ID   STR2_SCHPO              Reviewed;         597 AA.
AC   O94607;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Siderophore iron transporter 2;
GN   Name=str2; ORFNames=SPCC61.01c, SPCC622.20c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   FUNCTION.
RX   PubMed=12888492; DOI=10.1093/nar/gkg647;
RA   Pelletier B., Beaudoin J., Philpott C.C., Labbe S.;
RT   "Fep1 represses expression of the fission yeast Schizosaccharomyces pombe
RT   siderophore-iron transport system.";
RL   Nucleic Acids Res. 31:4332-4344(2003).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-46, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- FUNCTION: Involved in the transport of siderophore iron and so has a
CC       role in iron homeostasis. {ECO:0000269|PubMed:12888492}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; CU329672; CAA21876.1; -; Genomic_DNA.
DR   PIR; T41501; T41501.
DR   RefSeq; NP_588192.1; NM_001023182.2.
DR   AlphaFoldDB; O94607; -.
DR   STRING; 4896.SPCC61.01c.1; -.
DR   TCDB; 2.A.1.16.5; the major facilitator superfamily (mfs).
DR   iPTMnet; O94607; -.
DR   SwissPalm; O94607; -.
DR   PaxDb; O94607; -.
DR   PRIDE; O94607; -.
DR   EnsemblFungi; SPCC61.01c.1; SPCC61.01c.1:pep; SPCC61.01c.
DR   GeneID; 2539559; -.
DR   KEGG; spo:SPCC61.01c; -.
DR   PomBase; SPCC61.01c; str2.
DR   VEuPathDB; FungiDB:SPCC61.01c; -.
DR   eggNOG; KOG0254; Eukaryota.
DR   HOGENOM; CLU_012970_2_0_1; -.
DR   InParanoid; O94607; -.
DR   OMA; CIAVSIY; -.
DR   PhylomeDB; O94607; -.
DR   PRO; PR:O94607; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; HDA:PomBase.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0015343; F:siderophore transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   GO; GO:0044718; P:siderophore transmembrane transport; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   1: Evidence at protein level;
KW   Ion transport; Iron; Iron transport; Membrane; Phosphoprotein;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..597
FT                   /note="Siderophore iron transporter 2"
FT                   /id="PRO_0000084880"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        225..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        390..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        419..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        448..468
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        485..505
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        558..578
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         46
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   597 AA;  66122 MW;  336E91E888ED8BA5 CRC64;
     MTENYGSMEH RKKSFRNNEN LEQQFHPLRE ELDNAGPIND RTSELSLEGV SKAEAIASTW
     SKRSIIVAYL GLYLLSFASS LEQQTTYSLQ RYATSNFSAH SNLATINLVG NILLAVVRAP
     MVKAADVFGR SESLSLALGM TVLGYLSLAF SRNIQMFTVA YILYICGQTG LGLLSQLIIA
     DTSSLLNRGI LSAIPELPYL ATVWIGPVLA QAFHPEKNYG WRLGYGIWAF ILPTVSLPLL
     ASLFLNQRKA KAAGLYREHH NLINHSTPEK LRLFYLFWQE LDGLGIVLFV SGFTLLLLPF
     SHSSQVVSPD STILTLFTIT LSIALLVTLC FYDVKYARYP VFALKSLKDR TILGSCVLIF
     TYFMSYYIFS NFLTSFLQVS YGLSIDMSSL TLNVFVFSMT TTAILSGFLM KRFGRFKMLL
     MISVPMYVLG ILGIILFGIN DNHYTRPLVL VLILAGMGGG LLTLSAQIAV QSVSSHAKLG
     MNLTLYLTFS SVGGAFGSAI AGGVWSKRLS SRLLHDLKDH LPVPEIESIF RDLRTALSYP
     QGTQIRNIIN VAYTATEKDL FHISLVASLF MFAGLVIIRD VPLSTENHDT AVETPSE