STRA8_HUMAN
ID STRA8_HUMAN Reviewed; 330 AA.
AC Q7Z7C7;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Stimulated by retinoic acid gene 8 protein homolog {ECO:0000305};
GN Name=STRA8 {ECO:0000312|HGNC:HGNC:30653};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAP47163.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=12489526; DOI=10.1023/a:1020963919596;
RA Miyamoto T., Sengoku K., Takuma N., Hasuike S., Hayashi H., Yamauchi T.,
RA Yamashita T., Ishikawa M.;
RT "Isolation and expression analysis of the testis-specific gene, STRA8,
RT stimulated by retinoic acid gene 8.";
RL J. Assist. Reprod. Genet. 19:531-535(2002).
RN [2] {ECO:0000312|EMBL:EAL24061.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [3] {ECO:0000312|EMBL:EAW83846.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=26742488; DOI=10.1038/ncomms10324;
RA Abby E., Tourpin S., Ribeiro J., Daniel K., Messiaen S., Moison D.,
RA Guerquin J., Gaillard J.C., Armengaud J., Langa F., Toth A., Martini E.,
RA Livera G.;
RT "Implementation of meiosis prophase I programme requires a conserved
RT retinoid-independent stabilizer of meiotic transcripts.";
RL Nat. Commun. 7:10324-10324(2016).
RN [5]
RP VARIANT ILE-25.
RX PubMed=28718531; DOI=10.1111/andr.12378;
RA Nakamura S., Miyado M., Saito K., Katsumi M., Nakamura A., Kobori Y.,
RA Tanaka Y., Ishikawa H., Yoshida A., Okada H., Hata K., Nakabayashi K.,
RA Okamura K., Ogata H., Matsubara Y., Ogata T., Nakai H., Fukami M.;
RT "Next-generation sequencing for patients with non-obstructive azoospermia:
RT implications for significant roles of monogenic/oligogenic mutations.";
RL Andrology 5:824-831(2017).
CC -!- FUNCTION: Meiosis-inducer required for the transition into meiosis for
CC both female and male germ cells. In female germ cells, acts downstream
CC of ZGLP1 as a key effector of the meiotic program: required for
CC premeiotic DNA replication and subsequent events in meiotic prophase.
CC During spermatogenesis, next to its role in meiotic initiation,
CC promotes (but is not required for) spermatogonial differentiation. In
CC complex with MEIOSIN, directly activates the transcription of a subset
CC of critical meiotic genes playing a central role in cell-cycle
CC switching from mitosis to meiosis. {ECO:0000250|UniProtKB:P70278}.
CC -!- SUBUNIT: Interacts with XPO1. Interacts with MEIOSIN (By similarity).
CC {ECO:0000250|UniProtKB:P70278}.
CC -!- INTERACTION:
CC Q7Z7C7; X5D778: ANKRD11; NbExp=3; IntAct=EBI-12036261, EBI-17183751;
CC Q7Z7C7; P78358: CTAG1B; NbExp=3; IntAct=EBI-12036261, EBI-1188472;
CC Q7Z7C7; Q9GZU7: CTDSP1; NbExp=3; IntAct=EBI-12036261, EBI-751587;
CC Q7Z7C7; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12036261, EBI-16439278;
CC Q7Z7C7; P78424: POU6F2; NbExp=3; IntAct=EBI-12036261, EBI-12029004;
CC Q7Z7C7; Q14140: SERTAD2; NbExp=3; IntAct=EBI-12036261, EBI-2822051;
CC Q7Z7C7; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-12036261, EBI-1105213;
CC Q7Z7C7; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-12036261, EBI-12030590;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P70278}. Nucleus
CC {ECO:0000250|UniProtKB:P70278}. Note=Shuttles between nucleus and
CC cytoplasm. Nuclear export is XPO1-dependent.
CC {ECO:0000250|UniProtKB:P70278}.
CC -!- TISSUE SPECIFICITY: Expressed specifically in testis and fetal ovaries.
CC {ECO:0000269|PubMed:12489526, ECO:0000269|PubMed:26742488}.
CC -!- DEVELOPMENTAL STAGE: Expression detected in fetal ovaries between wpf
CC (weeks post-fertilization) 11 and 27; expression peaks at wpf 14.5 and
CC is decreasing afterwards. {ECO:0000269|PubMed:26742488}.
CC -!- PTM: Phosphorylated. {ECO:0000250|UniProtKB:P70278}.
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DR EMBL; AF513502; AAP47163.1; -; mRNA.
DR EMBL; CH236950; EAL24061.1; -; Genomic_DNA.
DR EMBL; CH471070; EAW83846.1; -; Genomic_DNA.
DR RefSeq; NP_872295.1; NM_182489.1.
DR AlphaFoldDB; Q7Z7C7; -.
DR SMR; Q7Z7C7; -.
DR BioGRID; 131396; 16.
DR IntAct; Q7Z7C7; 8.
DR STRING; 9606.ENSP00000275764; -.
DR iPTMnet; Q7Z7C7; -.
DR PhosphoSitePlus; Q7Z7C7; -.
DR BioMuta; STRA8; -.
DR DMDM; 74713759; -.
DR MassIVE; Q7Z7C7; -.
DR PaxDb; Q7Z7C7; -.
DR PeptideAtlas; Q7Z7C7; -.
DR PRIDE; Q7Z7C7; -.
DR ProteomicsDB; 69514; -.
DR Antibodypedia; 53744; 198 antibodies from 25 providers.
DR DNASU; 346673; -.
DR Ensembl; ENST00000275764.3; ENSP00000275764.3; ENSG00000146857.5.
DR GeneID; 346673; -.
DR KEGG; hsa:346673; -.
DR UCSC; uc011kpx.2; human.
DR CTD; 346673; -.
DR DisGeNET; 346673; -.
DR GeneCards; STRA8; -.
DR HGNC; HGNC:30653; STRA8.
DR HPA; ENSG00000146857; Tissue enriched (choroid).
DR MIM; 609987; gene.
DR neXtProt; NX_Q7Z7C7; -.
DR OpenTargets; ENSG00000146857; -.
DR PharmGKB; PA162405043; -.
DR VEuPathDB; HostDB:ENSG00000146857; -.
DR eggNOG; ENOG502RT8C; Eukaryota.
DR GeneTree; ENSGT00390000017181; -.
DR HOGENOM; CLU_049039_0_0_1; -.
DR InParanoid; Q7Z7C7; -.
DR OrthoDB; 879443at2759; -.
DR PhylomeDB; Q7Z7C7; -.
DR TreeFam; TF335594; -.
DR PathwayCommons; Q7Z7C7; -.
DR SignaLink; Q7Z7C7; -.
DR BioGRID-ORCS; 346673; 8 hits in 1074 CRISPR screens.
DR GenomeRNAi; 346673; -.
DR Pharos; Q7Z7C7; Tbio.
DR PRO; PR:Q7Z7C7; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q7Z7C7; protein.
DR Bgee; ENSG00000146857; Expressed in sural nerve and 39 other tissues.
DR ExpressionAtlas; Q7Z7C7; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0090427; P:activation of meiosis; ISS:UniProtKB.
DR GO; GO:0071300; P:cellular response to retinoic acid; ISS:UniProtKB.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0051321; P:meiotic cell cycle; ISS:UniProtKB.
DR GO; GO:0048477; P:oogenesis; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR033537; Stra8.
DR PANTHER; PTHR35254; PTHR35254; 2.
DR SUPFAM; SSF47459; SSF47459; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Differentiation; Disease variant; DNA replication;
KW Meiosis; Nucleus; Oogenesis; Phosphoprotein; Reference proteome;
KW Spermatogenesis; Transcription; Transcription regulation.
FT CHAIN 1..330
FT /note="Stimulated by retinoic acid gene 8 protein homolog"
FT /id="PRO_0000318114"
FT COILED 88..112
FT /evidence="ECO:0000255"
FT MOTIF 50..55
FT /note="Nuclear localization signal (NLS)"
FT /evidence="ECO:0000250|UniProtKB:P70278"
FT VARIANT 25
FT /note="T -> I (found in patients with non-obstructive
FT azoospermia; unknown pathological significance)"
FT /evidence="ECO:0000269|PubMed:28718531"
FT /id="VAR_081144"
SQ SEQUENCE 330 AA; 36908 MW; 35DA813FADAA435C CRC64;
MGKIDVDKIL FFNQEIRLWQ LIMATPEENS NPHDRATPQL PAQLQELEHR VARRRLSQAR
HRATLAALFN NLRKTVYSQS DLIASKWQVL NKAKSHIPEL EQTLDNLLKL KASFNLEDGH
ASSLEEVKKE YASMYSGNDS FPQNGSSPWY LNFYKQTMDL LTGSGIITPQ EAALPIVSAA
ISHLWQNLSE ERKASLRQAW AQKHRGPATL AEACREPACA EGSVKDSGVD SQGASCSLVS
TPEEILFEDA FDVASFLDKS EVPSTSSSSS VLASCNPENP EEKFQLYMQI INFFKGLSCA
NTQVKQEASF PVDEEMIMLQ CTETFDDEDL
