ID   STPG1_BOVIN             Reviewed;         335 AA.
AC   A6QQ60;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=O(6)-methylguanine-induced apoptosis 2;
DE            Short=MAPO2;
DE   AltName: Full=Sperm-tail PG-rich repeat-containing protein 1;
GN   Name=STPG1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May positively contribute to the induction of apoptosis
CC       triggered by O(6)-methylguanine. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the STPG1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC149661; AAI49662.1; -; mRNA.
DR   RefSeq; NP_001095774.1; NM_001102304.2.
DR   RefSeq; XP_005203313.1; XM_005203256.3.
DR   RefSeq; XP_015316044.1; XM_015460558.1.
DR   AlphaFoldDB; A6QQ60; -.
DR   PaxDb; A6QQ60; -.
DR   PRIDE; A6QQ60; -.
DR   Ensembl; ENSBTAT00000013576; ENSBTAP00000013576; ENSBTAG00000010278.
DR   Ensembl; ENSBTAT00000070402; ENSBTAP00000073904; ENSBTAG00000010278.
DR   Ensembl; ENSBTAT00000073643; ENSBTAP00000066283; ENSBTAG00000010278.
DR   GeneID; 616738; -.
DR   KEGG; bta:616738; -.
DR   CTD; 90529; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010278; -.
DR   VGNC; VGNC:35416; STPG1.
DR   eggNOG; ENOG502R2KG; Eukaryota.
DR   GeneTree; ENSGT00390000011598; -.
DR   HOGENOM; CLU_071847_0_0_1; -.
DR   InParanoid; A6QQ60; -.
DR   OMA; GQYENPI; -.
DR   OrthoDB; 1516381at2759; -.
DR   TreeFam; TF328937; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000010278; Expressed in spermatid and 73 other tissues.
DR   GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:1902110; P:positive regulation of mitochondrial membrane permeability involved in apoptotic process; IBA:GO_Central.
DR   InterPro; IPR010736; SHIPPO-rpt.
DR   Pfam; PF07004; SHIPPO-rpt; 3.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..335
FT                   /note="O(6)-methylguanine-induced apoptosis 2"
FT                   /id="PRO_0000305169"
FT   REPEAT          68..75
FT                   /note="STPGR 1"
FT   REPEAT          110..118
FT                   /note="STPGR 2"
FT   REPEAT          149..156
FT                   /note="STPGR 3"
FT   REPEAT          188..215
FT                   /note="STPGR 4"
FT   REPEAT          226..255
FT                   /note="STPGR 5"
FT   REPEAT          267..284
FT                   /note="STPGR 6"
FT   REPEAT          308..317
FT                   /note="STPGR 7"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         73
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5TH74"
SQ   SEQUENCE   335 AA;  37104 MW;  CA3B86908FF42AEE CRC64;
     MDNSTQKDQH SGKKYSRKAN KVQKGFTAAY PTQSSIPYKY QPLIIPESEK KGFNSQAKRF
     YHKQDDIPGP GFYNVIHQSP VFDSVSLSKK GTCTFPSMCA RLDTIVSKFP AANAYTIPSR
     LVSKKDFSNS CSSMFQLPSY EKVLKFETPA PNQYNASDSC CKQANNVCAR AGFVSKTQRG
     LFTVSKTGPA PGHYDVNESL VKQSPKILMS CFKSKTDRGL KLTSTGPGPG YYNPNGHPKV
     QKKTLIPRNP ILNFSAQPLP LPPKPPLPGP GQYEIVDYTG PRKHFISSAS FVSNTRRWTA
     GPSQPGMPGP ATYRPEFPGK QSFLYNEDNK WIPVL