STPG3_HUMAN
ID STPG3_HUMAN Reviewed; 386 AA.
AC Q8N7X2; A2RU24; B7ZM72; B7ZM76; Q8NEA3;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Protein STPG3;
DE AltName: Full=Sperm-tail PG-rich repeat-containing protein 3 {ECO:0000312|HGNC:HGNC:37285};
GN Name=STPG3 {ECO:0000312|HGNC:HGNC:37285}; Synonyms=C9orf173;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=2;
CC IsoId=Q8N7X2-2; Sequence=Displayed;
CC Name=1;
CC IsoId=Q8N7X2-1; Sequence=VSP_059448;
CC Name=3;
CC IsoId=Q8N7X2-3; Sequence=VSP_059447;
CC Name=4;
CC IsoId=Q8N7X2-4; Sequence=VSP_059449;
CC -!- MISCELLANEOUS: [Isoform 1]: Dubious isoform produced through aberrant
CC splice sites. {ECO:0000305}.
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DR EMBL; AK097565; BAC05104.1; -; mRNA.
DR EMBL; BC033939; AAH33939.2; -; mRNA.
DR EMBL; BX255925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC132726; AAI32727.1; -; mRNA.
DR EMBL; BC144308; AAI44309.1; -; mRNA.
DR EMBL; BC144314; AAI44315.1; -; mRNA.
DR CCDS; CCDS48065.1; -. [Q8N7X2-4]
DR CCDS; CCDS59156.1; -. [Q8N7X2-2]
DR CCDS; CCDS75940.1; -. [Q8N7X2-3]
DR RefSeq; NP_001004353.2; NM_001004353.3. [Q8N7X2-4]
DR RefSeq; NP_001243628.1; NM_001256699.1. [Q8N7X2-2]
DR RefSeq; NP_001243629.1; NM_001256700.1. [Q8N7X2-3]
DR RefSeq; NP_001243630.1; NM_001256701.1.
DR RefSeq; XP_006717176.1; XM_006717113.2. [Q8N7X2-2]
DR AlphaFoldDB; Q8N7X2; -.
DR SMR; Q8N7X2; -.
DR BioGRID; 137505; 14.
DR IntAct; Q8N7X2; 4.
DR STRING; 9606.ENSP00000373583; -.
DR iPTMnet; Q8N7X2; -.
DR PhosphoSitePlus; Q8N7X2; -.
DR BioMuta; STPG3; -.
DR DMDM; 74729306; -.
DR EPD; Q8N7X2; -.
DR MassIVE; Q8N7X2; -.
DR PaxDb; Q8N7X2; -.
DR PeptideAtlas; Q8N7X2; -.
DR PRIDE; Q8N7X2; -.
DR Antibodypedia; 48969; 51 antibodies from 10 providers.
DR DNASU; 441476; -.
DR Ensembl; ENST00000388931.7; ENSP00000373583.3; ENSG00000197768.11. [Q8N7X2-2]
DR Ensembl; ENST00000412566.6; ENSP00000391218.1; ENSG00000197768.11. [Q8N7X2-4]
DR Ensembl; ENST00000611378.4; ENSP00000477998.1; ENSG00000197768.11. [Q8N7X2-3]
DR GeneID; 441476; -.
DR KEGG; hsa:441476; -.
DR MANE-Select; ENST00000412566.6; ENSP00000391218.1; NM_001004353.4; NP_001004353.2. [Q8N7X2-4]
DR UCSC; uc004cmj.2; human. [Q8N7X2-2]
DR CTD; 441476; -.
DR GeneCards; STPG3; -.
DR HGNC; HGNC:37285; STPG3.
DR HPA; ENSG00000197768; Tissue enriched (testis).
DR neXtProt; NX_Q8N7X2; -.
DR OpenTargets; ENSG00000197768; -.
DR PharmGKB; PA165585550; -.
DR VEuPathDB; HostDB:ENSG00000197768; -.
DR eggNOG; ENOG502S213; Eukaryota.
DR GeneTree; ENSGT00390000009524; -.
DR HOGENOM; CLU_772824_0_0_1; -.
DR InParanoid; Q8N7X2; -.
DR OMA; FTQKTDF; -.
DR OrthoDB; 1459440at2759; -.
DR PhylomeDB; Q8N7X2; -.
DR TreeFam; TF329447; -.
DR PathwayCommons; Q8N7X2; -.
DR SignaLink; Q8N7X2; -.
DR BioGRID-ORCS; 441476; 40 hits in 998 CRISPR screens.
DR GenomeRNAi; 441476; -.
DR Pharos; Q8N7X2; Tdark.
DR PRO; PR:Q8N7X2; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q8N7X2; protein.
DR Bgee; ENSG00000197768; Expressed in left testis and 94 other tissues.
DR ExpressionAtlas; Q8N7X2; baseline and differential.
DR Genevisible; Q8N7X2; HS.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..386
FT /note="Protein STPG3"
FT /id="PRO_0000325615"
FT REGION 105..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 165..219
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15164053"
FT /id="VSP_059447"
FT VAR_SEQ 266
FT /note="S -> WLPA (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_059448"
FT VAR_SEQ 267..386
FT /note="FSFGSPNPWPSRLPRGGLQLTLPFGAWRGHPGCTQTQAPRHRPLLHALEPAG
FT HNLLGPATEWNHGLPRGFPRPPLGLGAPAWPSDPLGTPMHPSGWPTLLWAVDKAGPAWI
FT PHLPISPLH -> RTPGPAAYHVEDCNSRFPSAPGVVIQGVRRPKRHDTGPFCTL (in
FT isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_059449"
FT VARIANT 126
FT /note="S -> G (in dbSNP:rs28657439)"
FT /id="VAR_039898"
SQ SEQUENCE 386 AA; 42496 MW; 62EBD0C134F8449D CRC64;
MMNSDQKAVK FLANFYINGG KHWTHGHLRQ TQPEPTQPKA SVLLLGPEPG MAWDETQPPK
MKEIPVGLRL QTGTPQESLP TYTQTLRELL LEQRPLITAD LEVPSPTRYQ VPSPSVRESS
PHPHYSIGCK HQGREGGGRR AWQTLWFQSE SPFTQKADFD QEQKWPSPAH YQLLSRPAFP
AFSFRGCHSA SKTPEGHTHL GLPGARGLGL RVQPQSLLQA SLQAPGKRCP GPNTYNILPG
SRLQSPRSPA FSMSRSPAFT SWLSTSFSFG SPNPWPSRLP RGGLQLTLPF GAWRGHPGCT
QTQAPRHRPL LHALEPAGHN LLGPATEWNH GLPRGFPRPP LGLGAPAWPS DPLGTPMHPS
GWPTLLWAVD KAGPAWIPHL PISPLH
