STP8_ARATH
ID STP8_ARATH Reviewed; 507 AA.
AC Q9SBA7; O81492; Q0WLP9;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Sugar transport protein 8;
DE AltName: Full=Hexose transporter 8;
GN Name=STP8; OrderedLocusNames=At5g26250; ORFNames=F9D12.9, T19G15.100;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Buettner M.;
RT "STP8 a new Arabidopsis monosaccharide transporter.";
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 349-507.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 401-468.
RC STRAIN=cv. C24;
RA Baier K., Truernit E., Sauer N.;
RT "AtSTP3, a new stress-regulated monosaccharide-H+ symporter from
RT Arabidopsis thaliana.";
RL Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY.
RX PubMed=16923188; DOI=10.1186/1471-2148-6-64;
RA Johnson D.A., Hill J.P., Thomas M.A.;
RT "The monosaccharide transporter gene family in land plants is ancient and
RT shows differential subfamily expression and expansion across lineages.";
RL BMC Evol. Biol. 6:64-64(2006).
CC -!- FUNCTION: Mediates an active uptake of hexoses, probably by
CC sugar/hydrogen symport. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; AJ344332; CAC69068.1; -; mRNA.
DR EMBL; AF077407; AAC26232.1; -; Genomic_DNA.
DR EMBL; CP002688; AED93541.1; -; Genomic_DNA.
DR EMBL; AK230144; BAF01958.1; -; mRNA.
DR EMBL; AJ001661; CAA04906.1; -; Genomic_DNA.
DR PIR; T01844; T01844.
DR RefSeq; NP_197997.1; NM_122526.2.
DR AlphaFoldDB; Q9SBA7; -.
DR SMR; Q9SBA7; -.
DR BioGRID; 17969; 3.
DR IntAct; Q9SBA7; 1.
DR STRING; 3702.AT5G26250.1; -.
DR PaxDb; Q9SBA7; -.
DR PRIDE; Q9SBA7; -.
DR ProteomicsDB; 228359; -.
DR EnsemblPlants; AT5G26250.1; AT5G26250.1; AT5G26250.
DR GeneID; 832694; -.
DR Gramene; AT5G26250.1; AT5G26250.1; AT5G26250.
DR KEGG; ath:AT5G26250; -.
DR Araport; AT5G26250; -.
DR TAIR; locus:2179734; AT5G26250.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_001265_30_5_1; -.
DR InParanoid; Q9SBA7; -.
DR OMA; NAASNWF; -.
DR OrthoDB; 430696at2759; -.
DR PhylomeDB; Q9SBA7; -.
DR PRO; PR:Q9SBA7; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9SBA7; baseline and differential.
DR Genevisible; Q9SBA7; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0090406; C:pollen tube; IDA:TAIR.
DR GO; GO:0015145; F:monosaccharide transmembrane transporter activity; IDA:TAIR.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0015749; P:monosaccharide transmembrane transport; IDA:TAIR.
DR CDD; cd17361; MFS_STP; 1.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR044778; MFS_STP/MST-like_plant.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR045262; STP/PLT_plant.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR PANTHER; PTHR23500; PTHR23500; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00879; SP; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Sugar transport; Symport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..507
FT /note="Sugar transport protein 8"
FT /id="PRO_0000050438"
FT TOPO_DOM 1..21
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 22..42
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..339
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TRANSMEM 346..366
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..402
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TRANSMEM 419..439
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TRANSMEM 448..468
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 469..507
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 507 AA; 56118 MW; F68DC11DDC0D350B CRC64;
MAVVISSNGN SKSFDAKMTV YVFICVIIAA VGGLIFGYDI GISGGVTAMD DFLKEFFPSV
YERKKHAHEN NYCKYDNQFL QLFTSSLYLA ALVASFFASA TCSKLGRRPT MQLASIFFLI
GVGLAAGAVN IYMLIIGRIL LGFGVGFGNQ AVPLFLSEIA PARLRGGLNI VFQLMVTIGI
LIANIVNYFT SSIHPYGWRI ALGGAGIPAL ILLFGSLLIC ETPTSLIERN KTKEGKETLK
KIRGVEDVDE EYESIVHACD IARQVKDPYT KLMKPASRPP FVIGMLLQFF QQFTGINAIM
FYAPVLFQTV GFGNDAALLS AVVTGTINVL STFVGIFLVD KTGRRFLLLQ SSVHMLICQL
VIGIILAKDL DVTGTLARPQ ALVVVIFVCV YVMGFAWSWG PLGWLIPSET FPLETRTEGF
ALAVSCNMFF TFVIAQAFLS MLCAMKSGIF FFFSGWIVVM GLFALFFVPE TKGVSIDDMR
DSVWKLHWYW KRFMLEEDEH DVEKRTD
