ID   STRAA_MACFA             Reviewed;         394 AA.
AC   Q4R6X5;
DT   14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=STE20-related kinase adapter protein alpha;
DE            Short=STRAD alpha;
DE   AltName: Full=STE20-related adapter protein;
GN   Name=STRADA; Synonyms=STRAD; ORFNames=QtsA-16929;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1] {ECO:0000312|EMBL:BAE01149.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Pseudokinase which, in complex with CAB39/MO25
CC       (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates
CC       STK11/LKB1. Adopts a closed conformation typical of active protein
CC       kinases and binds STK11/LKB1 as a pseudosubstrate, promoting
CC       conformational change of STK11/LKB1 in an active conformation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of a trimeric complex composed of STK11/LKB1, STRAD
CC       (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta):
CC       the complex tethers STK11/LKB1 in the cytoplasm and stimulates its
CC       catalytic activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q7RTN6}.
CC   -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC       inactive. {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. STE20 subfamily. {ECO:0000305}.
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DR   EMBL; AB169055; BAE01149.1; -; mRNA.
DR   AlphaFoldDB; Q4R6X5; -.
DR   SMR; Q4R6X5; -.
DR   STRING; 9541.XP_005584703.1; -.
DR   eggNOG; KOG0582; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0030295; F:protein kinase activator activity; ISS:UniProtKB.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0032147; P:activation of protein kinase activity; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006611; P:protein export from nucleus; ISS:UniProtKB.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..394
FT                   /note="STE20-related kinase adapter protein alpha"
FT                   /id="PRO_0000260036"
FT   DOMAIN          32..342
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   REGION          273..306
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7RTN6"
FT   MOD_RES         9
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7RTN6"
FT   MOD_RES         292
FT                   /note="Phosphothreonine; by LKB1"
FT                   /evidence="ECO:0000250|UniProtKB:Q7RTN6"
FT   MOD_RES         382
FT                   /note="Phosphothreonine; by LKB1"
FT                   /evidence="ECO:0000250|UniProtKB:Q7RTN6"
SQ   SEQUENCE   394 AA;  43901 MW;  2932A355005979E0 CRC64;
     MSFLTNDASS ESIASFSKQE VMSSFLPEGG CYELLTVIGK GFEDLMTVNL ARYKPTGEYV
     TVRRINLGAC SNEMVTFLQG ELHVSKLFNH PNIVPYRATF IADNELWVVT SFMAYGSAKD
     LICTHFMDGM NELAIAYILQ GVLKALDYIH HMGYVHRSVK ASHILISLDG KVYLSGLRSN
     LSMISHGQRQ RVVHDFPKYS VKVLPWLSPE VLQQNLQGYD AKSDIYSVGI TACELANGHV
     PFKDMPATQM LLEKLNGTVP CLLDTSTIPA EELTMSPSRS VANSGLSDSL TTSTPRPSNG
     DSPSHPYHRT FSPYFHHFVE QCLQPNPDAR PSASTLLNHS FFKQIKRRAS EALPELLRPV
     TPITNFESSQ SQDHSGIFGL VTNLEELEVD DWEF