STP7_ARATH
ID STP7_ARATH Reviewed; 513 AA.
AC O04249; O04262; O81705;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Sugar transport protein 7;
DE AltName: Full=Hexose transporter 7;
GN Name=STP7; OrderedLocusNames=At4g02050; ORFNames=AGAA.1, T10M13.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Buettner M.;
RT "STP7 a new Arabidopsis monosaccharide transporter.";
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-233.
RC STRAIN=cv. Landsberg erecta;
RA Till S., Granat S., Parnell L., Kaplan N., Hoffman J., Lodhi M.,
RA Johnson A.F., Dedhia N., Martienssen R., McCombie W.R.;
RT "A. thaliana cosmid AGAA.";
RL Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 406-473.
RC STRAIN=cv. C24;
RA Baier K., Truernit E., Sauer N.;
RL Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE
RP ANALYSIS].
RX PubMed=15060130; DOI=10.1074/mcp.m400001-mcp200;
RA Marmagne A., Rouet M.-A., Ferro M., Rolland N., Alcon C., Joyard J.,
RA Garin J., Barbier-Brygoo H., Ephritikhine G.;
RT "Identification of new intrinsic proteins in Arabidopsis plasma membrane
RT proteome.";
RL Mol. Cell. Proteomics 3:675-691(2004).
RN [7]
RP GENE FAMILY.
RX PubMed=16923188; DOI=10.1186/1471-2148-6-64;
RA Johnson D.A., Hill J.P., Thomas M.A.;
RT "The monosaccharide transporter gene family in land plants is ancient and
RT shows differential subfamily expression and expansion across lineages.";
RL BMC Evol. Biol. 6:64-64(2006).
CC -!- FUNCTION: Mediates an active uptake of hexoses, probably by
CC sugar/hydrogen symport. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15060130};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; AJ344331; CAC69067.1; -; mRNA.
DR EMBL; AF001308; AAC78697.1; -; Genomic_DNA.
DR EMBL; AL161493; CAB80698.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE82116.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM67604.1; -; Genomic_DNA.
DR EMBL; AF001535; AAB57796.1; -; Genomic_DNA.
DR EMBL; AJ001660; CAA04905.1; -; Genomic_DNA.
DR PIR; T01506; T01506.
DR RefSeq; NP_001329423.1; NM_001340358.1.
DR RefSeq; NP_192114.1; NM_116436.6.
DR AlphaFoldDB; O04249; -.
DR SMR; O04249; -.
DR BioGRID; 13443; 2.
DR STRING; 3702.AT4G02050.1; -.
DR PaxDb; O04249; -.
DR PRIDE; O04249; -.
DR ProteomicsDB; 228268; -.
DR EnsemblPlants; AT4G02050.1; AT4G02050.1; AT4G02050.
DR EnsemblPlants; AT4G02050.2; AT4G02050.2; AT4G02050.
DR GeneID; 828154; -.
DR Gramene; AT4G02050.1; AT4G02050.1; AT4G02050.
DR Gramene; AT4G02050.2; AT4G02050.2; AT4G02050.
DR KEGG; ath:AT4G02050; -.
DR Araport; AT4G02050; -.
DR TAIR; locus:2132213; AT4G02050.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_001265_30_5_1; -.
DR InParanoid; O04249; -.
DR OMA; EMIFLWR; -.
DR OrthoDB; 430696at2759; -.
DR PhylomeDB; O04249; -.
DR PRO; PR:O04249; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; O04249; baseline and differential.
DR Genevisible; O04249; AT.
DR GO; GO:0012505; C:endomembrane system; IDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0090406; C:pollen tube; IDA:TAIR.
DR GO; GO:0042900; F:arabinose transmembrane transporter activity; IDA:TAIR.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0042882; P:L-arabinose transmembrane transport; IDA:TAIR.
DR CDD; cd17361; MFS_STP; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR044778; MFS_STP/MST-like_plant.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR045262; STP/PLT_plant.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR PANTHER; PTHR23500; PTHR23500; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Sugar transport; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..513
FT /note="Sugar transport protein 7"
FT /id="PRO_0000050437"
FT TOPO_DOM 1..26
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 121..141
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..407
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..447
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 452..472
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 473..513
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CONFLICT 233
FT /note="E -> D (in Ref. 4; AAB57796)"
FT /evidence="ECO:0000305"
FT CONFLICT 439
FT /note="I -> V (in Ref. 5; CAA04905)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 513 AA; 55829 MW; A5570287432C442C CRC64;
MAGGSFGPTG VAKERAEQYQ GKVTSYVIIA CLVAAIGGSI FGYDIGISGG VTSMDEFLEE
FFHTVYEKKK QAHESNYCKY DNQGLAAFTS SLYLAGLVST LVASPITRNY GRRASIVCGG
ISFLIGSGLN AGAVNLAMLL AGRIMLGVGI GFGNQAVPLY LSEVAPTHLR GGLNMMFQLA
TTIGIFTANM VNYGTQQLKP WGWRLSLGLA AFPALLMTLG GYFLPETPNS LVERGLTERG
RRVLVKLRGT ENVNAELQDM VDASELANSI KHPFRNILQK RHRPQLVMAI CMPMFQILTG
INSILFYAPV LFQTMGFGGN ASLYSSALTG AVLVLSTFIS IGLVDRLGRR ALLITGGIQM
IICQVIVAVI LGVKFGDNQE LSKGYSVIVV IFICLFVVAF GWSWGPLGWT IPSEIFPLET
RSAGQSITVA VNLLFTFIIA QAFLGLLCAF KFGIFLFFAG WVTVMTIFVY FLLPETKGVP
IEEMTLLWSK HWFWKKVLPD ATNLEDESKN VSV
