STPG1_HUMAN
ID STPG1_HUMAN Reviewed; 334 AA.
AC Q5TH74; Q49AP0; Q6P3R4; Q86VU9; Q8WVQ3;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=O(6)-methylguanine-induced apoptosis 2;
DE Short=MAPO2;
DE AltName: Full=Sperm-tail PG-rich repeat-containing protein 1;
GN Name=STPG1; Synonyms=C1orf201;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Brain, Lung, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-72, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [4]
RP FUNCTION.
RX PubMed=23028632; DOI=10.1371/journal.pone.0044817;
RA Fujikane R., Sanada M., Sekiguchi M., Hidaka M.;
RT "The identification of a novel gene, MAPO2, that is involved in the
RT induction of apoptosis triggered by O(6)-methylguanine.";
RL PLoS ONE 7:E44817-E44817(2012).
RN [5]
RP VARIANT [LARGE SCALE ANALYSIS] PHE-254.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: May positively contribute to the induction of apoptosis
CC triggered by O(6)-methylguanine. {ECO:0000269|PubMed:23028632}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5TH74-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5TH74-2; Sequence=VSP_028252;
CC Name=3;
CC IsoId=Q5TH74-3; Sequence=VSP_028253, VSP_028254;
CC -!- SIMILARITY: Belongs to the STPG1 family. {ECO:0000305}.
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DR EMBL; AL031431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC017650; AAH17650.1; -; mRNA.
DR EMBL; BC035061; AAH35061.1; -; mRNA.
DR EMBL; BC047705; AAH47705.1; -; mRNA.
DR EMBL; BC063891; AAH63891.1; -; mRNA.
DR CCDS; CCDS253.1; -. [Q5TH74-3]
DR CCDS; CCDS55581.1; -. [Q5TH74-1]
DR RefSeq; NP_001185941.1; NM_001199012.1. [Q5TH74-1]
DR RefSeq; NP_001185942.1; NM_001199013.1. [Q5TH74-1]
DR RefSeq; NP_001185943.1; NM_001199014.1. [Q5TH74-2]
DR RefSeq; NP_835223.1; NM_178122.4. [Q5TH74-3]
DR RefSeq; XP_006711088.1; XM_006711025.2. [Q5TH74-1]
DR RefSeq; XP_011540706.1; XM_011542404.1. [Q5TH74-1]
DR RefSeq; XP_016858257.1; XM_017002768.1. [Q5TH74-3]
DR RefSeq; XP_016858258.1; XM_017002769.1. [Q5TH74-2]
DR RefSeq; XP_016858259.1; XM_017002770.1. [Q5TH74-2]
DR AlphaFoldDB; Q5TH74; -.
DR BioGRID; 124732; 2.
DR STRING; 9606.ENSP00000363530; -.
DR iPTMnet; Q5TH74; -.
DR PhosphoSitePlus; Q5TH74; -.
DR BioMuta; STPG1; -.
DR DMDM; 74746565; -.
DR MassIVE; Q5TH74; -.
DR PaxDb; Q5TH74; -.
DR PeptideAtlas; Q5TH74; -.
DR PRIDE; Q5TH74; -.
DR ProteomicsDB; 65145; -. [Q5TH74-1]
DR ProteomicsDB; 65146; -. [Q5TH74-2]
DR ProteomicsDB; 65147; -. [Q5TH74-3]
DR Antibodypedia; 15730; 22 antibodies from 11 providers.
DR DNASU; 90529; -.
DR Ensembl; ENST00000003583.12; ENSP00000003583.8; ENSG00000001460.18. [Q5TH74-3]
DR Ensembl; ENST00000337248.9; ENSP00000337461.4; ENSG00000001460.18. [Q5TH74-1]
DR Ensembl; ENST00000374409.5; ENSP00000363530.1; ENSG00000001460.18. [Q5TH74-1]
DR GeneID; 90529; -.
DR KEGG; hsa:90529; -.
DR MANE-Select; ENST00000337248.9; ENSP00000337461.4; NM_001199013.2; NP_001185942.1.
DR UCSC; uc001bja.4; human. [Q5TH74-1]
DR CTD; 90529; -.
DR DisGeNET; 90529; -.
DR GeneCards; STPG1; -.
DR HGNC; HGNC:28070; STPG1.
DR HPA; ENSG00000001460; Tissue enhanced (testis).
DR MIM; 615826; gene.
DR neXtProt; NX_Q5TH74; -.
DR OpenTargets; ENSG00000001460; -.
DR PharmGKB; PA143485320; -.
DR VEuPathDB; HostDB:ENSG00000001460; -.
DR eggNOG; ENOG502R2KG; Eukaryota.
DR GeneTree; ENSGT00390000011598; -.
DR HOGENOM; CLU_071847_0_0_1; -.
DR InParanoid; Q5TH74; -.
DR OMA; GQYENPI; -.
DR OrthoDB; 1516381at2759; -.
DR PhylomeDB; Q5TH74; -.
DR TreeFam; TF328937; -.
DR PathwayCommons; Q5TH74; -.
DR BioGRID-ORCS; 90529; 10 hits in 1083 CRISPR screens.
DR GenomeRNAi; 90529; -.
DR Pharos; Q5TH74; Tbio.
DR PRO; PR:Q5TH74; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5TH74; protein.
DR Bgee; ENSG00000001460; Expressed in right testis and 122 other tissues.
DR ExpressionAtlas; Q5TH74; baseline and differential.
DR Genevisible; Q5TH74; HS.
DR GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IMP:UniProtKB.
DR GO; GO:1902110; P:positive regulation of mitochondrial membrane permeability involved in apoptotic process; IMP:UniProtKB.
DR InterPro; IPR010736; SHIPPO-rpt.
DR Pfam; PF07004; SHIPPO-rpt; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; Apoptosis; Cytoplasm; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat.
FT CHAIN 1..334
FT /note="O(6)-methylguanine-induced apoptosis 2"
FT /id="PRO_0000305170"
FT REPEAT 67..74
FT /note="STPGR 1"
FT REPEAT 109..117
FT /note="STPGR 2"
FT REPEAT 148..155
FT /note="STPGR 3"
FT REPEAT 187..206
FT /note="STPGR 4"
FT REPEAT 225..257
FT /note="STPGR 5"
FT REPEAT 267..282
FT /note="STPGR 6"
FT REPEAT 306..316
FT /note="STPGR 7"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 72
FT /note="Phosphotyrosine"
FT /evidence="ECO:0007744|PubMed:19690332"
FT VAR_SEQ 1..92
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028252"
FT VAR_SEQ 1..47
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028253"
FT VAR_SEQ 48..62
FT /note="EKKGFNSQAKRFPHK -> MNALANIPDVPVKYR (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028254"
FT VARIANT 254
FT /note="S -> F (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035614"
FT CONFLICT 93
FT /note="M -> T (in Ref. 2; AAH35061)"
FT /evidence="ECO:0000305"
FT CONFLICT 105
FT /note="I -> V (in Ref. 2; AAH35061)"
FT /evidence="ECO:0000305"
FT CONFLICT 163
FT /note="R -> I (in Ref. 2; AAH17650)"
FT /evidence="ECO:0000305"
FT CONFLICT 233
FT /note="P -> T (in Ref. 2; AAH35061)"
FT /evidence="ECO:0000305"
FT CONFLICT 332
FT /note="P -> R (in Ref. 2; AAH35061)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 334 AA; 36786 MW; 8DA37D63A36E478E CRC64;
MDNSAQKNER TGKHPRRASE VQKGFTAAYP TQSSIPFKSQ ASVIPESEKK GFNSQAKRFP
HKKNDIPGPG FYNVIHQSPV SNSVSLSKKG TCMFPSMCAR LDTIISKYPA ANAYTIPSDF
ISKRDFSNSC SSMFQLPSFM KALKFETPAP NYYNASVSCC KQRNNVCTRA GFMSKTQRGS
FAFADKGPPP GHYDINESLV KQSPNTLMSC FKSKTNRGLK LTSTGPGPGY YNPSDCTKVP
KKTLFPKNPI LNFSAQPSPL PPKPPFPGPG QYEIVDYLGP RKHFISSASF VSNTSRWTAA
PPQPGLPGPA TYKPELPGKQ SFLYNEDKKW IPVL
