ID   STRAA_CHICK             Reviewed;         389 AA.
AC   Q5ZK47;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=STE20-related kinase adapter protein alpha;
DE            Short=STRAD alpha;
DE   AltName: Full=STE20-related adapter protein;
GN   Name=STRADA; Synonyms=STRAD; ORFNames=RCJMB04_13d22;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1] {ECO:0000312|EMBL:CAG31896.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB {ECO:0000312|EMBL:CAG31896.1};
RC   TISSUE=Bursa of Fabricius {ECO:0000312|EMBL:CAG31896.1};
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
RN   [2] {ECO:0000305}
RP   TISSUE SPECIFICITY.
RX   PubMed=16343965; DOI=10.1016/j.cbpb.2005.10.009;
RA   Proszkowiec-Weglarz M., Richards M.P., Ramachandran R., McMurtry J.P.;
RT   "Characterization of the AMP-activated protein kinase pathway in
RT   chickens.";
RL   Comp. Biochem. Physiol. 143B:92-106(2006).
CC   -!- FUNCTION: Pseudokinase which, in complex with CAB39/MO25
CC       (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates
CC       STK11/LKB1. Adopts a closed conformation typical of active protein
CC       kinases and binds STK11/LKB1 as a pseudosubstrate, promoting
CC       conformational change of STK11/LKB1 in an active conformation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of a trimeric complex composed of STK11/LKB1, STRAD
CC       (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta):
CC       the complex tethers STK11/LKB1 in the cytoplasm and stimulates its
CC       catalytic activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q7RTN6}.
CC   -!- TISSUE SPECIFICITY: Expressed in brain, hypothalamus, heart and
CC       skeletal muscle. {ECO:0000269|PubMed:16343965}.
CC   -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC       inactive. {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. STE20 subfamily. {ECO:0000305}.
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DR   EMBL; AJ720237; CAG31896.1; -; mRNA.
DR   AlphaFoldDB; Q5ZK47; -.
DR   SMR; Q5ZK47; -.
DR   STRING; 9031.ENSGALP00000000765; -.
DR   PaxDb; Q5ZK47; -.
DR   VEuPathDB; HostDB:geneid_419957; -.
DR   eggNOG; KOG0582; Eukaryota.
DR   InParanoid; Q5ZK47; -.
DR   PhylomeDB; Q5ZK47; -.
DR   PRO; PR:Q5ZK47; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:1902554; C:serine/threonine protein kinase complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0030295; F:protein kinase activator activity; ISS:UniProtKB.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0043539; F:protein serine/threonine kinase activator activity; IBA:GO_Central.
DR   GO; GO:0032147; P:activation of protein kinase activity; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006611; P:protein export from nucleus; ISS:UniProtKB.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..389
FT                   /note="STE20-related kinase adapter protein alpha"
FT                   /id="PRO_0000260040"
FT   DOMAIN          11..321
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ   SEQUENCE   389 AA;  43397 MW;  BE31A675EC230AC6 CRC64;
     MSNFLPDSSC YELLTIIGRG FEDLMVVNLA RYKPSGEYVT VRRVNLEACT NEMVTFLQGE
     LHVSKLFNHP NIVPYKATFI ADNELWVVTS FMAYGSAKDL ICTHFMDGMS ELAIAYILQG
     VLKALDYIHH MGYVHRSVKA SHILISVDGK VYLSGLRSNL SMINHGQRLK VVHDFPKYSI
     KVLPWLSPEV LQQNLQGYDA KSDIYSIGIT ACELANGHVP FKDMPSTQML LEKLNGTVPC
     LLDTTTIPAD ELTMKTSRSS ANYGLGESTA VSNVRAANGE STLHPYLRTF SSCFHNFVGQ
     CLQRNPDFRP SAGALLNHPF FKQIKRRASE ALPELLRPVT PITNFEGTRP QDPSGILGWC
     QTWSSWMWMT GNSRKTKTAL GSGGAFWTL