ID   STRAA_BOVIN             Reviewed;         373 AA.
AC   Q5E9J9;
DT   14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=STE20-related kinase adapter protein alpha;
DE            Short=STRAD alpha;
DE   AltName: Full=STE20-related adapter protein;
GN   Name=STRADA; Synonyms=LYK5 {ECO:0000312|EMBL:AAX08938.1}, STRAD;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000312|EMBL:AAX08938.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Pseudokinase which, in complex with CAB39/MO25
CC       (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates
CC       STK11/LKB1. Adopts a closed conformation typical of active protein
CC       kinases and binds STK11/LKB1 as a pseudosubstrate, promoting
CC       conformational change of STK11/LKB1 in an active conformation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of a trimeric complex composed of STK11/LKB1, STRAD
CC       (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta):
CC       the complex tethers STK11/LKB1 in the cytoplasm and stimulates its
CC       catalytic activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q7RTN6}.
CC   -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC       inactive. {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. STE20 subfamily. {ECO:0000305}.
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DR   EMBL; BT020921; AAX08938.1; -; mRNA.
DR   RefSeq; NP_001015603.1; NM_001015603.1.
DR   RefSeq; XP_005220926.1; XM_005220869.3.
DR   RefSeq; XP_005220927.1; XM_005220870.3.
DR   RefSeq; XP_005220929.1; XM_005220872.3.
DR   RefSeq; XP_005220930.1; XM_005220873.3.
DR   RefSeq; XP_015314359.1; XM_015458873.1.
DR   AlphaFoldDB; Q5E9J9; -.
DR   SMR; Q5E9J9; -.
DR   STRING; 9913.ENSBTAP00000051279; -.
DR   PaxDb; Q5E9J9; -.
DR   PRIDE; Q5E9J9; -.
DR   Ensembl; ENSBTAT00000000061; ENSBTAP00000000061; ENSBTAG00000000056.
DR   Ensembl; ENSBTAT00000079716; ENSBTAP00000065115; ENSBTAG00000000056.
DR   GeneID; 515024; -.
DR   KEGG; bta:515024; -.
DR   CTD; 92335; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000056; -.
DR   VGNC; VGNC:35418; STRADA.
DR   eggNOG; KOG0582; Eukaryota.
DR   GeneTree; ENSGT00940000158827; -.
DR   HOGENOM; CLU_000288_63_23_1; -.
DR   InParanoid; Q5E9J9; -.
DR   OMA; QRDPENR; -.
DR   OrthoDB; 995563at2759; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000000056; Expressed in spermatid and 105 other tissues.
DR   ExpressionAtlas; Q5E9J9; baseline.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:1902554; C:serine/threonine protein kinase complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0030295; F:protein kinase activator activity; ISS:UniProtKB.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0043539; F:protein serine/threonine kinase activator activity; IBA:GO_Central.
DR   GO; GO:0032147; P:activation of protein kinase activity; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006611; P:protein export from nucleus; ISS:UniProtKB.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..373
FT                   /note="STE20-related kinase adapter protein alpha"
FT                   /id="PRO_0000260034"
FT   DOMAIN          11..321
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   REGION          255..288
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        255..285
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         361
FT                   /note="Phosphothreonine; by LKB1"
FT                   /evidence="ECO:0000250|UniProtKB:Q7RTN6"
SQ   SEQUENCE   373 AA;  41582 MW;  A9BCB2460BDFC5C6 CRC64;
     MSSFLPEGGC YELLTVIGKG FEDLMTVNLA RYKPTGEYVT VRRINLEACS NEMVTFLQGE
     LHVSKLFSHP NILPYGATFI ADNELWVVTS FMAYGSAKDL ICTHFMDGMS ELAIAYILQG
     ALKALDYIHH MGYVHRSVKA SHVLISADGK VYLSGLRSNL SMISHGQRQR VVHDFPKYSI
     KVLPWLSPEV LQQNLQGYDA KSDIYSVGIT ACELANGHVP FKDMPATQML LEKLNGTVPC
     LLDTSTIPAE ELTMSTSRSA ANSGLSESLA PSTPRTSNGD SPSHPYHRTF SPHFHHFVEQ
     CLQRNPDMRP SASTLLNHSF FKQIKRRASE ALPELLRPVT PITTFEGRQS QDHSGIFGLV
     TNLEELEVDD WEF