STPG1_MOUSE
ID STPG1_MOUSE Reviewed; 341 AA.
AC Q9D2F5;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=O(6)-methylguanine-induced apoptosis 2;
DE Short=MAPO2;
DE AltName: Full=Sperm-tail PG-rich repeat-containing protein 1;
GN Name=Stpg1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP FUNCTION, DISRUPTION PHENOTYPE, AND SUBCELLULAR LOCATION.
RX PubMed=23028632; DOI=10.1371/journal.pone.0044817;
RA Fujikane R., Sanada M., Sekiguchi M., Hidaka M.;
RT "The identification of a novel gene, MAPO2, that is involved in the
RT induction of apoptosis triggered by O(6)-methylguanine.";
RL PLoS ONE 7:E44817-E44817(2012).
CC -!- FUNCTION: May positively contribute to the induction of apoptosis
CC triggered by O(6)-methylguanine. {ECO:0000269|PubMed:23028632}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23028632}. Nucleus
CC {ECO:0000269|PubMed:23028632}.
CC -!- DISRUPTION PHENOTYPE: After exposure to alkylating agent, significantly
CC suppresses the depolarization of the mitochondrial membrane and the
CC activation of BAK and caspase-3, all of which are hallmarks for the
CC induction of apoptosis. {ECO:0000269|PubMed:23028632}.
CC -!- SIMILARITY: Belongs to the STPG1 family. {ECO:0000305}.
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DR EMBL; AK019766; BAB31848.1; -; mRNA.
DR EMBL; AL670720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS18787.1; -.
DR RefSeq; NP_084465.1; NM_030189.3.
DR RefSeq; XP_006539348.1; XM_006539285.3.
DR RefSeq; XP_006539349.1; XM_006539286.3.
DR RefSeq; XP_006539350.1; XM_006539287.3.
DR RefSeq; XP_011248658.1; XM_011250356.2.
DR RefSeq; XP_011248659.1; XM_011250357.2.
DR AlphaFoldDB; Q9D2F5; -.
DR STRING; 10090.ENSMUSP00000067647; -.
DR iPTMnet; Q9D2F5; -.
DR PhosphoSitePlus; Q9D2F5; -.
DR PaxDb; Q9D2F5; -.
DR PRIDE; Q9D2F5; -.
DR ProteomicsDB; 257498; -.
DR Antibodypedia; 15730; 22 antibodies from 11 providers.
DR DNASU; 78806; -.
DR Ensembl; ENSMUST00000063707; ENSMUSP00000067647; ENSMUSG00000028801.
DR GeneID; 78806; -.
DR KEGG; mmu:78806; -.
DR UCSC; uc008vgp.1; mouse.
DR CTD; 90529; -.
DR MGI; MGI:1926056; Stpg1.
DR VEuPathDB; HostDB:ENSMUSG00000028801; -.
DR eggNOG; ENOG502R2KG; Eukaryota.
DR GeneTree; ENSGT00390000011598; -.
DR HOGENOM; CLU_071847_0_0_1; -.
DR InParanoid; Q9D2F5; -.
DR OMA; GQYENPI; -.
DR OrthoDB; 1516381at2759; -.
DR PhylomeDB; Q9D2F5; -.
DR TreeFam; TF328937; -.
DR BioGRID-ORCS; 78806; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Stpg1; mouse.
DR PRO; PR:Q9D2F5; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9D2F5; protein.
DR Bgee; ENSMUSG00000028801; Expressed in spermatid and 33 other tissues.
DR Genevisible; Q9D2F5; MM.
DR GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
DR GO; GO:1902110; P:positive regulation of mitochondrial membrane permeability involved in apoptotic process; ISO:MGI.
DR InterPro; IPR010736; SHIPPO-rpt.
DR Pfam; PF07004; SHIPPO-rpt; 4.
PE 2: Evidence at transcript level;
KW Apoptosis; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..341
FT /note="O(6)-methylguanine-induced apoptosis 2"
FT /id="PRO_0000305171"
FT REPEAT 73..81
FT /note="STPGR 1"
FT REPEAT 115..123
FT /note="STPGR 2"
FT REPEAT 154..160
FT /note="STPGR 3"
FT REPEAT 194..223
FT /note="STPGR 4"
FT REPEAT 232..255
FT /note="STPGR 5"
FT REPEAT 273..284
FT /note="STPGR 6"
FT REPEAT 313..323
FT /note="STPGR 7"
FT MOD_RES 78
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q5TH74"
SQ SEQUENCE 341 AA; 37499 MW; 6107E6612DAEE63B CRC64;
MSQKFANLDN VVLRADLDKP KKHADRVQKG FTAAYPTQSS IPYRHRTSII PESEKKGFNS
QARRFYSKKD DVPGPGFYNV IHQSPVFSSA SLSKRGTCTF PSTCARLGPI ISKNPAANAY
TIRSDLASKK DFSNSCSSMF QLPSFMKVEK SETPAPNHYN ASIASCRQKN NVCARAGFLS
KTPRGFIPSS ASGGPAPGHY NVNESLVRQS PKFLMSCFKS RTGRGLKPTS IGPGPGYYNP
NDQTKILKKS YFPKTTLLNF SAHPLPLPPK PPLPGPGQYE IVNYEGPPKH FISSASFVSN
TSRWPMKSSK PNLPGPATYK PEIPGKQSFL YNEDNKWVPA V
