ID   STRAA_PONAB             Reviewed;         431 AA.
AC   Q5RBJ6;
DT   14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=STE20-related kinase adapter protein alpha;
DE            Short=STRAD alpha;
DE   AltName: Full=STE20-related adapter protein;
GN   Name=STRADA; Synonyms=STRAD;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1] {ECO:0000312|EMBL:CAH90864.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex {ECO:0000312|EMBL:CAH90864.1};
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Pseudokinase which, in complex with CAB39/MO25
CC       (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates
CC       STK11/LKB1. Adopts a closed conformation typical of active protein
CC       kinases and binds STK11/LKB1 as a pseudosubstrate, promoting
CC       conformational change of STK11/LKB1 in an active conformation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of a trimeric complex composed of STK11/LKB1, STRAD
CC       (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta):
CC       the complex tethers STK11/LKB1 in the cytoplasm and stimulates its
CC       catalytic activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q7RTN6}.
CC   -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC       inactive. {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. STE20 subfamily. {ECO:0000305}.
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DR   EMBL; CR858650; CAH90864.1; -; mRNA.
DR   RefSeq; NP_001125494.1; NM_001132022.1.
DR   AlphaFoldDB; Q5RBJ6; -.
DR   SMR; Q5RBJ6; -.
DR   STRING; 9601.ENSPPYP00000009579; -.
DR   GeneID; 100172403; -.
DR   KEGG; pon:100172403; -.
DR   CTD; 92335; -.
DR   eggNOG; KOG0582; Eukaryota.
DR   InParanoid; Q5RBJ6; -.
DR   OrthoDB; 995563at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0030295; F:protein kinase activator activity; ISS:UniProtKB.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0032147; P:activation of protein kinase activity; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006611; P:protein export from nucleus; ISS:UniProtKB.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..431
FT                   /note="STE20-related kinase adapter protein alpha"
FT                   /id="PRO_0000260038"
FT   DOMAIN          69..379
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   REGION          310..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        310..343
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7RTN6"
FT   MOD_RES         46
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7RTN6"
FT   MOD_RES         329
FT                   /note="Phosphothreonine; by LKB1"
FT                   /evidence="ECO:0000250|UniProtKB:Q7RTN6"
FT   MOD_RES         401
FT                   /note="Phosphothreonine; by LKB1"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         419
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7RTN6"
SQ   SEQUENCE   431 AA;  48333 MW;  1ED2CB33DC47A9D6 CRC64;
     MSFLVSKPER IRRWVSEKFI VEGLRDLELF GEQPPGDTRR KTNDASSESI APFSKQEVMG
     SFLPEGGCYE LLTVIGKGFE DLMTVNLARY KPTGEYVTVR RINLEACSNE MVTFLQGELH
     VSKLFNHPNI VPYRATFIAD NELWVVTSFM AYGSAKDLIC THFMDGMNEL AIAYILQGVL
     KALDYIHHMG YVHRSVKASH ILISVDGKVY LSGLRSNLSM ISHGQRQRVV HDFPKYSIKV
     LPWLSPEVLQ QNLQGYDAKS DIYSVGITAC ELANGHVPFK DMPATQTLLE KLNGTVPCLL
     DTSTIPAEEL TMSPSRSVAN SGLSDSLTTS TPRPSNGDSP SHPYHRTFSP HFHHFVEQCL
     QRNPDARPSA STLLNHSFFK QIKRRASEAL PELLRPVTPI TNFEGSQSQD HSGIFGLVTN
     LEELEVDDWE F