ID   STPG1_RAT               Reviewed;         341 AA.
AC   Q4KLY8;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=O(6)-methylguanine-induced apoptosis 2;
DE            Short=MAPO2;
DE   AltName: Full=Sperm-tail PG-rich repeat-containing protein 1;
GN   Name=Stpg1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May positively contribute to the induction of apoptosis
CC       triggered by O(6)-methylguanine. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the STPG1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC098937; AAH98937.1; -; mRNA.
DR   RefSeq; NP_001020943.1; NM_001025772.1.
DR   RefSeq; XP_008762501.2; XM_008764279.2.
DR   RefSeq; XP_017449074.1; XM_017593585.1.
DR   RefSeq; XP_017449075.1; XM_017593586.1.
DR   RefSeq; XP_017449076.1; XM_017593587.1.
DR   RefSeq; XP_017449077.1; XM_017593588.1.
DR   AlphaFoldDB; Q4KLY8; -.
DR   PaxDb; Q4KLY8; -.
DR   PRIDE; Q4KLY8; -.
DR   Ensembl; ENSRNOT00000041600; ENSRNOP00000051024; ENSRNOG00000031448.
DR   GeneID; 500566; -.
DR   KEGG; rno:500566; -.
DR   UCSC; RGD:1560169; rat.
DR   CTD; 90529; -.
DR   RGD; 1560169; Stpg1.
DR   eggNOG; ENOG502R2KG; Eukaryota.
DR   GeneTree; ENSGT00390000011598; -.
DR   InParanoid; Q4KLY8; -.
DR   OMA; GQYENPI; -.
DR   OrthoDB; 1516381at2759; -.
DR   PhylomeDB; Q4KLY8; -.
DR   TreeFam; TF328937; -.
DR   PRO; PR:Q4KLY8; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000031448; Expressed in testis and 4 other tissues.
DR   Genevisible; Q4KLY8; RN.
DR   GO; GO:0005739; C:mitochondrion; IEA:GOC.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; ISO:RGD.
DR   GO; GO:1902110; P:positive regulation of mitochondrial membrane permeability involved in apoptotic process; ISO:RGD.
DR   InterPro; IPR010736; SHIPPO-rpt.
DR   Pfam; PF07004; SHIPPO-rpt; 3.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..341
FT                   /note="O(6)-methylguanine-induced apoptosis 2"
FT                   /id="PRO_0000305172"
FT   REPEAT          73..80
FT                   /note="STPGR 1"
FT   REPEAT          115..123
FT                   /note="STPGR 2"
FT   REPEAT          154..160
FT                   /note="STPGR 3"
FT   REPEAT          194..213
FT                   /note="STPGR 4"
FT   REPEAT          232..254
FT                   /note="STPGR 5"
FT   REPEAT          273..284
FT                   /note="STPGR 6"
FT   REPEAT          313..323
FT                   /note="STPGR 7"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         78
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5TH74"
SQ   SEQUENCE   341 AA;  37534 MW;  E7650E3F9B39BFBE CRC64;
     MSQKFANTGS FIEREDLGKP NKGVDRVQKG FTAAYPTQSS IPYRHRRSVI PESEKRGFNS
     QARRFYSKKD DIPGPGFYNV IHQSLVFNSV SLSKRGTCTF PSTCARLGPI ISKYPAANAY
     TIRSELASKK DFSNSCSSMF QLPTFIKVVK SETPAPNHYN ASISICKQRN NVCARAGFLS
     KTPRGFVPSS EPGGPAPGHY DVNESLVRES PKVLVSCFKS KTGRGLKPTS TGPGPGYYNP
     NDQTKILRKS HLPKTTLLNF SAQPLPLPEK PPLPGPGQYE IVNYQGPPKH FISTASFVSN
     TSRWPVKSSK PTLPGPASYK PEIPGKQSFL YNEDNKWIPA V