CC and carbonyl cyanide-m-chlorophenyl-hydrazone.
CC {ECO:0000269|PubMed:12529516}.
CC -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC Kinetic parameters:
CC KM=20.5 uM for glucose (at pH 5.5) {ECO:0000269|PubMed:12529516};
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Pollen specific. {ECO:0000269|PubMed:12529516}.
CC -!- DEVELOPMENTAL STAGE: First observed in pollen right before the opening
CC of floral buds. Levels increase during pollen maturation.
CC {ECO:0000269|PubMed:12529516}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; AJ344337; CAC69073.1; -; mRNA.
DR EMBL; AC013454; AAF23220.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74323.1; -; Genomic_DNA.
DR EMBL; AJ001659; CAA04904.1; -; Genomic_DNA.
DR RefSeq; NP_187247.1; NM_111470.2.
DR AlphaFoldDB; Q9SFG0; -.
DR SMR; Q9SFG0; -.
DR STRING; 3702.AT3G05960.1; -.
DR TCDB; 2.A.1.1.56; the major facilitator superfamily (mfs).
DR PaxDb; Q9SFG0; -.
DR PRIDE; Q9SFG0; -.
DR ProteomicsDB; 228267; -.
DR EnsemblPlants; AT3G05960.1; AT3G05960.1; AT3G05960.
DR GeneID; 819766; -.
DR Gramene; AT3G05960.1; AT3G05960.1; AT3G05960.
DR KEGG; ath:AT3G05960; -.
DR Araport; AT3G05960; -.
DR TAIR; locus:2083003; AT3G05960.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_001265_30_5_1; -.
DR InParanoid; Q9SFG0; -.
DR OMA; FGRKWPW; -.
DR OrthoDB; 430696at2759; -.
DR PhylomeDB; Q9SFG0; -.
DR PRO; PR:Q9SFG0; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SFG0; baseline and differential.
DR Genevisible; Q9SFG0; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015145; F:monosaccharide transmembrane transporter activity; IDA:TAIR.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0034219; P:carbohydrate transmembrane transport; TAS:TAIR.
DR CDD; cd17361; MFS_STP; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR044778; MFS_STP/MST-like_plant.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR045262; STP/PLT_plant.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR PANTHER; PTHR23500; PTHR23500; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Sugar transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..507
FT /note="Sugar transport protein 6"
FT /id="PRO_0000050436"
FT TOPO_DOM 1..20
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..41
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 280..300
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..365
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 418..438
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 447..467
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 468..507
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 507 AA; 55907 MW; FC8060B57C4DA810 CRC64;
MAVVVSNANA PAFEAKMTVY VFICVMIAAV GGLIFGYDIG ISGGVSAMDD FLKEFFPAVW
ERKKHVHENN YCKYDNQFLQ LFTSSLYLAA LVASFVASAT CSKLGRRPTM QFASIFFLIG
VGLTAGAVNL VMLIIGRLFL GFGVGFGNQA VPLFLSEIAP AQLRGGLNIV FQLMVTIGIL
IANIVNYFTA TVHPYGWRIA LGGAGIPAVI LLFGSLLIIE TPTSLIERNK NEEGKEALRK
IRGVDDINDE YESIVHACDI ASQVKDPYRK LLKPASRPPF IIGMLLQLFQ QFTGINAIMF
YAPVLFQTVG FGSDAALLSA VITGSINVLA TFVGIYLVDR TGRRFLLLQS SVHMLICQLI
IGIILAKDLG VTGTLGRPQA LVVVIFVCVY VMGFAWSWGP LGWLIPSETF PLETRSAGFA
VAVSCNMFFT FVIAQAFLSM LCGMRSGIFF FFSGWIIVMG LFAFFFIPET KGIAIDDMRE
SVWKPHWFWK RYMLPEDDHH DIEKRNA
