STRBP_HUMAN
ID STRBP_HUMAN Reviewed; 672 AA.
AC Q96SI9; Q32NB9; Q9BUE1; Q9BXG4; Q9H0B4; Q9H7V1; Q9NUK4;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 178.
DE RecName: Full=Spermatid perinuclear RNA-binding protein;
GN Name=STRBP; Synonyms=SPNR;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RA Sha J.H., Zhou Z.M., Li J.M.;
RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta, and Retinoblastoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Leiomyosarcoma, Retinoblastoma, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [10]
RP STRUCTURE BY NMR OF 378-461.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of DSRM domain in spermatid perinuclear RNA-binding
RT protein.";
RL Submitted (OCT-2006) to the PDB data bank.
RN [11]
RP VARIANT [LARGE SCALE ANALYSIS] ARG-280.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Involved in spermatogenesis and sperm function. Plays a role
CC in regulation of cell growth. Binds to double-stranded DNA and RNA.
CC Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds
CC also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA
CC PRM1 3'-UTR and adenovirus VA RNA (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with EIF2AK2. Associates with microtubules; it is
CC unsure whether such interaction is direct or indirect. {ECO:0000250}.
CC -!- INTERACTION:
CC Q96SI9; P78563-4: ADARB1; NbExp=3; IntAct=EBI-740355, EBI-12002366;
CC Q96SI9; Q13555-5: CAMK2G; NbExp=3; IntAct=EBI-740355, EBI-12020154;
CC Q96SI9; O75553: DAB1; NbExp=3; IntAct=EBI-740355, EBI-7875264;
CC Q96SI9; Q9UGU5: HMGXB4; NbExp=3; IntAct=EBI-740355, EBI-7261162;
CC Q96SI9; O75569: PRKRA; NbExp=3; IntAct=EBI-740355, EBI-713955;
CC Q96SI9; Q9NWB1-5: RBFOX1; NbExp=3; IntAct=EBI-740355, EBI-12123390;
CC Q96SI9; Q93062: RBPMS; NbExp=4; IntAct=EBI-740355, EBI-740322;
CC Q96SI9; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-740355, EBI-740343;
CC Q96SI9; Q6ZRY4: RBPMS2; NbExp=3; IntAct=EBI-740355, EBI-11987469;
CC Q96SI9; O95793: STAU1; NbExp=3; IntAct=EBI-740355, EBI-358174;
CC Q96SI9; Q15633: TARBP2; NbExp=3; IntAct=EBI-740355, EBI-978581;
CC Q96SI9; Q9NVV9: THAP1; NbExp=7; IntAct=EBI-740355, EBI-741515;
CC Q96SI9; Q9H898-2: ZMAT4; NbExp=3; IntAct=EBI-740355, EBI-11529334;
CC Q96SI9; Q9UL40: ZNF346; NbExp=3; IntAct=EBI-740355, EBI-2462313;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Microtubule-
CC associated that localizes to the manchette in developing spermatids.
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96SI9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96SI9-2; Sequence=VSP_022937;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI08732.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=BAA92120.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB14873.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF333337; AAK20832.1; -; mRNA.
DR EMBL; AL136866; CAB66800.1; -; mRNA.
DR EMBL; AK002169; BAA92120.1; ALT_INIT; mRNA.
DR EMBL; AK024285; BAB14873.1; ALT_INIT; mRNA.
DR EMBL; AK027890; BAB55434.1; -; mRNA.
DR EMBL; AL365338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC002693; AAH02693.2; -; mRNA.
DR EMBL; BC017732; AAH17732.1; -; mRNA.
DR EMBL; BC108731; AAI08732.1; ALT_SEQ; mRNA.
DR CCDS; CCDS55337.1; -. [Q96SI9-2]
DR CCDS; CCDS6851.1; -. [Q96SI9-1]
DR RefSeq; NP_001164608.1; NM_001171137.1. [Q96SI9-2]
DR RefSeq; NP_060857.2; NM_018387.4. [Q96SI9-1]
DR RefSeq; XP_016870383.1; XM_017014894.1.
DR RefSeq; XP_016870384.1; XM_017014895.1.
DR RefSeq; XP_016870385.1; XM_017014896.1.
DR PDB; 2DMY; NMR; -; A=378-461.
DR PDBsum; 2DMY; -.
DR AlphaFoldDB; Q96SI9; -.
DR SMR; Q96SI9; -.
DR BioGRID; 120623; 249.
DR IntAct; Q96SI9; 72.
DR MINT; Q96SI9; -.
DR STRING; 9606.ENSP00000415968; -.
DR GlyGen; Q96SI9; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96SI9; -.
DR MetOSite; Q96SI9; -.
DR PhosphoSitePlus; Q96SI9; -.
DR SwissPalm; Q96SI9; -.
DR BioMuta; STRBP; -.
DR DMDM; 74752134; -.
DR EPD; Q96SI9; -.
DR jPOST; Q96SI9; -.
DR MassIVE; Q96SI9; -.
DR MaxQB; Q96SI9; -.
DR PaxDb; Q96SI9; -.
DR PeptideAtlas; Q96SI9; -.
DR PRIDE; Q96SI9; -.
DR ProteomicsDB; 78115; -. [Q96SI9-1]
DR ProteomicsDB; 78116; -. [Q96SI9-2]
DR Antibodypedia; 16209; 82 antibodies from 21 providers.
DR DNASU; 55342; -.
DR Ensembl; ENST00000348403.10; ENSP00000321347.7; ENSG00000165209.19. [Q96SI9-1]
DR Ensembl; ENST00000360998.3; ENSP00000354271.3; ENSG00000165209.19. [Q96SI9-2]
DR Ensembl; ENST00000447404.6; ENSP00000415968.2; ENSG00000165209.19. [Q96SI9-1]
DR GeneID; 55342; -.
DR KEGG; hsa:55342; -.
DR MANE-Select; ENST00000348403.10; ENSP00000321347.7; NM_018387.5; NP_060857.2.
DR UCSC; uc004bnu.4; human. [Q96SI9-1]
DR CTD; 55342; -.
DR DisGeNET; 55342; -.
DR GeneCards; STRBP; -.
DR HGNC; HGNC:16462; STRBP.
DR HPA; ENSG00000165209; Low tissue specificity.
DR MIM; 611138; gene.
DR neXtProt; NX_Q96SI9; -.
DR OpenTargets; ENSG00000165209; -.
DR PharmGKB; PA38145; -.
DR VEuPathDB; HostDB:ENSG00000165209; -.
DR eggNOG; KOG3792; Eukaryota.
DR GeneTree; ENSGT00940000154687; -.
DR HOGENOM; CLU_015490_1_0_1; -.
DR InParanoid; Q96SI9; -.
DR OMA; SGDVHNQ; -.
DR PhylomeDB; Q96SI9; -.
DR TreeFam; TF320194; -.
DR PathwayCommons; Q96SI9; -.
DR SignaLink; Q96SI9; -.
DR BioGRID-ORCS; 55342; 11 hits in 1081 CRISPR screens.
DR ChiTaRS; STRBP; human.
DR EvolutionaryTrace; Q96SI9; -.
DR GeneWiki; STRBP; -.
DR GenomeRNAi; 55342; -.
DR Pharos; Q96SI9; Tbio.
DR PRO; PR:Q96SI9; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q96SI9; protein.
DR Bgee; ENSG00000165209; Expressed in secondary oocyte and 183 other tissues.
DR ExpressionAtlas; Q96SI9; baseline and differential.
DR Genevisible; Q96SI9; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0002177; C:manchette; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IDA:LIFEdb.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0003727; F:single-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0007638; P:mechanosensory behavior; IEA:Ensembl.
DR GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR CDD; cd19909; DSRM_STRBP_rpt1; 1.
DR Gene3D; 3.30.460.10; -; 1.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR006561; DZF_dom.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR030446; STRBP.
DR InterPro; IPR044472; STRBP_DSRM_1.
DR PANTHER; PTHR45762:SF1; PTHR45762:SF1; 3.
DR Pfam; PF00035; dsrm; 2.
DR Pfam; PF07528; DZF; 1.
DR SMART; SM00358; DSRM; 2.
DR SMART; SM00572; DZF; 1.
DR PROSITE; PS50137; DS_RBD; 2.
DR PROSITE; PS51703; DZF; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cytoplasm; Developmental protein;
KW Differentiation; DNA-binding; Methylation; Reference proteome; Repeat;
KW RNA-binding; Spermatogenesis.
FT CHAIN 1..672
FT /note="Spermatid perinuclear RNA-binding protein"
FT /id="PRO_0000274917"
FT DOMAIN 5..363
FT /note="DZF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01040"
FT DOMAIN 387..453
FT /note="DRBM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT DOMAIN 510..576
FT /note="DRBM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT REGION 52..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..499
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 612
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q91WM1"
FT MOD_RES 617
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q91WM1"
FT VAR_SEQ 1..14
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11230166"
FT /id="VSP_022937"
FT VARIANT 280
FT /note="G -> R (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035662"
FT CONFLICT 173..175
FT /note="LEK -> IGRR (in Ref. 1; AAK20832)"
FT /evidence="ECO:0000305"
FT CONFLICT 196
FT /note="L -> P (in Ref. 3; BAA92120)"
FT /evidence="ECO:0000305"
FT STRAND 385..387
FT /evidence="ECO:0007829|PDB:2DMY"
FT HELIX 390..398
FT /evidence="ECO:0007829|PDB:2DMY"
FT STRAND 405..411
FT /evidence="ECO:0007829|PDB:2DMY"
FT STRAND 413..415
FT /evidence="ECO:0007829|PDB:2DMY"
FT STRAND 417..424
FT /evidence="ECO:0007829|PDB:2DMY"
FT STRAND 427..435
FT /evidence="ECO:0007829|PDB:2DMY"
FT HELIX 436..451
FT /evidence="ECO:0007829|PDB:2DMY"
SQ SEQUENCE 672 AA; 73653 MW; 26465F4D3A429FBC CRC64;
MRSIRSFAND DRHVMVKHST IYPSPEELEA VQNMVSTVEC ALKHVSDWLD ETNKGTKTEG
ETEVKKDEAG ENYSKDQGGR TLCGVMRIGL VAKGLLIKDD MDLELVLMCK DKPTETLLNT
VKDNLPIQIQ KLTEEKYQVE QCVNEASIII RNTKEPTLTL KVILTSPLIR DELEKKDGEN
VSMKDPPDLL DRQKCLNALA SLRHAKWFQA RANGLKSCVI VLRILRDLCN RVPTWAPLKG
WPLELICEKS IGTCNRPLGA GEALRRVMEC LASGILLPGG PGLHDPCERD PTDALSYMTI
QQKEDITHSA QHALRLSAFG QIYKVLEMDP LPSSKPFQKY SWSVTDKEGA GSSALKRPFE
DGLGDDKDPN KKMKRNLRKI LDSKAIDLMN ALMRLNQIRP GLQYKLLSQS GPVHAPVFTM
SVDVDGTTYE ASGPSKKTAK LHVAVKVLQA MGYPTGFDAD IECMSSDEKS DNESKNETVS
SNSSNNTGNS TTETSSTLEV RTQGPILTAS GKNPVMELNE KRRGLKYELI SETGGSHDKR
FVMEVEVDGQ KFRGAGPNKK VAKASAALAA LEKLFSGPNA ANNKKKKIIP QAKGVVNTAV
SAAVQAVRGR GRGTLTRGAF VGATAAPGYI APGYGTPYGY STAAPAYGLP KRMVLLPVMK
FPTYPVPHYS FF
