ID   STRB2_STRGA             Reviewed;         319 AA.
AC   Q54264;
DT   11-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Putative inosamine-phosphate amidinotransferase 2;
DE            EC=2.1.4.2;
DE   AltName: Full=Aminocyclitol amidinotransferase;
DE            Short=ADT;
DE   AltName: Full=Inosamine-phosphate amidinotransferase II;
GN   Name=strB2;
OS   Streptomyces glaucescens.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 40716 / ETH 22794 / Tue 49;
RA   Mayer G., Piepersberg W.;
RL   Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: It is not obvious if strB2 participates in streptomycin
CC       biosynthesis as an inosamine-phosphate amidinotransferase. The
CC       nucleophilic cysteine which is the key residue for amidine transfer is
CC       not conserved but replaced by an arginine residue.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-
CC         guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine;
CC         Xref=Rhea:RHEA:13265, ChEBI:CHEBI:32682, ChEBI:CHEBI:46911,
CC         ChEBI:CHEBI:57656, ChEBI:CHEBI:58325; EC=2.1.4.2;
CC   -!- PATHWAY: Antibiotic biosynthesis; streptomycin biosynthesis.
CC   -!- SIMILARITY: Belongs to the amidinotransferase family. {ECO:0000305}.
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DR   EMBL; X78975; CAA55577.1; -; Genomic_DNA.
DR   EMBL; AJ006985; CAA07390.1; -; Genomic_DNA.
DR   PIR; S44235; S44235.
DR   RefSeq; WP_043497543.1; NZ_CP009438.1.
DR   AlphaFoldDB; Q54264; -.
DR   SMR; Q54264; -.
DR   STRING; 1907.SGLAU_01210; -.
DR   eggNOG; COG1834; Bacteria.
DR   OrthoDB; 592329at2; -.
DR   BRENDA; 2.1.4.2; 6023.
DR   UniPathway; UPA00066; -.
DR   GO; GO:0015069; F:scyllo-inosamine-4-phosphate amidinotransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019872; P:streptomycin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR033195; AmidinoTrfase.
DR   PANTHER; PTHR10488; PTHR10488; 1.
PE   3: Inferred from homology;
KW   Antibiotic biosynthesis; Streptomycin biosynthesis; Transferase.
FT   CHAIN           1..319
FT                   /note="Putative inosamine-phosphate amidinotransferase 2"
FT                   /id="PRO_0000215478"
FT   REGION          50..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            303
FT                   /note="Corresponds to active site cysteine in strB1"
SQ   SEQUENCE   319 AA;  34614 MW;  C8310B418FDEC02C CRC64;
     MSLAGVYTEW DPLEEIVVGT AVGSENRMVR ETEDELDGLC EELRGLGVTV RRLPPQDPAS
     PPAPPDRGAD TALAYRPRDG LLTVGETVIQ TPAVPGLPSL QSPACRMLLM EYFTSGSRWI
     SAPPPVLTDV MYDPTAPAGE RLRELEPVFD ADTVLRIGTD LLYLVSDSGN ALGARWLQAA
     LGERYTVHPC RGPHGSPHGD FAVVPLGPGL ILVNPERVDA EHIPPFLRTW KRIVCPELVD
     PGPPDGAVHS SGWGGSNILV VRPGLVIVDR RQADLMRVLE NNGIDVLPLQ LTHARALGSG
     FHRVTVDVRR TGTLESYRF