ID   STP_SHV2C               Reviewed;         102 AA.
AC   P22576;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   29-SEP-2021, entry version 72.
DE   RecName: Full=Saimiri transformation-associated protein;
DE   AltName: Full=Collagen-like protein;
DE   AltName: Full=stpC;
OS   Saimiriine herpesvirus 2 (strain 488) (SaHV-2) (Herpesvirus saimiri).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=10384;
OH   NCBI_TaxID=9521; Saimiri sciureus (Common squirrel monkey).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2161148; DOI=10.1016/0042-6822(90)90020-r;
RA   Biesinger B., Trimble J.J., Desrosiers R.C., Fleckenstein B.;
RT   "The divergence between two oncogenic Herpesvirus saimiri strains in a
RT   genomic region related to the transforming phenotype.";
RL   Virology 176:505-514(1990).
RN   [2]
RP   FUNCTION.
RX   PubMed=11145913; DOI=10.1006/viro.2000.0714;
RA   Merlo J.J., Tsygankov A.Y.;
RT   "Herpesvirus saimiri oncoproteins Tip and StpC synergistically stimulate
RT   NF-kappaB activity and interleukin-2 gene expression.";
RL   Virology 279:325-338(2001).
RN   [3]
RP   REVIEW.
RX   PubMed=15389624; DOI=10.1002/jcp.20225;
RA   Tsygankov A.Y.;
RT   "Cell transformation by Herpesvirus saimiri.";
RL   J. Cell. Physiol. 203:305-318(2005).
CC   -!- FUNCTION: Acts synergistically with Tip to stimulate NF-kappa-B
CC       activity and interleukin-2 gene expression by binding to host TRAF
CC       proteins. Activation of NF-kappa-B protects lymphocytes from apoptosis,
CC       thereby facilitating viral induced cell transformation.
CC       {ECO:0000269|PubMed:11145913}.
CC   -!- SUBUNIT: Binds to host RAS and TRAF2.
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Saimiriine herpesvirus 2 transforms T-lymphocytes,
CC       including human, to continuous growth in vitro. Two viral proteins, Tip
CC       and StpC, are essential for this function. The virus induced
CC       transforming activation is used as an important tool of T-cell biology,
CC       including HIV replication.
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DR   EMBL; M55264; AAA72929.1; -; Genomic_DNA.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR017095; StpC.
DR   Pfam; PF01391; Collagen; 1.
DR   PIRSF; PIRSF037035; Transforming_StpC; 1.
PE   4: Predicted;
KW   Collagen; Host membrane; Host-virus interaction; Membrane; Oncogene;
KW   Repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..102
FT                   /note="Saimiri transformation-associated protein"
FT                   /id="PRO_0000116198"
FT   TOPO_DOM        1..72
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        94..102
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          15..71
FT                   /note="Collagen-like"
FT   REGION          1..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..71
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   102 AA;  9893 MW;  4C2CD389E78A03C2 CRC64;
     MASEPNLRYP IEETGDRGPP GPPGPPGPQG PPGPQGPPGP QGPPGPPGPP GPPGPPGPPG
     PPGPPGPPGL PGLFVTNLLL GIIVLLLLII VALLLVSKLV VN