ID   STPA_SHIFL              Reviewed;         134 AA.
AC   P0ACG3; P30017;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=DNA-binding protein StpA;
DE   AltName: Full=H-NS homolog StpA;
GN   Name=stpA; OrderedLocusNames=SF2697, S2883;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: A DNA-binding protein that acts in a fashion similar to H-NS,
CC       repressing gene transcription. A subset of H-NS/StpA-regulated genes
CC       require auxillary proteins for repression; these auxillary proteins
CC       (Hha and other similar proteins) may also modulate oligomerization of
CC       the H-NS/StpA complex (By similarity). {ECO:0000250|UniProtKB:P0ACG1}.
CC   -!- SUBUNIT: Forms homodimers, can interact with H-NS. May interact with
CC       Hha and/or Cnu. {ECO:0000250|UniProtKB:P0ACG1}.
CC   -!- INTERACTION:
CC       P0ACG3; P0ACG3: stpA; NbExp=2; IntAct=EBI-2011670, EBI-2011670;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid
CC       {ECO:0000250|UniProtKB:P0ACG1}.
CC   -!- SIMILARITY: Belongs to the histone-like protein H-NS family.
CC       {ECO:0000305}.
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DR   EMBL; AE005674; AAN44190.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP18018.1; -; Genomic_DNA.
DR   RefSeq; NP_708483.1; NC_004337.2.
DR   RefSeq; WP_000115383.1; NZ_WPGW01000014.1.
DR   AlphaFoldDB; P0ACG3; -.
DR   BMRB; P0ACG3; -.
DR   SMR; P0ACG3; -.
DR   IntAct; P0ACG3; 2.
DR   STRING; 198214.SF2697; -.
DR   EnsemblBacteria; AAN44190; AAN44190; SF2697.
DR   EnsemblBacteria; AAP18018; AAP18018; S2883.
DR   GeneID; 1027464; -.
DR   GeneID; 66673461; -.
DR   KEGG; sfl:SF2697; -.
DR   KEGG; sfx:S2883; -.
DR   PATRIC; fig|198214.7.peg.3212; -.
DR   HOGENOM; CLU_117503_0_0_6; -.
DR   OMA; NTWLELM; -.
DR   OrthoDB; 1911889at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.287.1050; -; 1.
DR   Gene3D; 4.10.430.10; -; 1.
DR   InterPro; IPR027444; H-NS_C_dom.
DR   InterPro; IPR037150; H-NS_C_dom_sf.
DR   InterPro; IPR001801; Histone_HNS.
DR   InterPro; IPR027454; Histone_HNS_N.
DR   Pfam; PF00816; Histone_HNS; 1.
DR   PIRSF; PIRSF002096; HnS; 1.
DR   SMART; SM00528; HNS; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; DNA-binding; Reference proteome.
FT   CHAIN           1..134
FT                   /note="DNA-binding protein StpA"
FT                   /id="PRO_0000168517"
FT   DNA_BIND        112..117
FT                   /evidence="ECO:0000250|UniProtKB:P0A1S2"
FT   REGION          73..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   134 AA;  15348 MW;  5870BD95F144CE6A CRC64;
     MSVMLQSLNN IRTLRAMARE FSIDVLEEML EKFRVVTKER REEEEQQQRE LAERQEKIST
     WLELMKADGI NPEELLGNSS AAAPRAGKKR QPRPAKYKFT DVNGETKTWT GQGRTPKPIA
     QALAEGKSLD DFLI