STR1_SCHPO
ID STR1_SCHPO Reviewed; 612 AA.
AC O74395;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Siderophore iron transporter 1;
GN Name=str1; ORFNames=SPBC4F6.09;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION.
RX PubMed=12888492; DOI=10.1093/nar/gkg647;
RA Pelletier B., Beaudoin J., Philpott C.C., Labbe S.;
RT "Fep1 represses expression of the fission yeast Schizosaccharomyces pombe
RT siderophore-iron transport system.";
RL Nucleic Acids Res. 31:4332-4344(2003).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5; SER-21; SER-22; SER-36 AND
RP SER-41, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Involved in the transport of siderophore iron and so has a
CC role in iron homeostasis. {ECO:0000269|PubMed:12888492}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; CU329671; CAA20729.1; -; Genomic_DNA.
DR PIR; T40506; T40506.
DR RefSeq; NP_596109.1; NM_001022026.2.
DR AlphaFoldDB; O74395; -.
DR BioGRID; 276750; 1.
DR STRING; 4896.SPBC4F6.09.1; -.
DR TCDB; 2.A.1.16.6; the major facilitator superfamily (mfs).
DR iPTMnet; O74395; -.
DR MaxQB; O74395; -.
DR PaxDb; O74395; -.
DR PRIDE; O74395; -.
DR EnsemblFungi; SPBC4F6.09.1; SPBC4F6.09.1:pep; SPBC4F6.09.
DR GeneID; 2540217; -.
DR KEGG; spo:SPBC4F6.09; -.
DR PomBase; SPBC4F6.09; str1.
DR VEuPathDB; FungiDB:SPBC4F6.09; -.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_012970_2_0_1; -.
DR InParanoid; O74395; -.
DR OMA; LMREPTI; -.
DR PhylomeDB; O74395; -.
DR PRO; PR:O74395; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015343; F:siderophore transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0044718; P:siderophore transmembrane transport; IMP:PomBase.
DR GO; GO:0033214; P:siderophore-dependent iron import into cell; TAS:PomBase.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR010573; MFS_Str1/Tri12-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF06609; TRI12; 1.
DR SUPFAM; SSF103473; SSF103473; 2.
DR PROSITE; PS50850; MFS; 1.
PE 1: Evidence at protein level;
KW Ion transport; Iron; Iron transport; Membrane; Phosphoprotein;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..612
FT /note="Siderophore iron transporter 1"
FT /id="PRO_0000084879"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 299..319
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 434..453
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 464..484
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 495..515
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 573..593
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 5
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 21
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 22
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 36
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 41
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 612 AA; 68156 MW; DD7BE0D143D70C6E CRC64;
MRLKSFSTTL DTLRRRFNDS SSEEDKLEKN IQDETSIKEV SLQDAKQSDE KGVEEKVFND
ESFSIDVAPK PEDELSGIVK ARYLTEHSSR ISFYICYFSI FLLFFAISFQ AECYYSLTAY
ATSAFAGHSL LSTIAVANNI ISAAIKPPLA RLSDVFGRLE AFLFSLLLYL VGLILMAAST
NVQTYAGGSV LYNAGYTGVE LIMTIFMADT SSMANRSLVL GISYLPFVVT IWIGPRVAQE
FYMHSTWRWG IAVWTILIPA CSIPFLAVYS YYQFRAWREG ALKGTLTINP VELFKKLDII
GLILMTAGLA LVLLSISLAS YDTGKWSDAK FIVMIIIGGL CLIAFVLYEI FVASFPALPF
RLMREPTIGA CCAMSFLFYI TFYCWDNYYY SFLQVVHYTS ITAAGYISYT YSFTSCATGF
FLGILIRLTK RYKWYFVASI PVYILGQGLM IRYRGEQYNW GYQIMPQIIV GIGGGVIANL
LTVAVQTVVS TENFAIVTAL VSTVTPIGGA VGSAISGAIW NSVMPKRLEK NLPSDLKDQA
YTIFESLTVQ LSYTRGTDAR NAIILSYSEV QKILTSVATG FAGAMIFPVW FVANPRLSTV
KTHIFDSKES KV
