STPG4_HUMAN
ID STPG4_HUMAN Reviewed; 248 AA.
AC Q8N801; H7C2Z2;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2013, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Protein STPG4 {ECO:0000305};
DE AltName: Full=Gonad-specific expression gene protein {ECO:0000250|UniProtKB:Q9DAG5};
DE Short=GSE {ECO:0000250|UniProtKB:Q9DAG5};
DE AltName: Full=Sperm-tail PG-rich repeat-containing protein 4 {ECO:0000312|HGNC:HGNC:26850};
GN Name=STPG4 {ECO:0000312|HGNC:HGNC:26850};
GN Synonyms=C2orf61 {ECO:0000312|HGNC:HGNC:26850};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-248 (ISOFORM 1).
RC TISSUE=Testis;
RA Arakawa T., Carninci P., Fukuda S., Hasegawa A., Hayashida K., Hori F.,
RA Kai C., Kawai J., Kojima M., Murata M., Nakamura M., Nishiyori H.,
RA Nomura K., Ohno M., Sasaki D., Shibazaki E., Tagami M., Tagami Y.,
RA Hayashizaki Y.;
RL Submitted (MAY-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Maternal factor that plays a role in epigenetic chromatin
CC reprogramming during early development of the zygote. Involved in the
CC regulation of gametic DNA demethylation by inducing the conversion of
CC the modified genomic base 5-methylcytosine (5mC) into 5-
CC hydroxymethylcytosine (5hmC). {ECO:0000250|UniProtKB:Q9DAG5}.
CC -!- SUBUNIT: Interacts with histone H3. Interacts with histone H4.
CC {ECO:0000250|UniProtKB:Q9DAG5}.
CC -!- INTERACTION:
CC Q8N801-2; Q53EP0-3: FNDC3B; NbExp=3; IntAct=EBI-12871202, EBI-10242151;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9DAG5}. Nucleus
CC {ECO:0000250|UniProtKB:Q9DAG5}. Note=Localizes in female and male
CC zygote pronucleus. Associates preferentially with the paternal
CC chromatin during zygote development. {ECO:0000250|UniProtKB:Q9DAG5}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N801-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N801-2; Sequence=VSP_047926;
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DR EMBL; AK097491; BAC05075.1; -; mRNA.
DR EMBL; AC073283; AAY24084.1; -; Genomic_DNA.
DR EMBL; CH471053; EAX00224.1; -; Genomic_DNA.
DR EMBL; CH471053; EAX00225.1; -; Genomic_DNA.
DR EMBL; HY239491; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS1831.1; -. [Q8N801-2]
DR CCDS; CCDS54356.1; -. [Q8N801-1]
DR RefSeq; NP_001157033.1; NM_001163561.1. [Q8N801-1]
DR RefSeq; NP_775920.1; NM_173649.2. [Q8N801-2]
DR AlphaFoldDB; Q8N801; -.
DR BioGRID; 130008; 3.
DR IntAct; Q8N801; 2.
DR STRING; 9606.ENSP00000408527; -.
DR iPTMnet; Q8N801; -.
DR PhosphoSitePlus; Q8N801; -.
DR BioMuta; STPG4; -.
DR DMDM; 544584734; -.
DR MassIVE; Q8N801; -.
DR PaxDb; Q8N801; -.
DR PeptideAtlas; Q8N801; -.
DR PRIDE; Q8N801; -.
DR ProteomicsDB; 45153; -.
DR ProteomicsDB; 72352; -. [Q8N801-1]
DR TopDownProteomics; Q8N801-2; -. [Q8N801-2]
DR Antibodypedia; 62229; 37 antibodies from 7 providers.
DR DNASU; 285051; -.
DR Ensembl; ENST00000294947.2; ENSP00000294947.2; ENSG00000239605.11. [Q8N801-2]
DR Ensembl; ENST00000445927.7; ENSP00000408527.2; ENSG00000239605.11. [Q8N801-1]
DR GeneID; 285051; -.
DR KEGG; hsa:285051; -.
DR MANE-Select; ENST00000445927.7; ENSP00000408527.2; NM_001163561.2; NP_001157033.1.
DR UCSC; uc002rvs.3; human. [Q8N801-1]
DR CTD; 285051; -.
DR DisGeNET; 285051; -.
DR GeneCards; STPG4; -.
DR HGNC; HGNC:26850; STPG4.
DR HPA; ENSG00000239605; Tissue enriched (testis).
DR neXtProt; NX_Q8N801; -.
DR OpenTargets; ENSG00000239605; -.
DR PharmGKB; PA162379319; -.
DR VEuPathDB; HostDB:ENSG00000239605; -.
DR eggNOG; ENOG502S008; Eukaryota.
DR GeneTree; ENSGT00390000008095; -.
DR HOGENOM; CLU_085743_0_0_1; -.
DR InParanoid; Q8N801; -.
DR OMA; SCFQSKV; -.
DR OrthoDB; 1292301at2759; -.
DR PhylomeDB; Q8N801; -.
DR TreeFam; TF329156; -.
DR PathwayCommons; Q8N801; -.
DR SignaLink; Q8N801; -.
DR BioGRID-ORCS; 285051; 9 hits in 1031 CRISPR screens.
DR ChiTaRS; C2orf61; human.
DR GenomeRNAi; 285051; -.
DR Pharos; Q8N801; Tdark.
DR PRO; PR:Q8N801; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8N801; protein.
DR Bgee; ENSG00000239605; Expressed in left testis and 92 other tissues.
DR ExpressionAtlas; Q8N801; baseline and differential.
DR Genevisible; Q8N801; HS.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0001939; C:female pronucleus; ISS:UniProtKB.
DR GO; GO:0042585; C:germinal vesicle; ISS:UniProtKB.
DR GO; GO:0001673; C:male germ cell nucleus; IEA:Ensembl.
DR GO; GO:0001940; C:male pronucleus; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0090116; P:C-5 methylation of cytosine; IEA:Ensembl.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0044727; P:DNA demethylation of male pronucleus; ISS:UniProtKB.
DR GO; GO:1901537; P:positive regulation of DNA demethylation; ISS:UniProtKB.
DR InterPro; IPR010736; SHIPPO-rpt.
DR InterPro; IPR039345; STPG4.
DR PANTHER; PTHR35678; PTHR35678; 1.
DR Pfam; PF07004; SHIPPO-rpt; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Chromatin regulator; Cytoplasm;
KW Developmental protein; Nucleus; Reference proteome.
FT CHAIN 1..248
FT /note="Protein STPG4"
FT /id="PRO_0000311684"
FT VAR_SEQ 174..248
FT /note="HEGPGPGHYNVKMPPTSSVTSCFQSRVPRFLPSCSKTPGPGAYTTLRQFPKQ
FT SPTIAKMGQEHSLFFNNNNWLLK -> VSIM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_047926"
FT VARIANT 17
FT /note="L -> M (in dbSNP:rs815804)"
FT /id="VAR_050715"
FT VARIANT 31
FT /note="Q -> R (in dbSNP:rs17036300)"
FT /id="VAR_050716"
SQ SEQUENCE 248 AA; 27807 MW; F485CCA6A7BA3417 CRC64;
MDQPAVATAS TSIREDLVGG ESFITASKPA QKTSSFEREG WWRIALTDTP IPGTYHLKTF
IEESLLNPVI ATYNFKNEGR KKPPLVQRNN PVLNDLPQYM PPDFLDLLKK QVATYSFKDK
PRPSPSTLVD KDQSLQLSPG QYNVLPAPVP KYASRSCVFR STVQRFPTTY FIPHEGPGPG
HYNVKMPPTS SVTSCFQSRV PRFLPSCSKT PGPGAYTTLR QFPKQSPTIA KMGQEHSLFF
NNNNWLLK
