ID   STRAP_DICDI             Reviewed;         293 AA.
AC   Q54LT8;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Serine-threonine kinase receptor-associated protein;
DE   AltName: Full=WD40 repeat-containing protein strap;
GN   Name=strap; ORFNames=DDB_G0286457;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: The SMN complex catalyzes the assembly of small nuclear
CC       ribonucleoproteins (snRNPs), the building blocks of the spliceosome,
CC       and thereby plays an important role in the splicing of cellular pre-
CC       mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins
CC       SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in
CC       a heptameric protein ring on the Sm site of the small nuclear RNA to
CC       form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1,
CC       SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm
CC       complex by the chaperone CLNS1A that controls the assembly of the core
CC       snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm
CC       proteins from CLNS1A forming an intermediate. Binding of snRNA inside
CC       5Sm triggers eviction of the SMN complex, thereby allowing binding of
CC       SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP may play
CC       a role in the cellular distribution of the SMN complex (By similarity).
CC       {ECO:0000250|UniProtKB:Q9Y3F4}.
CC   -!- SUBUNIT: Part of the core SMN complex. {ECO:0000250|UniProtKB:Q9Y3F4}.
CC   -!- SIMILARITY: Belongs to the WD repeat STRAP family. {ECO:0000305}.
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DR   EMBL; AAFI02000085; EAL64253.1; -; Genomic_DNA.
DR   RefSeq; XP_637742.1; XM_632650.1.
DR   AlphaFoldDB; Q54LT8; -.
DR   SMR; Q54LT8; -.
DR   STRING; 44689.DDB0233062; -.
DR   PaxDb; Q54LT8; -.
DR   EnsemblProtists; EAL64253; EAL64253; DDB_G0286457.
DR   GeneID; 8625608; -.
DR   KEGG; ddi:DDB_G0286457; -.
DR   dictyBase; DDB_G0286457; strap.
DR   eggNOG; KOG0278; Eukaryota.
DR   HOGENOM; CLU_000288_57_6_1; -.
DR   InParanoid; Q54LT8; -.
DR   OMA; FQHNHIV; -.
DR   PhylomeDB; Q54LT8; -.
DR   PRO; PR:Q54LT8; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; ISS:dictyBase.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR013979; TIF_beta_prop-like.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF08662; eIF2A; 1.
DR   Pfam; PF00400; WD40; 2.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 7.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..293
FT                   /note="Serine-threonine kinase receptor-associated protein"
FT                   /id="PRO_0000371332"
FT   REPEAT          9..53
FT                   /note="WD 1"
FT   REPEAT          54..93
FT                   /note="WD 2"
FT   REPEAT          95..134
FT                   /note="WD 3"
FT   REPEAT          138..178
FT                   /note="WD 4"
FT   REPEAT          180..217
FT                   /note="WD 5"
FT   REPEAT          219..258
FT                   /note="WD 6"
FT   REPEAT          261..293
FT                   /note="WD 7"
SQ   SEQUENCE   293 AA;  32099 MW;  536A0C2BE2C03FF7 CRC64;
     MRQPLICSGH SRPVSDLSFS NENSDGSFIV SACLDGSPML RNGENGDWIG TFEGHKGAVW
     SSRFNSTASQ ALTASADYTV KLWDTLNGSE ILSIEHQSIV KTADFSNNNS RVVTGGSEKI
     LRIFDLERPN DPLLQISGHT NTIKTATWSV HNDDIVLSGG LDEVIRIWDL RSGTQVSLCA
     KSSITSMEFS KDRRFLVTTA GNEVTFWDAQ SFYPLKVYSL PFDVNCASLH PDNSKFIAGG
     SDFWVHVYDF STGNEIEVNK GHHGPVNCCR FSPDGASFAS GSLDGTIRLW KGM