ID   STPA_SALTI              Reviewed;         133 AA.
AC   P0A1S5; O33800;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=DNA-binding protein StpA;
DE   AltName: Full=H-NS homolog StpA;
GN   Name=stpA; OrderedLocusNames=STY2920, t2695;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: A DNA-binding protein that acts in a fashion similar to H-NS,
CC       repressing gene transcription. A subset of H-NS/StpA-regulated genes
CC       require auxillary proteins for repression; these auxillary proteins
CC       (Hha and other similar proteins) may also modulate oligomerization of
CC       the H-NS/StpA complex (By similarity). {ECO:0000250|UniProtKB:P0ACG1}.
CC   -!- SUBUNIT: Forms homodimers, can interact with H-NS.
CC       {ECO:0000250|UniProtKB:P0ACG1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid
CC       {ECO:0000250|UniProtKB:P0ACG1}.
CC   -!- SIMILARITY: Belongs to the histone-like protein H-NS family.
CC       {ECO:0000305}.
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DR   EMBL; AL513382; CAD05909.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO70263.1; -; Genomic_DNA.
DR   RefSeq; NP_457198.1; NC_003198.1.
DR   RefSeq; WP_001051100.1; NZ_WSUR01000031.1.
DR   AlphaFoldDB; P0A1S5; -.
DR   SMR; P0A1S5; -.
DR   STRING; 220341.16503882; -.
DR   EnsemblBacteria; AAO70263; AAO70263; t2695.
DR   KEGG; stt:t2695; -.
DR   KEGG; sty:STY2920; -.
DR   PATRIC; fig|220341.7.peg.2973; -.
DR   eggNOG; COG2916; Bacteria.
DR   HOGENOM; CLU_117503_0_0_6; -.
DR   OMA; NTWLELM; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.287.1050; -; 1.
DR   Gene3D; 4.10.430.10; -; 1.
DR   InterPro; IPR027444; H-NS_C_dom.
DR   InterPro; IPR037150; H-NS_C_dom_sf.
DR   InterPro; IPR001801; Histone_HNS.
DR   InterPro; IPR027454; Histone_HNS_N.
DR   Pfam; PF00816; Histone_HNS; 1.
DR   PIRSF; PIRSF002096; HnS; 1.
DR   SMART; SM00528; HNS; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding.
FT   CHAIN           1..133
FT                   /note="DNA-binding protein StpA"
FT                   /id="PRO_0000168515"
FT   DNA_BIND        111..116
FT                   /evidence="ECO:0000250|UniProtKB:P0A1S2"
FT   REGION          81..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   133 AA;  15488 MW;  86861AA6ED6E1AFB CRC64;
     MNLMLQNLNN IRTLRAMARE FSIDVLEEML EKFRVVTKER REEEELQQRQ LAEKQEKINA
     FLELMKADGI NPEELFAMDS AMPRSAKKRQ PRPAKYRFTD FNGEEKTWTG QGRTPKPIAQ
     ALAAGKSLDD FLI