ID   STPA_ECO57              Reviewed;         134 AA.
AC   P0ACG2; P30017;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=DNA-binding protein StpA;
DE   AltName: Full=H-NS homolog StpA;
GN   Name=stpA; OrderedLocusNames=Z3968, ECs3530;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: A DNA-binding protein that acts in a fashion similar to H-NS,
CC       repressing gene transcription. A subset of H-NS/StpA-regulated genes
CC       require auxillary proteins for repression; these auxillary proteins
CC       (Hha and other similar proteins) may also modulate oligomerization of
CC       the H-NS/StpA complex (By similarity). {ECO:0000250|UniProtKB:P0ACG1}.
CC   -!- SUBUNIT: Forms homodimers, can interact with H-NS. May interact with
CC       Hha and/or Cnu. {ECO:0000250|UniProtKB:P0ACG1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid
CC       {ECO:0000250|UniProtKB:P0ACG1}.
CC   -!- SIMILARITY: Belongs to the histone-like protein H-NS family.
CC       {ECO:0000305}.
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DR   EMBL; AE005174; AAG57777.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB36953.1; -; Genomic_DNA.
DR   PIR; B91070; B91070.
DR   PIR; E85914; E85914.
DR   RefSeq; NP_311557.1; NC_002695.1.
DR   RefSeq; WP_000115383.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0ACG2; -.
DR   BMRB; P0ACG2; -.
DR   SMR; P0ACG2; -.
DR   STRING; 155864.EDL933_3832; -.
DR   EnsemblBacteria; AAG57777; AAG57777; Z3968.
DR   EnsemblBacteria; BAB36953; BAB36953; ECs_3530.
DR   GeneID; 66673461; -.
DR   GeneID; 914754; -.
DR   KEGG; ece:Z3968; -.
DR   KEGG; ecs:ECs_3530; -.
DR   PATRIC; fig|386585.9.peg.3684; -.
DR   eggNOG; COG2916; Bacteria.
DR   HOGENOM; CLU_117503_0_0_6; -.
DR   OMA; NTWLELM; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.287.1050; -; 1.
DR   Gene3D; 4.10.430.10; -; 1.
DR   InterPro; IPR027444; H-NS_C_dom.
DR   InterPro; IPR037150; H-NS_C_dom_sf.
DR   InterPro; IPR001801; Histone_HNS.
DR   InterPro; IPR027454; Histone_HNS_N.
DR   Pfam; PF00816; Histone_HNS; 1.
DR   PIRSF; PIRSF002096; HnS; 1.
DR   SMART; SM00528; HNS; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Reference proteome.
FT   CHAIN           1..134
FT                   /note="DNA-binding protein StpA"
FT                   /id="PRO_0000168514"
FT   DNA_BIND        112..117
FT                   /evidence="ECO:0000250|UniProtKB:P0A1S2"
FT   REGION          73..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   134 AA;  15348 MW;  5870BD95F144CE6A CRC64;
     MSVMLQSLNN IRTLRAMARE FSIDVLEEML EKFRVVTKER REEEEQQQRE LAERQEKIST
     WLELMKADGI NPEELLGNSS AAAPRAGKKR QPRPAKYKFT DVNGETKTWT GQGRTPKPIA
     QALAEGKSLD DFLI