STPG1_DANRE
ID STPG1_DANRE Reviewed; 320 AA.
AC A5WUY6; Q501Z0;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=O(6)-methylguanine-induced apoptosis 2;
DE Short=MAPO2;
DE AltName: Full=Sperm-tail PG-rich repeat-containing protein 1;
GN Name=stpg1; ORFNames=si:dkey-218f9.1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May positively contribute to the induction of apoptosis
CC triggered by O(6)-methylguanine. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the STPG1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH95808.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; CR853286; CAN88297.1; -; Genomic_DNA.
DR EMBL; BC095808; AAH95808.1; ALT_INIT; mRNA.
DR AlphaFoldDB; A5WUY6; -.
DR PaxDb; A5WUY6; -.
DR ZFIN; ZDB-GENE-070705-373; stpg1.
DR eggNOG; ENOG502R2KG; Eukaryota.
DR InParanoid; A5WUY6; -.
DR PhylomeDB; A5WUY6; -.
DR PRO; PR:A5WUY6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0001939; C:female pronucleus; IBA:GO_Central.
DR GO; GO:0042585; C:germinal vesicle; IBA:GO_Central.
DR GO; GO:0001940; C:male pronucleus; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0044727; P:DNA demethylation of male pronucleus; IBA:GO_Central.
DR GO; GO:1901537; P:positive regulation of DNA demethylation; IBA:GO_Central.
DR GO; GO:1902110; P:positive regulation of mitochondrial membrane permeability involved in apoptotic process; IBA:GO_Central.
DR InterPro; IPR010736; SHIPPO-rpt.
DR InterPro; IPR039345; STPG4.
DR PANTHER; PTHR35678; PTHR35678; 2.
DR Pfam; PF07004; SHIPPO-rpt; 2.
PE 2: Evidence at transcript level;
KW Apoptosis; Cytoplasm; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..320
FT /note="O(6)-methylguanine-induced apoptosis 2"
FT /id="PRO_0000305173"
FT REPEAT 49..82
FT /note="STPGR 1"
FT REPEAT 91..103
FT /note="STPGR 2"
FT REPEAT 132..163
FT /note="STPGR 3"
FT REPEAT 173..192
FT /note="STPGR 4"
FT REPEAT 213..233
FT /note="STPGR 5"
FT REPEAT 254..266
FT /note="STPGR 6"
FT REPEAT 294..305
FT /note="STPGR 7"
FT REGION 46..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 43
FT /note="E -> K (in Ref. 2; AAH95808)"
FT /evidence="ECO:0000305"
FT CONFLICT 166
FT /note="V -> F (in Ref. 2; AAH95808)"
FT /evidence="ECO:0000305"
FT CONFLICT 222
FT /note="Q -> L (in Ref. 2; AAH95808)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 320 AA; 35476 MW; 838737DB9500AF3E CRC64;
MGKLHRGLAE FNGCASSIPP KYQTVIISNE EKKGFSSQSR RFEEYLNESP GPGSYLSHSP
AEGCSPSFSK RGTGSFASKG GRVPRSFQRL SPGPDAYNLQ MSLLHKHDFN RGESRIFRLP
YALKKEKPNN ENPAPNQYDV SYRAVDKNST ISGESAFRSK TRRSAVVSDK FKGPSPCHYK
VSDVLVQKSP QALVSCFKSK TARIQSPVRN NIPGPGTYNP HQPPEPVKRT VLPRRYYLGL
SAPPLIPEKV PPFPGPGHYD IVNYNRPVKH MVSSAAFLSG TNRHMQEVKG QDIPGPGFYE
PTVLSKTSFL YNPAKLWIPA
